Sohn YM, 2000. Japanese encephalitis immunization in South Korea: past, present, and future. Emerg Infect Dis 6: 17–24.
Kyle JL, Harris E, 2008. Global spread and persistence of dengue. Annu Rev Microbiol 62: 71–92.
WHO, 2009. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. Geneva: World Health Organization.
Gubler DJ, Meltzer M, 1999. Impact of dengue/dengue hemorrhagic fever on the developing world. Adv Virus Res 53: 35–70.
EDCD, 2005. Annual Report: 2002 and 2003. Nepal: Epidemiology and Disease Control Division (EDCD), Department of Health Services, Ministry of Health and Population, Kathmandu.
Bista MB, Shrestha JM, 2005. Epidemiological situation of Japanese encephalitis in Nepal. JNMA J Nepal Med Assoc 44: 51–56.
WHO, 2003. WHO-Recommended Standards for Surveillance of Selected Vaccine-Preventable Diseases. Geneva: World Health Organization.
Wierzba TF, Ghimire P, Malla S, Banerjee MK, Shrestha S, Khanal B, Sedai TR, Gibbons RV, 2008. Laboratory-based Japanese encephalitis surveillance in Nepal and the implications for a national immunization strategy. Am J Trop Med Hyg 78: 1002–1006.
Malla S, Thakur GD, Shrestha SK, Banjeree MK, Thapa LB, Gongal G, Ghimire P, Upadhyay BP, Gautam P, Khanal S, Nisaluk A, Jarman RG, Gibbons RV, 2008. Identification of all dengue serotypes in Nepal. Emerg Infect Dis 14: 1669–1670.
Pandey BD, Morita K, Khanal SR, Takasaki T, Miyazaki I, Ogawa T, Inoue S, Kurane I, 2008. Dengue virus, Nepal. Emerg Infect Dis 14: 514–515.
Malla S, Ghimire P, Dumre S, Khanal SP, Subedi BK, Wierzba TF, 2005. A First Report of Dengue Fever Cases in Nepal. Health Action in Nepal: Health Newsletter. Available at: http://www.who.int/hac/crises/npl/sitreps/2005/Nepal_Health_Action_Issue_III.pdf. Accessed May 1, 2012.
Innis BL, Nisalak A, Nimmannitya S, Kusalerdchariya S, Chongswasdi V, Suntayakorn S, Puttisri P, Hoke CH, 1989. An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate. Am J Trop Med Hyg 40: 418–427.
WHO, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment and Control. Geneva: World Health Organization.
Bista MB, Banerjee MK, Shin SH, Tandan JB, Kim MH, Sohn YM, Ohrr HC, Tang JL, Halstead SB, 2001. Efficacy of single-dose SA 14-14-2 vaccine against Japanese encephalitis: a case control study. Lancet 358: 791–795.
Ohrr H, Tandan JB, Sohn YM, Shin SH, Pradhan DP, Halstead SB, 2005. Effect of single dose of SA 14-14-2 vaccine 1 year after immunisation in Nepalese children with Japanese encephalitis: a case-control study. Lancet 366: 1375–1378.
Tandan JB, Ohrr H, Sohn YM, Yoksan S, Ji M, Nam CM, Halstead SB, 2007. Single dose of SA 14-14-2 vaccine provides long-term protection against Japanese encephalitis: a case-control study in Nepalese children 5 years after immunization. Vaccine 25: 5041–5045.
WHO, 2011. World Health Organization Country Office for Nepal. National Immunization Programme: Routine Immunization. Available at: http://www.nep.searo.who.int/EN/Section4/Section29/Section89.htm. Accessed May 1, 2012.
Tripathi P, Kumar R, Tripathi S, Tambe JJ, Venkatesh V, 2008. Descriptive epidemiology of dengue transmission in Uttar Pradesh. Indian Pediatr 45: 315–318.
WHO, 2007. Outbreak Investigation in Nepal. South East Asia Regional Office, New Delhi, India: World Health Organization. Available at: http://209.61.208.233/LinkFiles/Dengue_dengue_Nepal.pdf. Accessed May 14, 2012.
Gautam I, Dhimal MN, Shrestha SR, Tamrakar AS, 2009. First record of Aedes aegypti (L.) vector of dengue virus from Kathmandu, Nepal. Journal of Natural History Museum 24: 156–164.
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We report on the changing epidemiology of two important flaviviruses in Nepal: Japanese encephalitis (JE) and dengue viruses. Morbidity and mortality in Nepal is in the thousands since JE was introduced in 1978. Nepal launched an extensive laboratory-based JE surveillance in 2004. Nepal experienced a remarkable reduction in disease burden after mass immunizations from 2005 to 2010, when 2,040 JE infections and 205 JE-related deaths were confirmed. With its emergence in 2006, dengue has become a significant challenge in the country, highlighted by a sudden outbreak in 2010 that resulted in 359 confirmed dengue infections. Currently, both viruses cocirculate in Nepal. Here, we document the remarkable expansion of dengue in Nepal, which urgently requires national surveillance to refine the burden and make recommendations regarding control and prevention programs. We believe that the use of existing JE surveillance network for integrated dengue surveillance may represent the most appropriate alternative.
Financial support: The dengue component of this study was partly supported by World Health Organization—Special Program for Research and Training in Topical Diseases, Geneva, Switzerland Leadership Training Grant A80350 (to S.P.D.).
