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1.
Kageyama A, Yazawa K, Nishimura K, Mikami Y, 2004. Nocardia inohanensis sp. nov., Nocardia yamanashiensis sp. nov. and Nocardia niigatensis sp. nov., isolated from clinical specimens Int J Syst Evol Microbiol 54 : 563– 569.
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2.
Satterwhite TK, Wallace RJ, 1979. Primary cutaneous nocardiosis. JAMA 242 : 333– 336.
-
3.
Maraki S, Chochlidakis S, Nioti E, Tselentis Y, 2004. Primary lymphocutaneous nocardiosis in an immunocompetent patient. Ann Clin Microbiol Antimicrob 15 : 24.
-
4.
Tellez I, Franco-Paredes C, 2010. A woman with chronic subcutaneous swelling of the right foot associated with sinus tracts discharging yellow grains. PLoS Negl Trop Dis 4 : e772.
-
5.
CLSI, 2011. Susceptibility Testing of Mycobacteria, Nocardiae, and Other Aerobic Actinomycetes: Approved Standard—Second Edition. CLSI document M24-A2. Wayne, PA: Clinical and Laboratory Standards Institute.
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6.
Conville P, Witebsky FG, 2007. Analysis of multiple differing copies of the 16S rRNA gene in five clinical isolates and three type strains of Nocardia species and implications for species assignment. J Clin Microbiol 45 : 1146– 1151.
-
7.
Sorrel TC, Mitchell DH, Iredell JR, 2010. Nocardia species. Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. Seventh edition. Philadelphia, PA: Churchill Livingstone Elsevier, 3199– 3207.
-
8.
Adhikari L, Dey S, Pal R, 2010. Mycetoma due to Nocardia farcinica. J Glob Infect Dis 2 : 194– 195.
-
9.
Clark N, Braun D, Pasternak A, Chenoweth C, 1995. Primary cutaneous Nocardia otitidiscaviarum infection: case report and review. Clin Infect Dis 20 : 1266– 1270.
-
10.
Shimizu A, Ishikawa O, Nagai Y, Mikami Y, Nishimura K, 2001. Primary cutaneous nocardiosis due to Nocardia nova in a healthy woman. Br J Dermatol 145 : 154– 156.
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11.
Rodríguez-Nava V, Couble A, Molinard C, Sandoval H, Boiron P, Laurent F, 2004. Nocardia mexicana sp. nov., a new pathogen isolated from human mycetomas. J Clin Microbiol 42 : 4530– 4535.
-
12.
Steingrube VA, Wallace RJ Jr, Brown BA, Pang Y, Zeluff B, Steele LC, 1991. Acquired resistance of Nocardia brasiliensis to clavulanic acid related to a change in beta-lactamase following therapy with amoxicillin-clavulanic acid. Antimicrob Agents Chemother 35 : 524– 528.
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Mycetoma Caused by Nocardia yamanashiensis, Papua New Guinea
Oriol Mitjà
Oriol Mitjà
Lihir Medical Centre - International SOS, Lihir Island, Papua New Guinea; Sullivan Nicolaides Pathology, Brisbane, Australia; Barcelona Centre for International Health Research/Hospital Clínic/University of Barcelona, Spain
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Russell Hays
Russell Hays
Lihir Medical Centre - International SOS, Lihir Island, Papua New Guinea; Sullivan Nicolaides Pathology, Brisbane, Australia; Barcelona Centre for International Health Research/Hospital Clínic/University of Barcelona, Spain
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Christian Van Straten
Christian Van Straten
Lihir Medical Centre - International SOS, Lihir Island, Papua New Guinea; Sullivan Nicolaides Pathology, Brisbane, Australia; Barcelona Centre for International Health Research/Hospital Clínic/University of Barcelona, Spain
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Jenny Robson
Jenny Robson
Lihir Medical Centre - International SOS, Lihir Island, Papua New Guinea; Sullivan Nicolaides Pathology, Brisbane, Australia; Barcelona Centre for International Health Research/Hospital Clínic/University of Barcelona, Spain
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Murray Koka
Murray Koka
Lihir Medical Centre - International SOS, Lihir Island, Papua New Guinea; Sullivan Nicolaides Pathology, Brisbane, Australia; Barcelona Centre for International Health Research/Hospital Clínic/University of Barcelona, Spain
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Quique Bassat
Quique Bassat
Lihir Medical Centre - International SOS, Lihir Island, Papua New Guinea; Sullivan Nicolaides Pathology, Brisbane, Australia; Barcelona Centre for International Health Research/Hospital Clínic/University of Barcelona, Spain
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We report the first documented case of a mycetoma caused by Nocardia yamanashiensis after the initial description of this species. The 16S-rRNA gene sequence analysis was used to identify the novel species, which showed a similarity of 99.9% to the gene sequence of the type strain. The case showed both clinical non-response and reduced susceptibility in vitro to amoxicillin plus clavulanate, and it was treated successfully with trimethoprim-sulfamethoxazole and doxycycline. Given antibiotic resistance concerns, we suggest that antimicrobial susceptibility testing should be done for the majority of Nocardia species without well-established resistance patterns.
