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Reference Manager
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-
1.
Engel J Jr, Williamson PD, Wieser HG, 2008. Mesial temporal lobe epilepsy with hippocampal sclerosis. Engel J Jr., Pedley TA, eds. Epilepsy: A Comprehensive Textbook, 2nd edition. Philadelphia: Lippincott-Raven, 2479–2486.
-
2.
Dutras JR, Cortés EP, Vonsattel JPG, 2015. Update on hippocampal sclerosis. Curr Neurol Neurosci Rep 15: 67.
-
3.
Benbadis SR, Wallace J, Murtagh FR, Martinez C, Tatum WO, Vale FL, 2002. MRI evidence of mesial temporal sclerosis in subjects without seizures. Seizure 11: 340–343.
-
4.
Velasco TR, Zanello PA, Dalmagro CL, Araújo D Jr, Santos AC, Bianchin MM, Alexande V Jr, Walz R, Assirati JA, Carlotti GG Jr, Takayanagui OM, Sakamoto AC, Leite JP, 2006. Calcified cysticercosis lesions and intractable epilepsy: a cross sectional study of 512 patients. J Neurol Neurosurg Psychiatry 77: 485–488.
-
5.
Bianchin MM, Velasco TR, Coimbra ER, Gargaro AC, Escorsi-Rosset SR, Wichert-Ana L, Terra VC, Alexandre V Jr, Araujo D Jr, dos Santos AC, Fernandes RM, Assirati JA Jr, Carlotti GG Jr, Leite JP, Takayanagui OM, Markowitsch HJ, Sakamoto AC, 2013. Cognitive and surgical outcome in mesial temporal lobe epilepsy associated with hippocampal sclerosis plus neurocysticercosis: a cohort study. PLoS One 8: e60949.
-
6.
Bianchin MM, Velasco TR, Wichert-Ana L, Alexandre V Jr, Araujo D Jr, dos Santos AC, Carlotti GG Jr, Takayanagui OM, Sakamoto AC, 2014. Characteristics of mesial temporal lobe epilepsy associated with hippocampal sclerosis plus neurocysticercosis. Epilepsy Res 108: 1889–1895.
-
7.
Rathore C, Thomas B, Kesavadas C, Radhakrishnan K, 2012. Calcified neurocysticercosis lesions and hippocampal sclerosis: potential dual pathology? Epilepsia 53: e60–e62.
-
8.
Bianchin MM, Velasco TR, Santos AC, Sakamoto AC, 2012. On the relationship between neurocysticercosis and mesial temporal lobe epilepsy associated with hippocampal sclerosis: coincidence or a pathogenic relationship. Pathog Glob Health 106: 280–285.
-
9.
Del Brutto OH, Engel J Jr, Eliashiv DS, Salamon N, Garcia HH, 2014. Hippocampal sclerosis: the missing link of cysticercosis epileptogenesis? Epilepsia 55: 2077–2078.
-
10.
Del Brutto OH, Engel J Jr, Eliashiv DS, Garcia HH, 2016. Update on cysticercosis epileptogenesis: the role of the hippocampus. Curr Neurol Neurosci Rep 16: 1.
-
11.
Del Brutto OH, Salgado P, Lama J, Del Brutto VJ, Campos X, Zambrano M, Garcia HH, 2015. Calcified neurocysticercosis associates with hippocampal atrophy: a population-based Study. Am J Trop Med Hyg 91: 64–68.
-
12.
Del Brutto OH, Santibáñez R, Idrovo L, Rodríguez S, Díaz-Calderón E, Navas C, Gilman RH, Cuesta F, Mosquera A, Gonzalez AE, Tsang VC, García HH, 2005. Epilepsy and neurocysticercosis in Atahualpa: a door-to-door survey in rural coastal Ecuador. Epilepsia 46: 583–587.
-
13.
Kimura-Hayama ET, Higuera JA, Corona-Cedillo R, Chávez-Macias L, Perochena A, Quiroz-Rojas LY, Rodriguez-Carbajal J, Criales JL, 2010. Neurocysticercosis: radiologic-pathologic correlation. Radiographics 30: 1705–1719.