Authors' addresses: Shyam P. Dumre, Kesara Na-Bangchang, Veerachai Eursitthichai, and Hans Rudi Grams, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand, E-mails: shyamprad@hotmail.com, kesaratmu@yahoo.com, veebkk@gmail.com, and rgrams@alfa.ac.th. Geeta Shakya and Khagendra KC, National Public Health Laboratory, Ministry of Health and Population, Kathmandu, Nepal, E-mails: nphl@wlink.com.np and khaggu17@hotmail.com. Senendra R. Upreti, Ministry of Health and Population, Kathmandu, Nepal, E-mail: senendraupreti933@hotmail.com. Prakash Ghimire, Central Department of Microbiology, Tribhuwan University, Kathmandu, Nepal, E-mail: prakashghimire@yahoo.com. Ananda Nisalak, Robert V. Gibbons, and Stefan Fernandez, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand, E-mails: anandan@afrims.org, robert.gibbons@afrims.org, and stefan.fernandez@afrims.org.
Sohn YM, 2000. Japanese encephalitis immunization in South Korea: past, present, and future. Emerg Infect Dis 6: 17–24.
Kyle JL, Harris E, 2008. Global spread and persistence of dengue. Annu Rev Microbiol 62: 71–92.
WHO, 2009. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. Geneva: World Health Organization.
Gubler DJ, Meltzer M, 1999. Impact of dengue/dengue hemorrhagic fever on the developing world. Adv Virus Res 53: 35–70.
EDCD, 2005. Annual Report: 2002 and 2003. Nepal: Epidemiology and Disease Control Division (EDCD), Department of Health Services, Ministry of Health and Population, Kathmandu.
Bista MB, Shrestha JM, 2005. Epidemiological situation of Japanese encephalitis in Nepal. JNMA J Nepal Med Assoc 44: 51–56.
WHO, 2003. WHO-Recommended Standards for Surveillance of Selected Vaccine-Preventable Diseases. Geneva: World Health Organization.
Wierzba TF, Ghimire P, Malla S, Banerjee MK, Shrestha S, Khanal B, Sedai TR, Gibbons RV, 2008. Laboratory-based Japanese encephalitis surveillance in Nepal and the implications for a national immunization strategy. Am J Trop Med Hyg 78: 1002–1006.
Malla S, Thakur GD, Shrestha SK, Banjeree MK, Thapa LB, Gongal G, Ghimire P, Upadhyay BP, Gautam P, Khanal S, Nisaluk A, Jarman RG, Gibbons RV, 2008. Identification of all dengue serotypes in Nepal. Emerg Infect Dis 14: 1669–1670.
Pandey BD, Morita K, Khanal SR, Takasaki T, Miyazaki I, Ogawa T, Inoue S, Kurane I, 2008. Dengue virus, Nepal. Emerg Infect Dis 14: 514–515.
Malla S, Ghimire P, Dumre S, Khanal SP, Subedi BK, Wierzba TF, 2005. A First Report of Dengue Fever Cases in Nepal. Health Action in Nepal: Health Newsletter. Available at: http://www.who.int/hac/crises/npl/sitreps/2005/Nepal_Health_Action_Issue_III.pdf. Accessed May 1, 2012.
Innis BL, Nisalak A, Nimmannitya S, Kusalerdchariya S, Chongswasdi V, Suntayakorn S, Puttisri P, Hoke CH, 1989. An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate. Am J Trop Med Hyg 40: 418–427.
WHO, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment and Control. Geneva: World Health Organization.
Bista MB, Banerjee MK, Shin SH, Tandan JB, Kim MH, Sohn YM, Ohrr HC, Tang JL, Halstead SB, 2001. Efficacy of single-dose SA 14-14-2 vaccine against Japanese encephalitis: a case control study. Lancet 358: 791–795.
Ohrr H, Tandan JB, Sohn YM, Shin SH, Pradhan DP, Halstead SB, 2005. Effect of single dose of SA 14-14-2 vaccine 1 year after immunisation in Nepalese children with Japanese encephalitis: a case-control study. Lancet 366: 1375–1378.
Tandan JB, Ohrr H, Sohn YM, Yoksan S, Ji M, Nam CM, Halstead SB, 2007. Single dose of SA 14-14-2 vaccine provides long-term protection against Japanese encephalitis: a case-control study in Nepalese children 5 years after immunization. Vaccine 25: 5041–5045.
WHO, 2011. World Health Organization Country Office for Nepal. National Immunization Programme: Routine Immunization. Available at: http://www.nep.searo.who.int/EN/Section4/Section29/Section89.htm. Accessed May 1, 2012.
Tripathi P, Kumar R, Tripathi S, Tambe JJ, Venkatesh V, 2008. Descriptive epidemiology of dengue transmission in Uttar Pradesh. Indian Pediatr 45: 315–318.
WHO, 2007. Outbreak Investigation in Nepal. South East Asia Regional Office, New Delhi, India: World Health Organization. Available at: http://209.61.208.233/LinkFiles/Dengue_dengue_Nepal.pdf. Accessed May 14, 2012.
Gautam I, Dhimal MN, Shrestha SR, Tamrakar AS, 2009. First record of Aedes aegypti (L.) vector of dengue virus from Kathmandu, Nepal. Journal of Natural History Museum 24: 156–164.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 339 | 290 | 20 |
Full Text Views | 538 | 12 | 1 |
PDF Downloads | 162 | 10 | 1 |