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-
1
Young JC, Hansen GR, Graves TK, Deasy MP, Humphreys JG, Frtiz CL, Gorham KL, Khan AS, Ksiazek TG, Metzger KB, Peters CJ, 2000. The incubation period of hantavirus pulmonary syndrome. Am J Trop Med Hyg 62 :714–717.
-
2
Botten J, Mirowsky K, Kusewitt D, Ye C, Gottlieb K, Prescott J, Hjelle B, 2003. Persistent Sin Nombre virus infection in the deer mouse (Peromyscus maniculatus) model: Sites of replication and strand specific expression. J Virol 77 :1540–1550.
-
3
Alberta Health and Wellness, 2005. Tests find high rates of hantavirus found in central Alberta deer mice. Government of Alberta. Available from www.gov.ab.ca.
-
4
Hedman K, Vaheri A, Brummer-Korvenkontio M, 1991. Rapid diagnosis of hantavirus disease with an IgG-avidity assay. Lancet 338 :1353–1356.
-
5
Kallio-Kokko H, Vapalahti O, Hedman K, Brummer-Korvenkontio M, Vaheri A, 1993. Puumala virus antibody and immunoglobulin G avidity assays based on a recombinant nucleocapsid antigen. J Clin Microbiol 31 :677–680.
-
6
Gavrilovskaya I, Apekina N, Okulova N, Demina V, Bernshtein A, Myasnikov Y, 1993. IgG avidity assay for estimation of the time after onset of hantavirus infection in colonized and wild bank voles. Arch Virol 132 :359–367.
-
7
Eisen HN, Siskind GW, 1964. Variations in affinities of antibodies during the immune response. Biochemistry 3 :996–1008.
-
8
Drebot MA, Gavrilovskaya I, Mackow ER, Chen Z, Lindsay R, Sanchez AJ, Nichol ST, Artsob H, 2001. Genetic and serotypic characterization of Sin Nombre-like viruses in Canadian Peromyscus maniculatus mice. Virus Res 75 :75–86.
-
9
Botten J, Mirowsky K, Kusewitt D, Bharadwaj M, Yee J, Ricci R, Feddersen RM, Hjelle B, 2000. Experimental infection model for Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus). Proc Natl Acad Sci U S A 97 :10578–10583.
-
10
Botten J, Ricci R, Hjelle B, 2001. Establishment of a deer mouse (Peromyscus maniculatus rufinus) breeding colony from wild-caught founders: comparison of reproductive performance of wild-caught and laboratory-reared pairs. Comp Med 51 :314–318.
-
11
Lindsay LR, Drebot MA, Weiss E, Artsob H, 2001. Hantavirus pulmonary syndrome in Manitoba. Can J Infect Dis 12 :169–173.
-
12
Safronetz D, Lindsay R, Dibernardo A, Hjelle B, Xiao R, Arstob H, Drebot MA, 2005. A preliminary study of the patterns of Sin Nombre viral infection and shedding in naturally infected deer mice (Peromyscus maniculatus). Vector Borne Zoonotic Dis 5 :127–132.
-
13
Calisher CH, Root JJ, Mills JN, Rowe JE, Reeder SA, Jentes ES, Wagoner K, Beaty BJ, 2005. Epizootiology of Sin Nombre and El Moro Canyon hantaviruses in southeastern Colorado, 1995– 2000. J Wildl Dis 41 :1–11.
-
14
Douglass RJ, Wilson T, Semmens WJ, Zanto SN, Bond CW, Van Horn RC, Mills JN, 2001. Longitudinal studies of Sin Nombre virus in deer mouse-dominated ecosystems of Montana. Am J Trop Med Hyg 65 :33–41.
-
15
Kuenzi AJ, Douglass RJ, Bond CW, Calisher CH, Mills JN, 2005. Long-term dynamics of Sin Nombre viral RNA and antibody in deer mice in Montana. J Wildl Dis 41 :473–481.
-
16
Mills JN, 2005. Regulation of rodent-borne viruses in their natural hosts: implications for human disease. Arch Virol Suppl 19 :45–57.
-
17
Hutchinson KL, Rollin PE, Peters CJ, 1998. Pathogenesis of a North American hantavirus, Black Creek Canal virus, in experimentally infected Sigmodon hispidus. Am J Trop Med Hyg 59 :58–65.