-
14.
Del Brutto OH, Rajshekhar V, White AC Jr, Tsang VC, Nash TE, Takayanagui OM, Schantz PM, Evans CA, Flisser A, Correa D, Botero D, Allan JC, Sarti E, Gonzalez AE, Gilman RH, Garcia HH, 2001. Proposed diagnostic criteria for neurocysticercosis. Neurology 57: 177–183.
-
15.
Scheltens PH, Leys D, Barkhof F, Huglo D, Weinstein HC, Vermersch P, Kuiper M, Steinling M, Wolters EC, Walk J, 1992. Atrophy of medial temporal lobes on MRI in “probable” Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry 55: 967–972.
-
16.
Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J, 2008. Helminth infections: the great neglected tropical diseases. J Clin Invest 118: 1311–1321.
-
17.
Del Brutto OH, Peñaherrera E, Ochoa E, Santamaría M, Zambrano M, Del Brutto VJ, 2014. Door-to-door survey of cardiovascular health, stroke, and ischemic heart disease in rural coastal Ecuador—The Atahualpa Project: methodology and operational definitions. Int J Stroke 9: 367–371.
-
18.
Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H, 2005. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53: 695–699.
-
19.
Del Brutto OH, Mera RM, Zambrano M, Soriano F, Lama J, 2015. Global cortical atrophy (GCA) associates with worse performance in the Montreal Cognitive Assessment (MoCA). A population-based study in community-dwelling elders living in rural Ecuador. Arch Gerontol Geriatr 60: 206–209.
-
20.
Del Brutto OH, Mera RM, Del Brutto VJ, Sedler MJ, 2016. The bicaudate index inversely associates with performance in the Montreal Cognitive Assessment (MoCA) in older adults living in rural Ecuador. The Atahualpa Project. Int J Geriatr Psychiatry 31: 944–950.
-
21.
Terra-Bustamante VC, Coimbra ER, Rezek KO, Escorsi-Rosset SR, Guarnieri R, Dalmagro CL, Inuzuka LM, Bianchin MM, Wichert-Ana L, Alexandre V, Takayanagui OM, Araújo D, dos Santos AC, Carlotti CG, Walz R, Markowitsch HJ, Sakamoto AC, 2005. Cognitive performance of patients with mesial temporal lobe epilepsy and incidental calcified neurocysticercosis. J Neurol Neurosurg Psychiatry 76: 1080–1083.
-
22.
Kawamura Y, Nakayama A, Kato T, Miura H, Ishihara N, Ihira M, Takahashi Y, Matsuda K, Yoshikawa T, 2015. Pathogenic role of human herpesvirus 6B infection in mesial temporal lobe epilepsy. Clin Infect Dis 212: 1014–1021.
-
23.
Leibovitch EC, Jacobson S, 2015. Human herpesvirus 6 as a trigger in mesial temporal lobe epilepsy. Clin Infect Dis 212: 1011–1013.
-
24.
Kahn MS, Kranjac D, Alonzo CA, Haase JH, Cedillos RO, McLinden KA, Boehm GW, Chumley MJ, 2012. Prolonged elevation in hippocampal Aβ and cognitive deficit following repeated endotoxin exposure in the mouse. Behav Brain Res 229: 176–184.
-
25.
Zepeda N, Solano S, Copitin N, Chávez JL, Fernández AM, García F, Tato P, Molinari JL, 2016. Apoptosis of mouse hippocampal cells induced by Taenia crassiceps metacestode factor. J Helminthol doi: https://doi.org/10.1017/S0022149X16000146.
-
26.
Boutet C, Chupin M, Colliot O, Sarazin M, Mutlu G, Drier A, Pellot A, Dormont D, Lehércy S; Alzheimer's Disease Neuroimaging Initiative, 2012. Is radiological evaluation as good as computer-based volumetry to assess hippocampal atrophy in Alzheimer's disease? Neuroradiology 54: 1321–1330.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 268 | 205 | 13 |
| Full Text Views | 485 | 17 | 1 |
| PDF Downloads | 233 | 12 | 1 |
The Association Between Neurocysticercosis and Hippocampal Atrophy is Related to Age
Oscar H. Del Brutto
Oscar H. Del Brutto
School of Medicine, Universidad Espíritu Santo–Ecuador, Guayaquil, Ecuador.
