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-
1
Becker K, Tilley L, Vennerstrom JL, Roberts D, Rogerson S, Ginsburg H, 2004. Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions. Int J Parasitol 34 :163–189.
-
2
Deharo E, Barkan D, Krugliak M, Golenser J, Ginsburg H, 2003. Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels. Biochem Pharmacol 66 :809–817.
-
3
Mukanganyama S, Widersten M, Naik YS, Mannervik B, Hasler JA, 2002. Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. Int J Cancer 97 :700–705.
-
4
Abdulhadi NH, 2003. Protection against severe clinical manifestations of Plasmodium falciparum malaria among sickle cell trait subjects is due to modification of the release of cytokines and/or cytoadherence of infected erythrocytes to the host vascular beds. Med Hypotheses 60 :912–914.
-
5
Ferreira, ID, Nogueira, F, Borges, ST, do Rosario VE, Cravo P, 2004. Is the expression of genes encoding enzymes of glutathione (GSH) metabolism involved in chloroquine resistance in Plasmodium chabaudi parasites? Mol Biochem Parasitol 136 :43–50
-
6
Schwarzer E, Turrini F, Giribaldi G, Cappadoro M, Arese P, 1993. Phagocytosis of P. falciparum malarial pigment hemozoin by human monocytes inactivates monocyte protein kinase C. Biochim Biophys Acta 1181 :51–54.
-
7
Schwarzer E, Arese P, 1996. Phagocytosis of malarial pigment hemozoin inhibits NADPH-oxidase activity in human monocyte-derived macrophages. Biochim Biophys Acta 1316 :169–175.
-
8
Taramelli D, Basilico N, Pagani E, Grande R, Monti D, Ghione M, Olliaro P, 1995. The heme moiety of malaria pigment (beta-hematin) mediates the inhibition of nitric oxide and tumor necrosis factor-alpha production by lipopolysaccharide-stimulated macrophages. Exp Parasitol 81 :501–511.
-
9
Strange RC, Lear JT, Fryer AA, 1998. Glutathione S-transferase polymorphisms: influence on susceptibility to cancer. Chem Biol Interact 111–112 :351–364.
-
10
Wikman H, Thiel S, Schmezer P, Drings P, Dienemann H, Kayser K, Schulz V, Spiegelhalder B, Bartsch H, Risch A, 1999. Genetic polymorphisms in GSTs and individual susceptibility to lung cancer. Lung Cancer 25 :S14–S15.
-
11
Ye Z, Song H, 2005. Glutathione s-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysis. Eur J Cancer 41 :980–989.
-
12
Hermsen CC, Konijnenberg Y, Mulder L, Loe C, van Deuren M, van der Meer JW, van Mierlo GJ, Eling WM, Hack CE, Sauerwein RW, 2003. Circulating concentrations of soluble granzyme A and B increase during natural and experimental Plasmodium falciparum infections. Clin Exp Immunol 132 :467–472.
-
13
Molyneux ME, Taylor TE, Wirima JJ, Borgstein A, 1989. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med 71 :441–459.
-
14
Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, Marsh V, Newton C, Winstanley P, Warn P, Peshu N, 1995. Indicators of life-threatening malaria in African children. N Engl J Med 332 :1399–1404.
-
15
Brockmoller J, Kerb R, Drakoulis N, Nitz M, Roots I, 1993. Genotype and phenotype of glutathione S-transferase class mu isoenzymes mu and psi in lung cancer patients and controls. Cancer Res 53 :1004–1011.
-
16
Pemble S, Schroeder KR, Spencer SR, Meyer DJ, Hallier E, Bolt HM, Ketterer B, Taylor JB, 1994. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J 300 :271–276.
-
17
van Lieshout EM, Roelofs HM, Dekker S, Mulder CJ, Wobbes T, Jansen JB, Peters WH, 1999. Polymorphic expression of the glutathione S-transferase P1 gene and its susceptibility to Barrett’s esophagus and esophageal carcinoma. Cancer Res 59 :586–589.
-
18
Watson MA, Stewart RK, Smith GB, Massey TE, Bell DA, 1998. Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution. Carcinogenesis 19 :275–280.
-
19
Platel DF, Mangou F, Tribouley-Duret J, 1999. Role of glutathione in the detoxification of ferriprotoporphyrin IX in chloroquine resistant Plasmodium berghei. Mol Biochem Parasitol 98 :215–223.
-
20
Mukanganyama S, Masimirembwa CM, Naik YS, Hasler JA, 1997. Phenotyping of the glutathione S-transferase M1 polymorphism in Zimbabweans and the effects of chloroquine on blood glutathione S-transferases M1 and A. Clin Chim Acta 265 :145–155.
