ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Arribalzaga RA, 1955. New epidemic disease due to unidentified germ: nephrotoxic, leukopenic and enanthematous hyperthermia. Dia Med 27 :1204–1210.
-
2
Harrison LH, Halsey NA, McKee KT Jr, Peters CJ, Barrera Oro JG, Briggiler AM, Feuillade MR, Maiztegui JI, 1999. Clinical case definitions for Argentine hemorrhagic fever. Clin Infect Dis 28 :1091–1094.
-
3
Buchmeier MJ, de la Torre J-C, Peters CJ, 2007. 51. Arenaviridae: the viruses and their replication. Knipe DM, ed. Fields’ Virology. Philadelphia: Lippincott, Williams and Wilkins, 1635–1668.
-
4
Bowen MD, Peters CJ, Nichol ST, 1997. Phylogenetic analysis of the Arenaviridae: patterns of virus evolution and evidence for cospeciation between arenaviruses and their rodent hosts. Mol Phylogenet Evol 8 :301–316.
-
5
Enria DA, Barrera Oro JG, 2002. Junin virus vaccines. Curr Top Microbiol Immunol 263 :239–261.
-
6
Parodi AS, Greenway DJ, Rugiero HR, Frigerio M, De La Barrera JM, Mettler N, Garzon F, Boxaca M, Guerrero L, Nota N, 1958. Concerning the epidemic outbreak in Junin. Dia Med 30 :2300–2301.
-
7
Pirosky I, Zuccarini J, Molinelli EA, Di Pietro A, Barrera Oro JG, Martini P, Capello AR, 1959. Virosis Hemorrágica del Noroeste Bonaerense (Endemo Epidémica, Febril, Enantémática y Leucopenica). Buenos Aires: Instituto Nacional de Microbiologia, Minesterio de Asistencia Social y Salud Publica.
-
8
Salazar-Bravo J, Ruedas LA, Yates TL, 2002. Mammalian reservoirs of arenaviruses. Curr Top Microbiol Immunol 262 :25–63.
-
9
Parodi AS, Coto CE, Boxaca M, Lajmanovich S, Gonzalez S, 1966. Characteristics of Junin virus. Etiological agent of Argentine hemorrhagic fever. Arch Gesamte Virusforsch 19 :393–402.
-
10
Parodi AS, Rugiero HR, Greenway DJ, Mettler N, Boxaca M, 1961. Isolation of the Junin virus from rodents of non-epidemic areas. Prensa Med Argent 48 :2321–2322.
-
11
Parodi AS, Rugiero HR, Greenway DJ, Mettler N, Martinez A, Boxaca M, De La Barrera JM, 1959. Isolation of the Junin virus (epidemic hemorrhagic fever) from the mites of the epidemic area (Echinolaelaps echidninus, Barlese). Prensa Med Argent 46 :2242–2244.
-
12
Mills JN, Ellis BA, McKee KT Jr, Ksiazek TG, Oro JG, Maiztegui JI, Calderon GE, Peters CJ, Childs JE, 1991. Junin virus activity in rodents from endemic and nonendemic loci in central Argentina. Am J Trop Med Hyg 44 :589–597.
-
13
Enria DA, Briggiler AM, Levis S, Vallejos D, Maiztegui JI, Canonico PG, 1987. Tolerance and antiviral effect of ribavirin in patients with Argentine hemorrhagic fever. Antiviral Res 7 :353–359.
-
14
Enria DA, Maiztegui JI, 1994. Antiviral treatment of Argentine hemorrhagic fever. Antiviral Res 23 :23–31.
-
15
Enria DA, Briggiler AM, Fernandez NJ, Levis SC, Maiztegui JI, 1984. Importance of dose of neutralising antibodies in treatment of Argentine haemorrhagic fever with immune plasma. Lancet 2 :255–256.
-
16
Maiztegui JI, Fernandez NJ, de Damilano AJ, 1979. Efficacy of immune plasma in treatment of Argentine haemorrhagic fever and association between treatment and a late neurological syndrome. Lancet 2 :1216–1217.
-
17
Maiztegui JI, McKee KT Jr, Barrera Oro JG, Harrison LH, Gibbs PH, Feuillade MR, Enria DA, Briggiler AM, Levis SC, Ambrosio AM, Halsey NA, Peters CJ, 1998. Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group. J Infect Dis 177 :277–283.
