ProCite
RefWorks
Reference Manager
BibTeX
Zotero
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-
1
Centers for Disease Control and Prevention, 2007. Lyme disease—United States, 2003–2005. Morbid Mortal Weekly Rep 56 :573–576.
-
2
Piesman J, Mather TN, Dammin GJ, Telford III Sr, Lastavica CC, Spielman A, 1987. Seasonal variation of transmission risk of Lyme disease and human babesiosis. Am J Epidemiol 126 :1187–1189.
-
3
Stafford KC III, Massung RF, Magnarelli LA, Ijdo JW, Anderson JF, 1999. Infection with agents of human granulocytic ehrlichiosis, Lyme disease, and babesiosis in wild white-footed mice (Peromyscus leucopus) in Connecticut. J Clin Microbiol 37 :2887–2892.
-
4
Slajchert T, Kitron UD, Jones CJ, Mannelli A, 1997. Role of the eastern chipmunk (Tamia striatus) in the epizootiology of Lyme borreliosis in northwestern Illinois, USA. J Wildl Dis 33 :40–46.
-
5
Brisson D, Dykhuizen DE, Ostfeld RS, 2008. Conspicuous impacts of inconspicuous hosts on the Lyme disease epidemic. Proc Biol Sci 275 :227–235.
-
6
Hayes EB, Piesman J, 2003. How can we prevent Lyme disease? N Engl J Med 348 :2424–2430.
-
7
Schulze TL, Jordan RA, Vasvary LM, Chomsky MS, Shaw DC, Meddis MA, Taylor RC, Piesman J, 1994. Suppression of Ixodes scapularis (Acari Ixodidae) nymphs in a large residential community. J Med Entomol 31 :206–211.
-
8
Dolan MC, Schneider BS, Denatale C, Hamon N, Cole C, Zeidner NS, Stafford KC III, Maupin GO, 2004. Control of immature Ixodes scapularis on rodent reservoirs of Borrelia burgdorferi in a residential community of southeastern Connecticut. J Med Entomol 41 :1043–1054.
-
9
Schulze TL, Jordan RA, Schulze CJ, Healy SP, Jahn MB, Piesman J, 2007. Integrated use of 4-poster passive topical treatment devices for deer, targeted acaricide applications, and Maxforce TMS bait boxes to rapidly suppress populations of Ixodes scapularis (Acari: Ixodidae) in a residential landscape. J Med Entomol 44 :830–839.
-
10
Monsel G, Canestri A, Caumes E, 2007. Antibiotherapy for early localized Lyme disease. Med Mal Infect 37 :463–472.
-
11
Nadelman RB, Nowakowski J, Fish D, Falco RC, Freeman K, McKenna D, Welch P, Marcus R, Aguero-Rosenfeld ME, Dennis DT, Wormser GP, 2001. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N Engl J Med 345 :79–84.
-
12
Zeidner NS, Brandt KS, Dadey E, Dolan MC, Happ C, Piesman J, 2004. Sustained-release formulation of doxycycline hyclate for prophylaxis of tick bite infection in a murine model of Lyme borreliosis. Antimicrob Agents Chemo 48 :2697–2699.
-
13
Massung RF, Zeidner NS, Dolan MC, Roelig D, Gabitzsch E, Troughton DR, Levin ML, 2005. Prophylactic use of sustained-release doxycycline blocks tick-transmitted infection by Ana-plasma phagocytophilum in a murine model. Ann N Y Acad Sci 1063 :436–438.
-
14
Poche RM, Genesis Laboratories, Inc., Wellington, CO. 1999. United States Patent No. 5,932,437. Control of Lyme disease spirochete.
-
15
Piesman J, 1993. Standard system for infecting ticks (Acari: Ixodidae) with the Lyme disease spirochete Borrelia burgdorferi. J Med Entomol 30 :199–203.