-
21
Rossini A, Rapozo DC, Amorim LM, Macedo JM, Medina R, Neto JF, Gallo CV, Pinto LF, 2002. Frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms in a Brazilian population. Genet Mol Res 1 :233–240.
-
22
Tiemersma EW, Omer RE, Bunschoten A, van’t Veer P, Kok FJ, Idris MO, Kadaru AM, Fedail SS, Kampman E, 2001. Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma. Cancer Epidemiol Biomarkers Prev 10 :785–791.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 460 | 433 | 23 |
| Full Text Views | 210 | 5 | 1 |
| PDF Downloads | 42 | 4 | 1 |
SEVERE PLASMODIUM FALCIPARUM MALARIA IN CAMEROON: ASSOCIATED WITH THE GLUTATHIONE S-TRANSFERASE M1 NULL GENOTYPE
REGINALD A. KAVISHE
REGINALD A. KAVISHE
Departments of Pharmacology and Toxicology, Medical Microbiology, Gastroenterology, Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Kilimanjaro Christian Medical College of Tumaini University, Tanzania.
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JAN B. KOENDERINK
JAN B. KOENDERINK
Departments of Pharmacology and Toxicology, Medical Microbiology, Gastroenterology, Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Kilimanjaro Christian Medical College of Tumaini University, Tanzania.
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MATTHEW B.B. MCCALL
MATTHEW B.B. MCCALL
Departments of Pharmacology and Toxicology, Medical Microbiology, Gastroenterology, Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Kilimanjaro Christian Medical College of Tumaini University, Tanzania.
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WILBERT H.M. PETERS
WILBERT H.M. PETERS
Departments of Pharmacology and Toxicology, Medical Microbiology, Gastroenterology, Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Kilimanjaro Christian Medical College of Tumaini University, Tanzania.
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BERT MULDER
BERT MULDER
Departments of Pharmacology and Toxicology, Medical Microbiology, Gastroenterology, Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Kilimanjaro Christian Medical College of Tumaini University, Tanzania.
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CORNELUS C. HERMSEN
CORNELUS C. HERMSEN
Departments of Pharmacology and Toxicology, Medical Microbiology, Gastroenterology, Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Kilimanjaro Christian Medical College of Tumaini University, Tanzania.
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ROBERT W. SAUERWEIN
ROBERT W. SAUERWEIN
Departments of Pharmacology and Toxicology, Medical Microbiology, Gastroenterology, Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Kilimanjaro Christian Medical College of Tumaini University, Tanzania.
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FRANS G.M. RUSSEL
FRANS G.M. RUSSEL
Departments of Pharmacology and Toxicology, Medical Microbiology, Gastroenterology, Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Kilimanjaro Christian Medical College of Tumaini University, Tanzania.
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ANDRE J.A.M. VAN DER VEN
ANDRE J.A.M. VAN DER VEN
Departments of Pharmacology and Toxicology, Medical Microbiology, Gastroenterology, Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Kilimanjaro Christian Medical College of Tumaini University, Tanzania.
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Glutathione S-transferases (GST) are a family of enzymes involved in phase-II detoxification of endogenous and xenobiotic compounds. Polymorphisms in GST genes have been associated with susceptibility to different diseases. In this study we determined the frequencies of polymorphisms in GSTM1, GSTT1, and GSTP1 in DNA of 138 children from Cameroon, presenting with uncomplicated malaria (N = 19), malaria with minor complications (N = 81), or severe malaria (N = 38). Analyses of GSTM1 and GSTT1 were performed using PCR-multiplex procedure, while GSTP1 was done by PCR-RFLP. Subjects presenting with malaria with complications were found more often of the GSTM1-null genotype (58–64%) as compared with those with uncomplicated malaria (32%), a difference that was statistically significant. We conclude that the GSTM1-null genotype is associated with malaria with complications.
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-
1
Becker K, Tilley L, Vennerstrom JL, Roberts D, Rogerson S, Ginsburg H, 2004. Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions. Int J Parasitol 34 :163–189.
-
2
Deharo E, Barkan D, Krugliak M, Golenser J, Ginsburg H, 2003. Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels. Biochem Pharmacol 66 :809–817.
-
3
Mukanganyama S, Widersten M, Naik YS, Mannervik B, Hasler JA, 2002. Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. Int J Cancer 97 :700–705.
-
4
Abdulhadi NH, 2003. Protection against severe clinical manifestations of Plasmodium falciparum malaria among sickle cell trait subjects is due to modification of the release of cytokines and/or cytoadherence of infected erythrocytes to the host vascular beds. Med Hypotheses 60 :912–914.