-
18
Weissenbacher MC, de Guerrero LB, Boxaca MC, 1975. Experimental biology and pathogenesis of Junin virus infection in animals and man. Bull World Health Organ 52 :507–515.
-
19
Barrios HA, Rondinone SN, Blejer JL, Giovanniello OA, Nota NR, 1982. Development of specific immune response in mice infected with Junin virus. Acta Virol 26 :156–164.
-
20
Weissenbacher MC, Calello MA, Quintans CJ, Panisse H, Woyskowsky NM, Zannoli VH, 1983. Junin virus infection in genetically athymic mice. Intervirology 19 :1–5.
-
21
Campetella OE, Galassi NV, Sanjuan N, Barrios HA, 1988. Susceptible adult murine model for Junin virus. J Med Virol 26 :443–451.
-
22
Kenyon RH, Green DE, Maiztegui JI, Peters CJ, 1988. Viral strain dependent differences in experimental Argentine hemorrhagic fever. Intervirology 29 :133–143.
-
23
Remesar MC, Blejer JL, Lerman GD, Dejean C, Nejamkis MR, 1989. Protection against encephalitis in rats caused by a pathogenic strain of the Junin virus, using peripheral inoculation of an attenuated strain. Rev Argent Microbiol 21 :120–126.
-
24
Weissenbacher MC, Calello MA, Colillas OJ, Rondinone SN, Frigerio MJ, 1979. Argentine hemorrhagic fever: a primate model. Intervirology 11 :363–365.
-
25
McKee KT Jr, Mahlandt BG, Maiztegui JI, Eddy GA, Peters CJ, 1985. Experimental Argentine hemorrhagic fever in rhesus macaques: viral strain-dependent clinical response. J Infect Dis 152 :218–221.
-
26
McKee KT Jr, Green DE, Mahlandt BG, Bagley LR, Lyerly WH Jr, Peters CJ, Eddy GA, 1985. Infection of Cebus monkeys with Junin virus. Medicina (B Aires) 45 :144–152.
-
27
Avila MM, Samoilovich SR, Laguens RP, Merani MS, Weissenbacher MC, 1987. Protection of Junin virus-infected marmosets by passive administration of immune serum: association with late neurologic signs. J Med Virol 21 :67–74.
-
28
Carballal G, Oubina JR, Molinas FC, Nagle C, de la Vega MT, Videla C, Elsner B, 1987. Intracerebral infection of Cebus apella with the XJ-Clone 3 strain of Junin virus. J Med Virol 21 :257–268.
-
29
Kenyon RH, McKee KT Jr, Maiztegui JI, Green DE, Peters CJ, 1986. Heterogeneity of Junin virus strains. Med Microbiol Immunol (Berl) 175 :169–172.
-
30
Campetella OE, Barrios HA, Galassi NV, 1988. Junin virus-induced delayed-type hypersensitivity suppression in adult mice. J Med Virol 25 :227–235.
-
31
Kenyon RH, Peters CJ, 1986. Cytolysis of Junin infected target cells by immune guinea pig spleen cells. Microb Pathog 1 :453–464.
-
32
Calello MA, Rabinovich RD, Boxaca MC, Weissenbacher MC, 1986. Relationship between Junin virus infection of thymus and the establishment of persistence in rodents. Med Microbiol Immunol (Berl) 175 :109–112.
-
33
Weissenbacher MC, Calello MA, Merani S, Oubina JR, Laguens RP, Montoro L, Carballal G, 1986. Induction of Junin virus persistence in adult athymic mice. Intervirology 25 :210–215.
-
34
Kenyon RH, Green DE, Eddy GA, Peters CJ, 1986. Treatment of Junin virus-infected guinea pigs with immune serum: development of late neurological disease. J Med Virol 20 :207–218.
-
35
McKee KT Jr, Mahlandt BG, Maiztegui JI, Green DE, Peters CJ, 1987. Virus-specific factors in experimental Argentine hemorrhagic fever in rhesus macaques. J Med Virol 22 :99–111.