Author Notes
Financial support: This work was supported by InternationalSOS (Australasia) Pty Ltd., and Newcrest Mining (NML).
Disclosure: The patient provided signed consent authorizing publication of the case and images. Molecular identification was performed at the Mycobacterium Reference Laboratory, Queensland Health Scientific Services, Herston, Queensland, Australia.
Authors’ addresses: Oriol Mitjà, Russell Hays, Christian Van Straten, and Murray Koka, Department of Medicine, Lihir Medical Centre, Lihir Island, Papua New Guinea, E-mails: oriolmitja@hotmail.com, rhays@ozemail.com.au, cjvanstraten@hotmail.com, and MurrayJohn.koka@newcrest.com.au. Jenny Robson, Department of Microbiology, Sullivan Nicolaides Pathology, Brisbane, Australia, E-mail: jrobson@snp.com.au. Quique Bassat, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic/University of Barcelona, Barcelona, Spain, E-mail: quique.bassat@cresib.cat.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Kageyama A, Yazawa K, Nishimura K, Mikami Y, 2004. Nocardia inohanensis sp. nov., Nocardia yamanashiensis sp. nov. and Nocardia niigatensis sp. nov., isolated from clinical specimens Int J Syst Evol Microbiol 54 : 563– 569.
-
2.
Satterwhite TK, Wallace RJ, 1979. Primary cutaneous nocardiosis. JAMA 242 : 333– 336.
-
3.
Maraki S, Chochlidakis S, Nioti E, Tselentis Y, 2004. Primary lymphocutaneous nocardiosis in an immunocompetent patient. Ann Clin Microbiol Antimicrob 15 : 24.
-
4.
Tellez I, Franco-Paredes C, 2010. A woman with chronic subcutaneous swelling of the right foot associated with sinus tracts discharging yellow grains. PLoS Negl Trop Dis 4 : e772.
-
5.
CLSI, 2011. Susceptibility Testing of Mycobacteria, Nocardiae, and Other Aerobic Actinomycetes: Approved Standard—Second Edition. CLSI document M24-A2. Wayne, PA: Clinical and Laboratory Standards Institute.
-
6.
Conville P, Witebsky FG, 2007. Analysis of multiple differing copies of the 16S rRNA gene in five clinical isolates and three type strains of Nocardia species and implications for species assignment. J Clin Microbiol 45 : 1146– 1151.
-
7.
Sorrel TC, Mitchell DH, Iredell JR, 2010. Nocardia species. Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. Seventh edition. Philadelphia, PA: Churchill Livingstone Elsevier, 3199– 3207.
-
8.
Adhikari L, Dey S, Pal R, 2010. Mycetoma due to Nocardia farcinica. J Glob Infect Dis 2 : 194– 195.
-
9.
Clark N, Braun D, Pasternak A, Chenoweth C, 1995. Primary cutaneous Nocardia otitidiscaviarum infection: case report and review. Clin Infect Dis 20 : 1266– 1270.
-
10.
Shimizu A, Ishikawa O, Nagai Y, Mikami Y, Nishimura K, 2001. Primary cutaneous nocardiosis due to Nocardia nova in a healthy woman. Br J Dermatol 145 : 154– 156.
-
11.
Rodríguez-Nava V, Couble A, Molinard C, Sandoval H, Boiron P, Laurent F, 2004. Nocardia mexicana sp. nov., a new pathogen isolated from human mycetomas. J Clin Microbiol 42 : 4530– 4535.
-
12.
Steingrube VA, Wallace RJ Jr, Brown BA, Pang Y, Zeluff B, Steele LC, 1991. Acquired resistance of Nocardia brasiliensis to clavulanic acid related to a change in beta-lactamase following therapy with amoxicillin-clavulanic acid. Antimicrob Agents Chemother 35 : 524– 528.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 161 | 132 | 13 |
| Full Text Views | 305 | 9 | 0 |
| PDF Downloads | 102 | 7 | 0 |