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The Evaluation of Sulfonamides, Alone or in Combination with Pyrimethamine, in the Treatment of Multi-Resistant Falciparum Malaria
William Chin
William Chin
Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, Malaria Project, U. S. Penitentiary, Atlanta, Georgia
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Peter G. Contacos
Peter G. Contacos
Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, Malaria Project, U. S. Penitentiary, Atlanta, Georgia
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G. Robert Coatney
G. Robert Coatney
Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, Malaria Project, U. S. Penitentiary, Atlanta, Georgia
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Herschell K. King
Herschell K. King
Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, Malaria Project, U. S. Penitentiary, Atlanta, Georgia
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Summary
The evaluation of sulfadiazine, sulfamethoxypyridazine (Midicel®) and sulphorthomidine (Fanzil®) alone or combined with pyrimethamine against drug-resistant strains of Plasmodium falciparum is reported. The results indicate that (1) combination of a sulfonamide with pyrimethamine enhanced the curative effect of either one alone, (2) when combined with pyrimethamine, Midicel and Fanzil were superior to sulfadiazine, and (3) of the regimens tested, 1.0 g Fanzil as a single oral dose given together with 50 mg pyrimethamine showed the most promise for the successful treatment of the multi-drug-resistant falciparum malarias. Factors limiting the usefulness of sulfonamides as antimalarials are discussed.
Author Notes
Cytology Section, LPC, NIAID, NIH, P. O. Box 190, Chamblee, Georgia.
Present address: Department of Pharmacology, Louisiana State University, School of Medicine, New Orleans, Louisiana.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 689 | 377 | 45 |
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| PDF Downloads | 8 | 2 | 0 |