The Evaluation of Quinine Sulfate and Diaminodiphenyl Sulfone (DDS) as Suppressive Agents against Sporozoite-Induced Chesson Strain Vivax Malaria

William Chin Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, Malaria Project, U. S. Penitentiary, Atlanta, Georgia

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Peter G. Contacos Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, Malaria Project, U. S. Penitentiary, Atlanta, Georgia

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G. Robert Coatney Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, Malaria Project, U. S. Penitentiary, Atlanta, Georgia

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DOI:
https://doi.org/10.4269/ajtmh.1966.15.830
Volume/Issue:
Volume 15: Issue 6
Page(s):
830–832
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Summary

The evaluation of quinine sulfate and diaminodiphenyl sulfone (DDS) as suppressants against sporozoite-induced Chesson strain Plasmodium vivax is reported. The results indicate that quinine sulfate, 7.5 grams daily, is inadequate to offer complete protection in that 3 of 4 volunteers developed patent infections. DDS, when given in daily doses of 25 mg, failed to protect 5 of 5 volunteers.

Author Notes

Cytology Section, LPC, NIAID, NIH, P.O. Box 190, Chamblee, Georgia.

Professor of Pharmacology, Louisiana State University Medical School, New Orleans, Louisiana.

Copyright:
Copyright © 1966 By The American Society of Tropical Medicine and Hygiene 1966
Published Online:
Nov 1966
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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