-
18
Netski D, Thran BH, St. Jeor S, 1999. Sin Nombre virus pathogenesis in Peromyscus maniculatus. J Virol 73 :585–591.
-
19
Borucki MK, Boone JD, Rowe JE, Bohlman MC, Kuhn EA, DeBaca R, St. Jeor S, 2000. Role of maternal antibody in natural infection of Peromyscus maniculatus with Sin Nombre virus. J Virol 74 :2426–2429.
-
20
Calisher CH, Sweeney W, Mills JN, Beaty BJ, 1999. Natural history of Sin Nombre virus in western Colorado. Emerg Infect Dis 5 :126–134.
-
21
Mills JN, Corneli A, Young JC, Garrison LE, Khan AS, Ksiazek TG, 2002. Hantavirus pulmonary syndrome–United States: updated recommendations for risk reduction. Centers for Disease Control and Prevention. MMWR Morb Mortal Wkly Rep 51 :1–12.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 188 | 168 | 6 |
| Full Text Views | 210 | 4 | 1 |
| PDF Downloads | 53 | 4 | 1 |
USE OF IgG AVIDITY TO INDIRECTLY MONITOR EPIZOOTIC TRANSMISSION OF SIN NOMBRE VIRUS IN DEER MICE (PEROMYSCUS MANICULATUS)
DAVID SAFRONETZ
DAVID SAFRONETZ
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Center for Infectious Diseases and Immunity, Departments of Pathology, Biology, and Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
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ROBBIN LINDSAY
ROBBIN LINDSAY
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Center for Infectious Diseases and Immunity, Departments of Pathology, Biology, and Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
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BRIAN HJELLE
BRIAN HJELLE
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Center for Infectious Diseases and Immunity, Departments of Pathology, Biology, and Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
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RAFAEL A. MEDINA
RAFAEL A. MEDINA
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Center for Infectious Diseases and Immunity, Departments of Pathology, Biology, and Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
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KATY MIROWSKY-GARCIA
KATY MIROWSKY-GARCIA
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Center for Infectious Diseases and Immunity, Departments of Pathology, Biology, and Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
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MICHAEL A. DREBOT
MICHAEL A. DREBOT
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Center for Infectious Diseases and Immunity, Departments of Pathology, Biology, and Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
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An IgG avidity assay was developed to differentiate deer mice that had recently acquired Sin Nombre virus (SNV) from those that were infected in the distant past. Using this procedure, low avidity antibodies were predominantly detected in experimentally infected deer mice (89.5%) within the first 30 days post-inoculation. The assay was then applied to sera from naturally infected deer mice collected during a field investigation associated with a cluster of hantavirus pulmonary syndrome cases. A higher proportion of seropositive mice collected during the outbreak had serum with low avidity antibodies (16.7%) when compared with mice trapped four months later (5.7%). Sin Nombre virus RNA was detectable in blood in a similar fraction of low- (45%) and high- (38.7%) avidity groups. Non-adult mice were more likely to contain low-avidity antibodies (44.4%) than were adults (9.6%). Our results indicate that the IgG avidity assay shows promise as a tool to better characterize epizootic intensity and to identify factors involved in SNV transmission.
Author Notes
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-
1
Young JC, Hansen GR, Graves TK, Deasy MP, Humphreys JG, Frtiz CL, Gorham KL, Khan AS, Ksiazek TG, Metzger KB, Peters CJ, 2000. The incubation period of hantavirus pulmonary syndrome. Am J Trop Med Hyg 62 :714–717.
-
2
Botten J, Mirowsky K, Kusewitt D, Ye C, Gottlieb K, Prescott J, Hjelle B, 2003. Persistent Sin Nombre virus infection in the deer mouse (Peromyscus maniculatus) model: Sites of replication and strand specific expression. J Virol 77 :1540–1550.
-
3
Alberta Health and Wellness, 2005. Tests find high rates of hantavirus found in central Alberta deer mice. Government of Alberta. Available from www.gov.ab.ca.
-
4
Hedman K, Vaheri A, Brummer-Korvenkontio M, 1991. Rapid diagnosis of hantavirus disease with an IgG-avidity assay. Lancet 338 :1353–1356.
