| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1132 | 707 | 55 |
| Full Text Views | 26 | 3 | 0 |
| PDF Downloads | 29 | 4 | 0 |
Comparative Efficacy of Clearing-Dose and Single High-Dose Ivermectin and Diethylcarbamazine against Wuchereria bancrofti Microfilaremia
David G. Addiss
David G. Addiss
Division of Parasitic Diseases, National Center for Infectious Diseases, and Division of Field Epidemiology, Epidemiology Program Office, Centers for Disease Control, Sainte Croix Hospital, Atlanta, Georgia, Haiti
Search for other papers by David G. Addiss in
Current site
Google Scholar
PubMed
Search for other papers by David G. Addiss in
Current site
Google Scholar
PubMed
Mark L. Eberhard
Mark L. Eberhard
Division of Parasitic Diseases, National Center for Infectious Diseases, and Division of Field Epidemiology, Epidemiology Program Office, Centers for Disease Control, Sainte Croix Hospital, Atlanta, Georgia, Haiti
Search for other papers by Mark L. Eberhard in
Current site
Google Scholar
PubMed
Search for other papers by Mark L. Eberhard in
Current site
Google Scholar
PubMed
Patrick J. Lammie
Patrick J. Lammie
Division of Parasitic Diseases, National Center for Infectious Diseases, and Division of Field Epidemiology, Epidemiology Program Office, Centers for Disease Control, Sainte Croix Hospital, Atlanta, Georgia, Haiti
Search for other papers by Patrick J. Lammie in
Current site
Google Scholar
PubMed
Search for other papers by Patrick J. Lammie in
Current site
Google Scholar
PubMed
Marise Bayard McNeeley
Marise Bayard McNeeley
Division of Parasitic Diseases, National Center for Infectious Diseases, and Division of Field Epidemiology, Epidemiology Program Office, Centers for Disease Control, Sainte Croix Hospital, Atlanta, Georgia, Haiti
Search for other papers by Marise Bayard McNeeley in
Current site
Google Scholar
PubMed
Search for other papers by Marise Bayard McNeeley in
Current site
Google Scholar
PubMed
Susan H. Lee
Susan H. Lee
Division of Parasitic Diseases, National Center for Infectious Diseases, and Division of Field Epidemiology, Epidemiology Program Office, Centers for Disease Control, Sainte Croix Hospital, Atlanta, Georgia, Haiti
Search for other papers by Susan H. Lee in
Current site
Google Scholar
PubMed
Search for other papers by Susan H. Lee in
Current site
Google Scholar
PubMed
David F. McNeeley
David F. McNeeley
Division of Parasitic Diseases, National Center for Infectious Diseases, and Division of Field Epidemiology, Epidemiology Program Office, Centers for Disease Control, Sainte Croix Hospital, Atlanta, Georgia, Haiti
Search for other papers by David F. McNeeley in
Current site
Google Scholar
PubMed
Search for other papers by David F. McNeeley in
Current site
Google Scholar
PubMed
Harrison C. Spencer
Harrison C. Spencer
Division of Parasitic Diseases, National Center for Infectious Diseases, and Division of Field Epidemiology, Epidemiology Program Office, Centers for Disease Control, Sainte Croix Hospital, Atlanta, Georgia, Haiti
Search for other papers by Harrison C. Spencer in
Current site
Google Scholar
PubMed
Search for other papers by Harrison C. Spencer in
Current site
Google Scholar
PubMed
To compare the efficacy and tolerability of various combinations of low- and high-dose ivermectin and diethylcarbamazine (DEC), 59 persons with Wuchereria bancrofti microfilaremia were enrolled in a double-blinded six-arm clinical trial in Leogane, Haiti. On day 1, study participants were treated with low clearing doses of ivermectin, DEC, or placebo; on day 5 they received 200–400 µg/kg of ivermectin or 6 mg/kg of DEC. Adverse reactions, which were generally mild, occurred more frequently with ivermectin than with DEC. One year after treatment, the geometric mean microfilarial density returned to 0.9% of pretreatment levels for persons who received a total of 420 µg/kg of ivermectin. This rate was significantly lower than 5.6% for persons who were treated with 220 µg/kg of ivermectin (P = 0.02) and 9.3% for those receiving 6 or 7 mg/kg of DEC (P = 0.006). Persons treated with a clearing dose of ivermectin followed by 6 mg/kg of DEC also had low microfilarial densities (1.7% of pretreatment levels), suggesting an additive or synergistic effect of the two drugs. The addition of a clearing dose neither reduced the severity of adverse reactions nor improved the efficacy of high-dose ivermectin. Community-based intervention trials are now warranted to determine the feasibility and effectiveness of mass chemotherapy with single high-dose ivermectin for the prevention and control of lymphatic filariasis.
Author Notes
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1132 | 707 | 55 |
| Full Text Views | 26 | 3 | 0 |
| PDF Downloads | 29 | 4 | 0 |