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Synthetic Antigens Derived from Plasmodium falciparum Sporozoite, Liver, and Blood Stages: Naturally Acquired Immune Response and Human Leukocyte Antigen Associations in Individuals Living in a Brazilian Endemic Area
Lilian Rose Pratt-Riccio
Lilian Rose Pratt-Riccio
Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil;
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Daiana De Souza Perce-Da-Silva
Daiana De Souza Perce-Da-Silva
Laboratório de Imunologia Clínica, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil;
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Josué Da Costa Lima-Junior
Josué Da Costa Lima-Junior
Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil;
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Evelyn Kety Pratt Riccio
Evelyn Kety Pratt Riccio
Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil;
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Marcelo Ribeiro-Alves
Marcelo Ribeiro-Alves
Laboratório de Pesquisa Clínica em DST/AIDS, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil;
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Fátima Santos
Fátima Santos
Laboratório Central de Saúde Pública (LACEN), Rondônia, Brazil;
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Mercia Arruda
Mercia Arruda
Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fiocruz, Recife, Brazil;
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Daniel Camus
Daniel Camus
Service de Parasitologie-Mycologie, Faculte de Médecine, Lille, France;
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Pierre Druilhe
Pierre Druilhe
VAC4ALL, Paris, France
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Joseli Oliveira-Ferreira
Joseli Oliveira-Ferreira
Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil;
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Cláudio Tadeu Daniel-Ribeiro
Cláudio Tadeu Daniel-Ribeiro
Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil;
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Dalma Maria Banic
Dalma Maria Banic
Laboratório de Imunologia Clínica, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil;
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Peptide vaccine strategies using Plasmodium-derived antigens have emerged as an attractive approach against malaria. However, relatively few studies have been conducted with malaria-exposed populations from non-African countries. Herein, the seroepidemiological profile against Plasmodium falciparum of naturally exposed individuals from a Brazilian malaria-endemic area against synthetic peptides derived from vaccine candidates circumsporozoite protein (CSP), liver stage antigen-1 (LSA-1), erythrocyte binding antigen-175 (EBA-175), and merozoite surface protein-3 (MSP-3) was investigated. Moreover, human leukocyte antigen (HLA)-DRB1* and HLA-DQB1* were evaluated to characterize genetic modulation of humoral responsiveness to these antigens. The study was performed using blood samples from 187 individuals living in rural malaria-endemic villages situated near Porto Velho, Rondônia State. Specific IgG and IgM antibodies and IgG subclasses were detected by enzyme-linked immunosorbent assay, and HLA-DRB1* and HLA-DQB1* low-resolution typing was performed by PCR-SSP. All four synthetic peptides were broadly recognized by naturally acquired antibodies. Regarding the IgG subclass profile, only CSP induced IgG1 and IgG3 antibodies, which is an important fact given that the acquisition of protective immunity appears to be associated with the cytophilicity of IgG1 and IgG3 antibodies. HLA-DRB1*11 and HLA-DQB1*7 had the lowest odds of responding to EBA-175. Our results showed that CSP, LSA-1, EBA, and MSP-3 are immunogenic in natural conditions of exposure and that anti-EBA antibody responses appear to be modulated by HLA class II antigens.
Author Notes
Financial support: This work was supported by the Instituto Oswaldo Cruz, Fiocruz, Brazil, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) Brazil and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. LRPR is supported by CNPq/PAPES (Programa de Apoio Pesquisa Estratégica em Saúde), Fiocruz. CTDR is a recipient of a Research Productivity Fellowship from CNPq and receives a grant from FAPERJ as “Cientista do Nosso Estado.”
Authors’ addresses: Lilian Rose Pratt-Riccio, Evelyn Kety Pratt Riccio, and Cláudio Tadeu Daniel-Ribeiro, Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil, E-mails: riccio@ioc.fiocruz.br, ericcio@ioc.fiocruz.br, and ctdr@uol.com.br. Daiana De Souza Perce-Da-Silva and Dalma Maria Banic, Laboratório de Imunologia Clínica, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil, E-mails: daiana@ioc.fiocruz.br and banic@ioc.fiocruz.br. Josué Da Costa Lima-Junior and Joseli Oliveira-Ferreira, Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil, E-mails: josue@ioc.fiocruz.br and lila@ioc.fiocruz.br. Marcelo Ribeiro-Alves, Laboratório de Pesquisa Clínica em DST/AIDS, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil, E-mail: mribalves1973@gmail.com. Fátima Santos, LACEN, Rondônia, Brazil, E-mail: fatsantosro@gmail.com. Mércia Arruda, Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fiocruz, Recife, Brazil, E-mail: merciaarruda@gmail.com. Daniel Camus, Service de Parasitologie-Mycologie, Faculte de Médecine, Lille, France, E-mail: daniel.camus@pasteur-lille.fr. Pierre Druilhe, VAC4ALL, Paris, France, E-mail: druilhe@vac4all.org.
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