Department of Neurological Sciences, Hospital-Clínica Kennedy, Guayaquil, Ecuador.
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Department of Neurological Sciences, Hospital-Clínica Kennedy, Guayaquil, Ecuador.
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Naoum P. Issa
Naoum P. Issa
Department of Neurology, University of Chicago, Chicago, Illinois.
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Perla Salgado
Perla Salgado
Neuroimaging Unit, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez, Mexico City, Mexico.
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Victor J. Del Brutto
Victor J. Del Brutto
Department of Neurology, University of Chicago, Chicago, Illinois.
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Mauricio Zambrano
Mauricio Zambrano
Atahualpa Project, Community Center, Atahualpa, Ecuador.
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Julio Lama
Julio Lama
Imaging Department, Hospital-Clínica Kennedy, Guayaquil, Ecuador.
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Héctor H. García
Héctor H. García
Center for Global Health, Tumbes, Perú.
Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Perú.
Cysticercosis Unit, Instituto Nacional de Ciencias Neurológicas, Lima, Perú.
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Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Perú.
Cysticercosis Unit, Instituto Nacional de Ciencias Neurológicas, Lima, Perú.
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Neurocysticercosis (NCC) has been associated with hippocampal atrophy, but the prevalence and pathogenic mechanisms implicated in this relationship are unknown. Using a population-based, case–control study design, residents in a rural village (Atahualpa) aged ≥ 40 years with calcified NCC were identified as cases and paired to NCC-free individuals (control subjects) matched by age, sex, and level of education. Cases and control subjects underwent magnetic resonance imaging for hippocampal rating according to the Scheltens' scale for medial temporal atrophy and were interviewed to identify those with a clinical seizure disorder. The prevalence of hippocampal atrophy was compared between cases and control subjects by the use of the McNemar's test for correlated proportions. Seventy-five individuals with calcified NCC and their matched control subjects were included in the analysis. Hippocampal atrophy was noted in 26 (34.7%) cases and nine (12%) control subjects (odds ratio: 4.4; 95% confidence interval: 1.6–14.9, P < 0.0021). Stratification of pairs according to tertiles of age revealed an age-related trend in this association, which became significant only in those aged ≥ 68 years (P = 0.027). Only five cases and one control had recurrent seizures (P = 0.221); three of these five cases had hippocampal atrophy, and the single control subject had normal hippocampi. This study confirms an association between NCC and hippocampal atrophy, and shows that this association is stronger in older age groups. This suggests that NCC-related hippocampal atrophy takes a long time to develop.
Author Notes
Financial support: This study was partially supported by Universidad Espíritu Santo – Ecuador, Guayaquil – Ecuador. Hector H. Garcia is supported by a Wellcome Trust International Senior Fellowship in Public Health and Tropical Medicine.
Authors' addresses: Oscar H. Del Brutto, School of Medicine, Universidad Espíritu Santo–Ecuador, Guayaquil, Ecuador and Department of Neurological Sciences, Hospital-Clínica Kennedy, E-mail: oscardelbrutto@hotmail.com. Naoum P. Issa and Victor J. Del Brutto, Department of Neurology, University of Chicago, Chicago, IL, E-mails: naoum.issa@uchospitals.edu and vjdelbrutto@gmail.com. Perla Salgado, Neuroimaging Unit, National Institute of Neurology and Neurosurgery, Mexico City, Mexico, E-mail: pmtsalgado@yahoo.com.mx. Mauricio Zambrano, The Atahualpa Project, Community Center, Atahualpa, Ecuador, E-mail: zamaleon@hotmail.com. Julio Lama, Imaging Department, Hospital-Clínica Kennedy, Guayaquil, Ecuador, E-mail: julama54@hotmail.com. Héctor H. García, Department of Microbiologia, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru, Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Perú, and Cysticercosis Unit, Instituto Nacional de Ciencias Neurológicas, Lima, Perú, E-mail: hgarcia1@jhu.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Engel J Jr, Williamson PD, Wieser HG, 2008. Mesial temporal lobe epilepsy with hippocampal sclerosis. Engel J Jr., Pedley TA, eds. Epilepsy: A Comprehensive Textbook, 2nd edition. Philadelphia: Lippincott-Raven, 2479–2486.
