| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 537 | 222 | 19 |
| Full Text Views | 6 | 1 | 0 |
| PDF Downloads | 7 | 2 | 0 |
Activity of Imidazoles Against Leishmania Tropica in Human Macrophage Cultures
Jonathan Dembitz Berman
Jonathan Dembitz Berman
Cell Biology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Department of Parasitology, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Bethesda, Maryland 20205
Search for other papers by Jonathan Dembitz Berman in
Current site
Google Scholar
PubMed
Search for other papers by Jonathan Dembitz Berman in
Current site
Google Scholar
PubMed
The anti-leishmanial activity of four imidazoles has been determined in Leishmania tropica-infected human monocyte-derived macrophage cultures. One of the imidazoles, hydrolyzed ketoconazole [cis-1-{4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxyphenyl}piperazine], eliminated 80 and 95% of the parasites at drug concentrations (2.0 and 2.5 µg/ml) that are achievable in vivo by a structurally similar compound, ketoconazole. These results demonstrate that an imidazole has anti-leishmanial activity in a model system, and suggests that hydrolyzed ketoconazole should be considered for in vivo trials in animal models of the disease.
Author Notes
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 537 | 222 | 19 |
| Full Text Views | 6 | 1 | 0 |
| PDF Downloads | 7 | 2 | 0 |