-
36
Kenyon RH, McKee KT Jr, Zack PM, Rippy MK, Vogel AP, York C, Meegan J, Crabbs C, Peters CJ, 1992. Aerosol infection of rhesus macaques with Junin virus. Intervirology 33 :23–31.
-
37
Elsner B, Boxaca MC, Weissenbacher M, De Guerrero LB, 1976. Experimental Junin virus infection of guinea pigs. I. Pathological anatomy. Medicina (B Aires) 36 :197–206.
-
38
Lopez N, Scolaro L, Rossi C, Jacamo R, Candurra N, Pujol C, Damonte EB, Franze-Fernandez MT, 2000. Homologous and heterologous glycoproteins induce protection against Junin virus challenge in guinea pigs. J Gen Virol 81 :1273–1281.
-
39
Peters CJ, Jahrling PB, Liu CT, Kenyon RH, McKee KT Jr, Barrera Oro JG, 1987. Experimental studies of arenaviral hemorrhagic fevers. Curr Top Microbiol Immunol 134 :5–68.
-
40
Aronson JF, Herzog NK, Jerrells TR, 1994. Pathological and virological features of arenavirus disease in guinea pigs. Comparison of two Pichinde virus strains. Am J Pathol 145 :228–235.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 238 | 205 | 20 |
| Full Text Views | 236 | 11 | 0 |
| PDF Downloads | 66 | 14 | 0 |
Pathogenesis of XJ and Romero Strains of Junin Virus in Two Strains of Guinea Pigs
Nadezhda E. Yun
Nadezhda E. Yun
Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Nathaniel S. Linde
Nathaniel S. Linde
Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Natallia Dziuba
Natallia Dziuba
Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Michele A. Zacks
Michele A. Zacks
Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Jeanon N. Smith
Jeanon N. Smith
Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Jennifer K. Smith
Jennifer K. Smith
Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Judy F. Aronson
Judy F. Aronson
Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Olga V. Chumakova
Olga V. Chumakova
Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Heather M. Lander
Heather M. Lander
Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Clarence J. Peters
Clarence J. Peters
Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Slobodan Paessler
Slobodan Paessler
Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Argentine hemorrhagic fever (AHF), a systemic infectious disease caused by infection with Junin virus, affects several organs, and patients can show hematologic, cardiovascular, renal, or neurologic symptoms. We compared the virulence of two Junin virus strains in inbred and outbred guinea pigs with the aim of characterizing this animal model better for future vaccine/antiviral efficacy studies. Our data indicate that this passage of the XJ strain is attenuated in guinea pigs. In contrast, the Romero strain is highly virulent in Strain 13 as well as in Hartley guinea pigs, resulting in systemic infection, thrombocytopenia, elevated apartate aminotransferase levels, and ultimately, uniformly lethal disease. We detected viral antigen in formalin-fixed, paraffin-embedded tissues. Thus, both guinea pig strains are useful animal models for lethal Junin virus (Romero strain) infection and potentially can be used for preclinical trials in vaccine or antiviral drug development.
Author Notes
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-
1
Arribalzaga RA, 1955. New epidemic disease due to unidentified germ: nephrotoxic, leukopenic and enanthematous hyperthermia. Dia Med 27 :1204–1210.
-
2
Harrison LH, Halsey NA, McKee KT Jr, Peters CJ, Barrera Oro JG, Briggiler AM, Feuillade MR, Maiztegui JI, 1999. Clinical case definitions for Argentine hemorrhagic fever. Clin Infect Dis 28 :1091–1094.
-
3
Buchmeier MJ, de la Torre J-C, Peters CJ, 2007. 51. Arenaviridae: the viruses and their replication. Knipe DM, ed. Fields’ Virology. Philadelphia: Lippincott, Williams and Wilkins, 1635–1668.
-
4
Bowen MD, Peters CJ, Nichol ST, 1997. Phylogenetic analysis of the Arenaviridae: patterns of virus evolution and evidence for cospeciation between arenaviruses and their rodent hosts. Mol Phylogenet Evol 8 :301–316.
-
5
Enria DA, Barrera Oro JG, 2002. Junin virus vaccines. Curr Top Microbiol Immunol 263 :239–261.
-
6
Parodi AS, Greenway DJ, Rugiero HR, Frigerio M, De La Barrera JM, Mettler N, Garzon F, Boxaca M, Guerrero L, Nota N, 1958. Concerning the epidemic outbreak in Junin. Dia Med 30 :2300–2301.