-
2.
Dutras JR, Cortés EP, Vonsattel JPG, 2015. Update on hippocampal sclerosis. Curr Neurol Neurosci Rep 15: 67.
-
3.
Benbadis SR, Wallace J, Murtagh FR, Martinez C, Tatum WO, Vale FL, 2002. MRI evidence of mesial temporal sclerosis in subjects without seizures. Seizure 11: 340–343.
-
4.
Velasco TR, Zanello PA, Dalmagro CL, Araújo D Jr, Santos AC, Bianchin MM, Alexande V Jr, Walz R, Assirati JA, Carlotti GG Jr, Takayanagui OM, Sakamoto AC, Leite JP, 2006. Calcified cysticercosis lesions and intractable epilepsy: a cross sectional study of 512 patients. J Neurol Neurosurg Psychiatry 77: 485–488.
-
5.
Bianchin MM, Velasco TR, Coimbra ER, Gargaro AC, Escorsi-Rosset SR, Wichert-Ana L, Terra VC, Alexandre V Jr, Araujo D Jr, dos Santos AC, Fernandes RM, Assirati JA Jr, Carlotti GG Jr, Leite JP, Takayanagui OM, Markowitsch HJ, Sakamoto AC, 2013. Cognitive and surgical outcome in mesial temporal lobe epilepsy associated with hippocampal sclerosis plus neurocysticercosis: a cohort study. PLoS One 8: e60949.
-
6.
Bianchin MM, Velasco TR, Wichert-Ana L, Alexandre V Jr, Araujo D Jr, dos Santos AC, Carlotti GG Jr, Takayanagui OM, Sakamoto AC, 2014. Characteristics of mesial temporal lobe epilepsy associated with hippocampal sclerosis plus neurocysticercosis. Epilepsy Res 108: 1889–1895.
-
7.
Rathore C, Thomas B, Kesavadas C, Radhakrishnan K, 2012. Calcified neurocysticercosis lesions and hippocampal sclerosis: potential dual pathology? Epilepsia 53: e60–e62.
-
8.
Bianchin MM, Velasco TR, Santos AC, Sakamoto AC, 2012. On the relationship between neurocysticercosis and mesial temporal lobe epilepsy associated with hippocampal sclerosis: coincidence or a pathogenic relationship. Pathog Glob Health 106: 280–285.
-
9.
Del Brutto OH, Engel J Jr, Eliashiv DS, Salamon N, Garcia HH, 2014. Hippocampal sclerosis: the missing link of cysticercosis epileptogenesis? Epilepsia 55: 2077–2078.
-
10.
Del Brutto OH, Engel J Jr, Eliashiv DS, Garcia HH, 2016. Update on cysticercosis epileptogenesis: the role of the hippocampus. Curr Neurol Neurosci Rep 16: 1.
-
11.
Del Brutto OH, Salgado P, Lama J, Del Brutto VJ, Campos X, Zambrano M, Garcia HH, 2015. Calcified neurocysticercosis associates with hippocampal atrophy: a population-based Study. Am J Trop Med Hyg 91: 64–68.
-
12.
Del Brutto OH, Santibáñez R, Idrovo L, Rodríguez S, Díaz-Calderón E, Navas C, Gilman RH, Cuesta F, Mosquera A, Gonzalez AE, Tsang VC, García HH, 2005. Epilepsy and neurocysticercosis in Atahualpa: a door-to-door survey in rural coastal Ecuador. Epilepsia 46: 583–587.
-
13.
Kimura-Hayama ET, Higuera JA, Corona-Cedillo R, Chávez-Macias L, Perochena A, Quiroz-Rojas LY, Rodriguez-Carbajal J, Criales JL, 2010. Neurocysticercosis: radiologic-pathologic correlation. Radiographics 30: 1705–1719.