-
16
Schwartz I, Wormser GP, Schwartz JJ, Cooper D, Weissensee P, Gazumyan A, Zimmerman E, Goldberg NS, Bittker S, Campbell GL, Pavia CS, 1992. Diagnosis of early Lyme disease by polymerase chain reaction amplification and culture of skin biopsies from erythema migrans lesions. J Clin Microbiol 30 :3082–3088.
-
17
Sinsky RJ, Piesman J, 1989. Ear punch biopsy method for detection and isolation of Borrelia burgdorferi from rodents. J Clin Microbiol 27 :1723–1727.
-
18
Dolan MC, Maupin GO, Panella NA, Golde WT, Piesman J, 1997. Vector competence of Ixodes scapularis, Ixodes spinipalpis, and Dermacentor andersoni (Acari: Ixodidae) in transmitting Borrelia burgdorferi, the etiologic agent of Lyme disease. J Med Entomol 34 :128–135.
-
19
Mount GA, 1981. Amblyomma americanum: area control of overwintered nymphs and adults in Oklahoma with acaricides. J Econ Entomol 74 :24–26.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 347 | 319 | 27 |
| Full Text Views | 254 | 3 | 1 |
| PDF Downloads | 75 | 3 | 1 |
A Doxycycline Hyclate Rodent Bait Formulation for Prophylaxis and Treatment of Tick-transmitted Borrelia burgdorferi
Marc C. Dolan
Marc C. Dolan
Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado; Genesis Laboratories Incorporated, Wellington, Colorado
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Nordin S. Zeidner
Nordin S. Zeidner
Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado; Genesis Laboratories Incorporated, Wellington, Colorado
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Elizabeth Gabitzsch
Elizabeth Gabitzsch
Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado; Genesis Laboratories Incorporated, Wellington, Colorado
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Gabrielle Dietrich
Gabrielle Dietrich
Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado; Genesis Laboratories Incorporated, Wellington, Colorado
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Jeff N. Borchert
Jeff N. Borchert
Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado; Genesis Laboratories Incorporated, Wellington, Colorado
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Rich M. Poché
Rich M. Poché
Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado; Genesis Laboratories Incorporated, Wellington, Colorado
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Joseph Piesman
Joseph Piesman
Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado; Genesis Laboratories Incorporated, Wellington, Colorado
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The prophylactic and curative potential of doxycycline hyclate formulated in a rodent bait at concentrations of 250 and 500 mg/Kg was evaluated in a murine model of Lyme borreliosis. Both bait formulations prevented tick-transmitted Borrelia burgdorferi infection in 100% of C3H/HeJ mice (N = 16), as well as cured acute, established infection in mice (N = 8) exposed to bait for 14 days. Spirochete infection was cleared in 88.9% to 100% of infected nymphs feeding on mice fed 250 and 500 mg/Kg antibiotic bait formulations, respectively. These data provide evidence for exploring alternative techniques to prevent transmission of Lyme disease spirochetes.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
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-
1
Centers for Disease Control and Prevention, 2007. Lyme disease—United States, 2003–2005. Morbid Mortal Weekly Rep 56 :573–576.
-
2
Piesman J, Mather TN, Dammin GJ, Telford III Sr, Lastavica CC, Spielman A, 1987. Seasonal variation of transmission risk of Lyme disease and human babesiosis. Am J Epidemiol 126 :1187–1189.
-
3
Stafford KC III, Massung RF, Magnarelli LA, Ijdo JW, Anderson JF, 1999. Infection with agents of human granulocytic ehrlichiosis, Lyme disease, and babesiosis in wild white-footed mice (Peromyscus leucopus) in Connecticut. J Clin Microbiol 37 :2887–2892.
-
4
Slajchert T, Kitron UD, Jones CJ, Mannelli A, 1997. Role of the eastern chipmunk (Tamia striatus) in the epizootiology of Lyme borreliosis in northwestern Illinois, USA. J Wildl Dis 33 :40–46.