-
7
Pirosky I, Zuccarini J, Molinelli EA, Di Pietro A, Barrera Oro JG, Martini P, Capello AR, 1959. Virosis Hemorrágica del Noroeste Bonaerense (Endemo Epidémica, Febril, Enantémática y Leucopenica). Buenos Aires: Instituto Nacional de Microbiologia, Minesterio de Asistencia Social y Salud Publica.
-
8
Salazar-Bravo J, Ruedas LA, Yates TL, 2002. Mammalian reservoirs of arenaviruses. Curr Top Microbiol Immunol 262 :25–63.
-
9
Parodi AS, Coto CE, Boxaca M, Lajmanovich S, Gonzalez S, 1966. Characteristics of Junin virus. Etiological agent of Argentine hemorrhagic fever. Arch Gesamte Virusforsch 19 :393–402.
-
10
Parodi AS, Rugiero HR, Greenway DJ, Mettler N, Boxaca M, 1961. Isolation of the Junin virus from rodents of non-epidemic areas. Prensa Med Argent 48 :2321–2322.
-
11
Parodi AS, Rugiero HR, Greenway DJ, Mettler N, Martinez A, Boxaca M, De La Barrera JM, 1959. Isolation of the Junin virus (epidemic hemorrhagic fever) from the mites of the epidemic area (Echinolaelaps echidninus, Barlese). Prensa Med Argent 46 :2242–2244.
-
12
Mills JN, Ellis BA, McKee KT Jr, Ksiazek TG, Oro JG, Maiztegui JI, Calderon GE, Peters CJ, Childs JE, 1991. Junin virus activity in rodents from endemic and nonendemic loci in central Argentina. Am J Trop Med Hyg 44 :589–597.
-
13
Enria DA, Briggiler AM, Levis S, Vallejos D, Maiztegui JI, Canonico PG, 1987. Tolerance and antiviral effect of ribavirin in patients with Argentine hemorrhagic fever. Antiviral Res 7 :353–359.
-
14
Enria DA, Maiztegui JI, 1994. Antiviral treatment of Argentine hemorrhagic fever. Antiviral Res 23 :23–31.
-
15
Enria DA, Briggiler AM, Fernandez NJ, Levis SC, Maiztegui JI, 1984. Importance of dose of neutralising antibodies in treatment of Argentine haemorrhagic fever with immune plasma. Lancet 2 :255–256.
-
16
Maiztegui JI, Fernandez NJ, de Damilano AJ, 1979. Efficacy of immune plasma in treatment of Argentine haemorrhagic fever and association between treatment and a late neurological syndrome. Lancet 2 :1216–1217.
-
17
Maiztegui JI, McKee KT Jr, Barrera Oro JG, Harrison LH, Gibbs PH, Feuillade MR, Enria DA, Briggiler AM, Levis SC, Ambrosio AM, Halsey NA, Peters CJ, 1998. Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group. J Infect Dis 177 :277–283.
-
18
Weissenbacher MC, de Guerrero LB, Boxaca MC, 1975. Experimental biology and pathogenesis of Junin virus infection in animals and man. Bull World Health Organ 52 :507–515.
-
19
Barrios HA, Rondinone SN, Blejer JL, Giovanniello OA, Nota NR, 1982. Development of specific immune response in mice infected with Junin virus. Acta Virol 26 :156–164.
-
20
Weissenbacher MC, Calello MA, Quintans CJ, Panisse H, Woyskowsky NM, Zannoli VH, 1983. Junin virus infection in genetically athymic mice. Intervirology 19 :1–5.
-
21
Campetella OE, Galassi NV, Sanjuan N, Barrios HA, 1988. Susceptible adult murine model for Junin virus. J Med Virol 26 :443–451.
-
22
Kenyon RH, Green DE, Maiztegui JI, Peters CJ, 1988. Viral strain dependent differences in experimental Argentine hemorrhagic fever. Intervirology 29 :133–143.
-
23
Remesar MC, Blejer JL, Lerman GD, Dejean C, Nejamkis MR, 1989. Protection against encephalitis in rats caused by a pathogenic strain of the Junin virus, using peripheral inoculation of an attenuated strain. Rev Argent Microbiol 21 :120–126.