-
5
Ferreira, ID, Nogueira, F, Borges, ST, do Rosario VE, Cravo P, 2004. Is the expression of genes encoding enzymes of glutathione (GSH) metabolism involved in chloroquine resistance in Plasmodium chabaudi parasites? Mol Biochem Parasitol 136 :43–50
-
6
Schwarzer E, Turrini F, Giribaldi G, Cappadoro M, Arese P, 1993. Phagocytosis of P. falciparum malarial pigment hemozoin by human monocytes inactivates monocyte protein kinase C. Biochim Biophys Acta 1181 :51–54.
-
7
Schwarzer E, Arese P, 1996. Phagocytosis of malarial pigment hemozoin inhibits NADPH-oxidase activity in human monocyte-derived macrophages. Biochim Biophys Acta 1316 :169–175.
-
8
Taramelli D, Basilico N, Pagani E, Grande R, Monti D, Ghione M, Olliaro P, 1995. The heme moiety of malaria pigment (beta-hematin) mediates the inhibition of nitric oxide and tumor necrosis factor-alpha production by lipopolysaccharide-stimulated macrophages. Exp Parasitol 81 :501–511.
-
9
Strange RC, Lear JT, Fryer AA, 1998. Glutathione S-transferase polymorphisms: influence on susceptibility to cancer. Chem Biol Interact 111–112 :351–364.
-
10
Wikman H, Thiel S, Schmezer P, Drings P, Dienemann H, Kayser K, Schulz V, Spiegelhalder B, Bartsch H, Risch A, 1999. Genetic polymorphisms in GSTs and individual susceptibility to lung cancer. Lung Cancer 25 :S14–S15.
-
11
Ye Z, Song H, 2005. Glutathione s-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysis. Eur J Cancer 41 :980–989.
-
12
Hermsen CC, Konijnenberg Y, Mulder L, Loe C, van Deuren M, van der Meer JW, van Mierlo GJ, Eling WM, Hack CE, Sauerwein RW, 2003. Circulating concentrations of soluble granzyme A and B increase during natural and experimental Plasmodium falciparum infections. Clin Exp Immunol 132 :467–472.
-
13
Molyneux ME, Taylor TE, Wirima JJ, Borgstein A, 1989. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med 71 :441–459.
-
14
Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, Marsh V, Newton C, Winstanley P, Warn P, Peshu N, 1995. Indicators of life-threatening malaria in African children. N Engl J Med 332 :1399–1404.
-
15
Brockmoller J, Kerb R, Drakoulis N, Nitz M, Roots I, 1993. Genotype and phenotype of glutathione S-transferase class mu isoenzymes mu and psi in lung cancer patients and controls. Cancer Res 53 :1004–1011.
-
16
Pemble S, Schroeder KR, Spencer SR, Meyer DJ, Hallier E, Bolt HM, Ketterer B, Taylor JB, 1994. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J 300 :271–276.
-
17
van Lieshout EM, Roelofs HM, Dekker S, Mulder CJ, Wobbes T, Jansen JB, Peters WH, 1999. Polymorphic expression of the glutathione S-transferase P1 gene and its susceptibility to Barrett’s esophagus and esophageal carcinoma. Cancer Res 59 :586–589.
-
18
Watson MA, Stewart RK, Smith GB, Massey TE, Bell DA, 1998. Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution. Carcinogenesis 19 :275–280.
-
19
Platel DF, Mangou F, Tribouley-Duret J, 1999. Role of glutathione in the detoxification of ferriprotoporphyrin IX in chloroquine resistant Plasmodium berghei. Mol Biochem Parasitol 98 :215–223.
-
20
Mukanganyama S, Masimirembwa CM, Naik YS, Hasler JA, 1997. Phenotyping of the glutathione S-transferase M1 polymorphism in Zimbabweans and the effects of chloroquine on blood glutathione S-transferases M1 and A. Clin Chim Acta 265 :145–155.
-
21
Rossini A, Rapozo DC, Amorim LM, Macedo JM, Medina R, Neto JF, Gallo CV, Pinto LF, 2002. Frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms in a Brazilian population. Genet Mol Res 1 :233–240.
-
22
Tiemersma EW, Omer RE, Bunschoten A, van’t Veer P, Kok FJ, Idris MO, Kadaru AM, Fedail SS, Kampman E, 2001. Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma. Cancer Epidemiol Biomarkers Prev 10 :785–791.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 460 | 433 | 23 |
| Full Text Views | 210 | 5 | 1 |
| PDF Downloads | 42 | 4 | 1 |