-
5
Brisson D, Dykhuizen DE, Ostfeld RS, 2008. Conspicuous impacts of inconspicuous hosts on the Lyme disease epidemic. Proc Biol Sci 275 :227–235.
-
6
Hayes EB, Piesman J, 2003. How can we prevent Lyme disease? N Engl J Med 348 :2424–2430.
-
7
Schulze TL, Jordan RA, Vasvary LM, Chomsky MS, Shaw DC, Meddis MA, Taylor RC, Piesman J, 1994. Suppression of Ixodes scapularis (Acari Ixodidae) nymphs in a large residential community. J Med Entomol 31 :206–211.
-
8
Dolan MC, Schneider BS, Denatale C, Hamon N, Cole C, Zeidner NS, Stafford KC III, Maupin GO, 2004. Control of immature Ixodes scapularis on rodent reservoirs of Borrelia burgdorferi in a residential community of southeastern Connecticut. J Med Entomol 41 :1043–1054.
-
9
Schulze TL, Jordan RA, Schulze CJ, Healy SP, Jahn MB, Piesman J, 2007. Integrated use of 4-poster passive topical treatment devices for deer, targeted acaricide applications, and Maxforce TMS bait boxes to rapidly suppress populations of Ixodes scapularis (Acari: Ixodidae) in a residential landscape. J Med Entomol 44 :830–839.
-
10
Monsel G, Canestri A, Caumes E, 2007. Antibiotherapy for early localized Lyme disease. Med Mal Infect 37 :463–472.
-
11
Nadelman RB, Nowakowski J, Fish D, Falco RC, Freeman K, McKenna D, Welch P, Marcus R, Aguero-Rosenfeld ME, Dennis DT, Wormser GP, 2001. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N Engl J Med 345 :79–84.
-
12
Zeidner NS, Brandt KS, Dadey E, Dolan MC, Happ C, Piesman J, 2004. Sustained-release formulation of doxycycline hyclate for prophylaxis of tick bite infection in a murine model of Lyme borreliosis. Antimicrob Agents Chemo 48 :2697–2699.
-
13
Massung RF, Zeidner NS, Dolan MC, Roelig D, Gabitzsch E, Troughton DR, Levin ML, 2005. Prophylactic use of sustained-release doxycycline blocks tick-transmitted infection by Ana-plasma phagocytophilum in a murine model. Ann N Y Acad Sci 1063 :436–438.
-
14
Poche RM, Genesis Laboratories, Inc., Wellington, CO. 1999. United States Patent No. 5,932,437. Control of Lyme disease spirochete.
-
15
Piesman J, 1993. Standard system for infecting ticks (Acari: Ixodidae) with the Lyme disease spirochete Borrelia burgdorferi. J Med Entomol 30 :199–203.
-
16
Schwartz I, Wormser GP, Schwartz JJ, Cooper D, Weissensee P, Gazumyan A, Zimmerman E, Goldberg NS, Bittker S, Campbell GL, Pavia CS, 1992. Diagnosis of early Lyme disease by polymerase chain reaction amplification and culture of skin biopsies from erythema migrans lesions. J Clin Microbiol 30 :3082–3088.
-
17
Sinsky RJ, Piesman J, 1989. Ear punch biopsy method for detection and isolation of Borrelia burgdorferi from rodents. J Clin Microbiol 27 :1723–1727.
-
18
Dolan MC, Maupin GO, Panella NA, Golde WT, Piesman J, 1997. Vector competence of Ixodes scapularis, Ixodes spinipalpis, and Dermacentor andersoni (Acari: Ixodidae) in transmitting Borrelia burgdorferi, the etiologic agent of Lyme disease. J Med Entomol 34 :128–135.
-
19
Mount GA, 1981. Amblyomma americanum: area control of overwintered nymphs and adults in Oklahoma with acaricides. J Econ Entomol 74 :24–26.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 347 | 319 | 27 |
| Full Text Views | 254 | 3 | 1 |
| PDF Downloads | 75 | 3 | 1 |