-
24
Weissenbacher MC, Calello MA, Colillas OJ, Rondinone SN, Frigerio MJ, 1979. Argentine hemorrhagic fever: a primate model. Intervirology 11 :363–365.
-
25
McKee KT Jr, Mahlandt BG, Maiztegui JI, Eddy GA, Peters CJ, 1985. Experimental Argentine hemorrhagic fever in rhesus macaques: viral strain-dependent clinical response. J Infect Dis 152 :218–221.
-
26
McKee KT Jr, Green DE, Mahlandt BG, Bagley LR, Lyerly WH Jr, Peters CJ, Eddy GA, 1985. Infection of Cebus monkeys with Junin virus. Medicina (B Aires) 45 :144–152.
-
27
Avila MM, Samoilovich SR, Laguens RP, Merani MS, Weissenbacher MC, 1987. Protection of Junin virus-infected marmosets by passive administration of immune serum: association with late neurologic signs. J Med Virol 21 :67–74.
-
28
Carballal G, Oubina JR, Molinas FC, Nagle C, de la Vega MT, Videla C, Elsner B, 1987. Intracerebral infection of Cebus apella with the XJ-Clone 3 strain of Junin virus. J Med Virol 21 :257–268.
-
29
Kenyon RH, McKee KT Jr, Maiztegui JI, Green DE, Peters CJ, 1986. Heterogeneity of Junin virus strains. Med Microbiol Immunol (Berl) 175 :169–172.
-
30
Campetella OE, Barrios HA, Galassi NV, 1988. Junin virus-induced delayed-type hypersensitivity suppression in adult mice. J Med Virol 25 :227–235.
-
31
Kenyon RH, Peters CJ, 1986. Cytolysis of Junin infected target cells by immune guinea pig spleen cells. Microb Pathog 1 :453–464.
-
32
Calello MA, Rabinovich RD, Boxaca MC, Weissenbacher MC, 1986. Relationship between Junin virus infection of thymus and the establishment of persistence in rodents. Med Microbiol Immunol (Berl) 175 :109–112.
-
33
Weissenbacher MC, Calello MA, Merani S, Oubina JR, Laguens RP, Montoro L, Carballal G, 1986. Induction of Junin virus persistence in adult athymic mice. Intervirology 25 :210–215.
-
34
Kenyon RH, Green DE, Eddy GA, Peters CJ, 1986. Treatment of Junin virus-infected guinea pigs with immune serum: development of late neurological disease. J Med Virol 20 :207–218.
-
35
McKee KT Jr, Mahlandt BG, Maiztegui JI, Green DE, Peters CJ, 1987. Virus-specific factors in experimental Argentine hemorrhagic fever in rhesus macaques. J Med Virol 22 :99–111.
-
36
Kenyon RH, McKee KT Jr, Zack PM, Rippy MK, Vogel AP, York C, Meegan J, Crabbs C, Peters CJ, 1992. Aerosol infection of rhesus macaques with Junin virus. Intervirology 33 :23–31.
-
37
Elsner B, Boxaca MC, Weissenbacher M, De Guerrero LB, 1976. Experimental Junin virus infection of guinea pigs. I. Pathological anatomy. Medicina (B Aires) 36 :197–206.
-
38
Lopez N, Scolaro L, Rossi C, Jacamo R, Candurra N, Pujol C, Damonte EB, Franze-Fernandez MT, 2000. Homologous and heterologous glycoproteins induce protection against Junin virus challenge in guinea pigs. J Gen Virol 81 :1273–1281.
-
39
Peters CJ, Jahrling PB, Liu CT, Kenyon RH, McKee KT Jr, Barrera Oro JG, 1987. Experimental studies of arenaviral hemorrhagic fevers. Curr Top Microbiol Immunol 134 :5–68.
-
40
Aronson JF, Herzog NK, Jerrells TR, 1994. Pathological and virological features of arenavirus disease in guinea pigs. Comparison of two Pichinde virus strains. Am J Pathol 145 :228–235.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 238 | 205 | 20 |
| Full Text Views | 236 | 11 | 0 |
| PDF Downloads | 66 | 14 | 0 |