-
5
Kallio-Kokko H, Vapalahti O, Hedman K, Brummer-Korvenkontio M, Vaheri A, 1993. Puumala virus antibody and immunoglobulin G avidity assays based on a recombinant nucleocapsid antigen. J Clin Microbiol 31 :677–680.
-
6
Gavrilovskaya I, Apekina N, Okulova N, Demina V, Bernshtein A, Myasnikov Y, 1993. IgG avidity assay for estimation of the time after onset of hantavirus infection in colonized and wild bank voles. Arch Virol 132 :359–367.
-
7
Eisen HN, Siskind GW, 1964. Variations in affinities of antibodies during the immune response. Biochemistry 3 :996–1008.
-
8
Drebot MA, Gavrilovskaya I, Mackow ER, Chen Z, Lindsay R, Sanchez AJ, Nichol ST, Artsob H, 2001. Genetic and serotypic characterization of Sin Nombre-like viruses in Canadian Peromyscus maniculatus mice. Virus Res 75 :75–86.
-
9
Botten J, Mirowsky K, Kusewitt D, Bharadwaj M, Yee J, Ricci R, Feddersen RM, Hjelle B, 2000. Experimental infection model for Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus). Proc Natl Acad Sci U S A 97 :10578–10583.
-
10
Botten J, Ricci R, Hjelle B, 2001. Establishment of a deer mouse (Peromyscus maniculatus rufinus) breeding colony from wild-caught founders: comparison of reproductive performance of wild-caught and laboratory-reared pairs. Comp Med 51 :314–318.
-
11
Lindsay LR, Drebot MA, Weiss E, Artsob H, 2001. Hantavirus pulmonary syndrome in Manitoba. Can J Infect Dis 12 :169–173.
-
12
Safronetz D, Lindsay R, Dibernardo A, Hjelle B, Xiao R, Arstob H, Drebot MA, 2005. A preliminary study of the patterns of Sin Nombre viral infection and shedding in naturally infected deer mice (Peromyscus maniculatus). Vector Borne Zoonotic Dis 5 :127–132.
-
13
Calisher CH, Root JJ, Mills JN, Rowe JE, Reeder SA, Jentes ES, Wagoner K, Beaty BJ, 2005. Epizootiology of Sin Nombre and El Moro Canyon hantaviruses in southeastern Colorado, 1995– 2000. J Wildl Dis 41 :1–11.
-
14
Douglass RJ, Wilson T, Semmens WJ, Zanto SN, Bond CW, Van Horn RC, Mills JN, 2001. Longitudinal studies of Sin Nombre virus in deer mouse-dominated ecosystems of Montana. Am J Trop Med Hyg 65 :33–41.
-
15
Kuenzi AJ, Douglass RJ, Bond CW, Calisher CH, Mills JN, 2005. Long-term dynamics of Sin Nombre viral RNA and antibody in deer mice in Montana. J Wildl Dis 41 :473–481.
-
16
Mills JN, 2005. Regulation of rodent-borne viruses in their natural hosts: implications for human disease. Arch Virol Suppl 19 :45–57.
-
17
Hutchinson KL, Rollin PE, Peters CJ, 1998. Pathogenesis of a North American hantavirus, Black Creek Canal virus, in experimentally infected Sigmodon hispidus. Am J Trop Med Hyg 59 :58–65.
-
18
Netski D, Thran BH, St. Jeor S, 1999. Sin Nombre virus pathogenesis in Peromyscus maniculatus. J Virol 73 :585–591.
-
19
Borucki MK, Boone JD, Rowe JE, Bohlman MC, Kuhn EA, DeBaca R, St. Jeor S, 2000. Role of maternal antibody in natural infection of Peromyscus maniculatus with Sin Nombre virus. J Virol 74 :2426–2429.
-
20
Calisher CH, Sweeney W, Mills JN, Beaty BJ, 1999. Natural history of Sin Nombre virus in western Colorado. Emerg Infect Dis 5 :126–134.
-
21
Mills JN, Corneli A, Young JC, Garrison LE, Khan AS, Ksiazek TG, 2002. Hantavirus pulmonary syndrome–United States: updated recommendations for risk reduction. Centers for Disease Control and Prevention. MMWR Morb Mortal Wkly Rep 51 :1–12.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 188 | 168 | 6 |
| Full Text Views | 210 | 4 | 1 |
| PDF Downloads | 53 | 4 | 1 |