-
14.
Del Brutto OH, Rajshekhar V, White AC Jr, Tsang VC, Nash TE, Takayanagui OM, Schantz PM, Evans CA, Flisser A, Correa D, Botero D, Allan JC, Sarti E, Gonzalez AE, Gilman RH, Garcia HH, 2001. Proposed diagnostic criteria for neurocysticercosis. Neurology 57: 177–183.
-
15.
Scheltens PH, Leys D, Barkhof F, Huglo D, Weinstein HC, Vermersch P, Kuiper M, Steinling M, Wolters EC, Walk J, 1992. Atrophy of medial temporal lobes on MRI in “probable” Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry 55: 967–972.
-
16.
Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J, 2008. Helminth infections: the great neglected tropical diseases. J Clin Invest 118: 1311–1321.
-
17.
Del Brutto OH, Peñaherrera E, Ochoa E, Santamaría M, Zambrano M, Del Brutto VJ, 2014. Door-to-door survey of cardiovascular health, stroke, and ischemic heart disease in rural coastal Ecuador—The Atahualpa Project: methodology and operational definitions. Int J Stroke 9: 367–371.
-
18.
Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H, 2005. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53: 695–699.
-
19.
Del Brutto OH, Mera RM, Zambrano M, Soriano F, Lama J, 2015. Global cortical atrophy (GCA) associates with worse performance in the Montreal Cognitive Assessment (MoCA). A population-based study in community-dwelling elders living in rural Ecuador. Arch Gerontol Geriatr 60: 206–209.
-
20.
Del Brutto OH, Mera RM, Del Brutto VJ, Sedler MJ, 2016. The bicaudate index inversely associates with performance in the Montreal Cognitive Assessment (MoCA) in older adults living in rural Ecuador. The Atahualpa Project. Int J Geriatr Psychiatry 31: 944–950.
-
21.
Terra-Bustamante VC, Coimbra ER, Rezek KO, Escorsi-Rosset SR, Guarnieri R, Dalmagro CL, Inuzuka LM, Bianchin MM, Wichert-Ana L, Alexandre V, Takayanagui OM, Araújo D, dos Santos AC, Carlotti CG, Walz R, Markowitsch HJ, Sakamoto AC, 2005. Cognitive performance of patients with mesial temporal lobe epilepsy and incidental calcified neurocysticercosis. J Neurol Neurosurg Psychiatry 76: 1080–1083.
-
22.
Kawamura Y, Nakayama A, Kato T, Miura H, Ishihara N, Ihira M, Takahashi Y, Matsuda K, Yoshikawa T, 2015. Pathogenic role of human herpesvirus 6B infection in mesial temporal lobe epilepsy. Clin Infect Dis 212: 1014–1021.
-
23.
Leibovitch EC, Jacobson S, 2015. Human herpesvirus 6 as a trigger in mesial temporal lobe epilepsy. Clin Infect Dis 212: 1011–1013.
-
24.
Kahn MS, Kranjac D, Alonzo CA, Haase JH, Cedillos RO, McLinden KA, Boehm GW, Chumley MJ, 2012. Prolonged elevation in hippocampal Aβ and cognitive deficit following repeated endotoxin exposure in the mouse. Behav Brain Res 229: 176–184.
-
25.
Zepeda N, Solano S, Copitin N, Chávez JL, Fernández AM, García F, Tato P, Molinari JL, 2016. Apoptosis of mouse hippocampal cells induced by Taenia crassiceps metacestode factor. J Helminthol doi: https://doi.org/10.1017/S0022149X16000146.
-
26.
Boutet C, Chupin M, Colliot O, Sarazin M, Mutlu G, Drier A, Pellot A, Dormont D, Lehércy S; Alzheimer's Disease Neuroimaging Initiative, 2012. Is radiological evaluation as good as computer-based volumetry to assess hippocampal atrophy in Alzheimer's disease? Neuroradiology 54: 1321–1330.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 268 | 205 | 13 |
| Full Text Views | 485 | 17 | 1 |
| PDF Downloads | 233 | 12 | 1 |