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-
1
Portaels F, Meyers WM, Ablordey A, Castro AG, Chemlal K, de Rijk P, Elsen P, Fissette K, Fraga AG, Lee R, Mahrous E, Small PL, Stragier P, Torrado E, Van Aerde A, Silva MT, Pedrosa J, 2008. First cultivation and characterization of Mycobacterium ulcerans from the environment. PLoS Negl Trop Dis 2 :e178.
-
2
Durnez L, Eddyani M, Mgode GF, Katakweba A, Katholi CR, Machang’u RR, Kazwala RR, Portaels F, Leirs H, 2008. First detection of mycobacteria in African rodents and insectivores, using stratified pool screening. Appl Environ Microbiol 74 :768–773.
-
3
Johnson PD, Azuolas J, Lavender CJ, Wishart E, Stinear TP, Hayman JA, Brown L, Jenkin GA, Fyfe JA, 2007. Mycobacterium ulcerans in mosquitoes captured during outbreak of Buruli ulcer, southeastern Australia. Emerg Infect Dis 13 :1653–1660.
-
4
Marsollier L, Robert R, Aubry J, Saint Andre JP, Kouakou H, Legras P, Manceau AL, Mahaza C, Carbonnelle B, 2002. Aquatic insects as a vector for Mycobacterium ulcerans.Appl Environ Microbiol 68 :4623–4628.
-
5
Portaels F, Chemlal K, Elsen P, Johnson PD, Hayman JA, Hibble J, Kirkwood R, Meyers WM, 2001. Mycobacterium ulcerans in wild animals. Rev Sci Tech 20 :252–264.
-
6
Williamson HR, Benbow ME, Nguyen KD, Beachboard DC, Kimbirauskas RK, McIntosh MD, Quaye C, Ampadu EO, Boakye D, Merritt RW, Small PL, 2008. Distribution of Mycobacterium ulcerans in Buruli ulcer endemic and non-endemic aquatic sites in Ghana. PLoS Negl Trop Dis 2 :e205.
-
7
Benbow ME, Williamson H, Kimbirauskas R, McIntosh MD, Kolar R, Quaye C, Akpabey F, Boakye D, Small P, Merritt RW, 2008. Aquatic invertebrates as unlikely vectors of Buruli ulcer disease. Emerg Infect Dis 14 :1247–1254.
-
8
Debacker M, Portaels F, Aguiar J, Steunou C, Zinsou C, Meyers W, Dramaix M, 2006. Risk factors for Buruli ulcer, Benin. Emerg Infect Dis 12 :1325–1331.
-
9
Pouillot R, Matias G, Wondje CM, Portaels F, Valin N, Ngos F, Njikap A, Marsollier L, Fontanet A, Eyangoh S, 2007. Risk factors for Buruli ulcer: a case control study in Cameroon. PLoS Negl Trop Dis 1 :e101.
-
10
Raghunathan PL, Whitney EA, Asamoa K, Stienstra Y, Taylor THJ, Amofah GK, Ofori-Adjei D, Dobos KM, Guarner J, Kihlstrom SL, Pathak S, Klutse E, Etuaful S, Quarshie E, van der Graaf WT, van der Werf TS, King CH, Tappero JW, Ashford DA, 2005. Risk factors for Buruli ulcer disease (Mycobacterium ulcerans infection): results from a case-control study in Ghana. Clin Infect Dis 40 :1445–1453.
-
11
van der Werf TS, Stienstra Y, Johnson RC, Phillips R, Adjei O, Fleischer B, Wansbrough-Jones MH, Johnson PD, Portaels F, van der Graaf WT, Asiedu K, 2005. Mycobacterium ulcerans disease. Bull World Health Organ 83 :785–791.
-
12
Aujoulat I, Johnson C, Zinsou C, Guédénon A, Portaels F, 2003. Psychosocial aspects of health seeking behaviours of patients with Buruli ulcer in southern Benin. Trop Med Int Health 8 :750–759.
-
13
Stienstra Y, van der Graaf WTA, Asamoa K, van der Werf TS, 2002. Beliefs and attitudes towards Buruli ulcer Ghana. Am J Trop Med Hyg 67 :207–213.
-
14
van der Werf TS, van der Graaf WTA, Tappero JW, Asiedu K, 1999. Mycobacterium ulcerans infection. Lancet 354 :1013–1018.
-
15
Aguiar J, Stenou C, 1997. Les ulcères de Buruli en zone rurale au Bénin: prise en charge de 635 cas. Med Trop 57 :83–90.
-
16
Asiedu K, Etuaful S, 1998. Socioeconomic implications of Buruli ulcer in Ghana: a three-year review. Am J Trop Med Hyg 59 :1015–1022.
-
17
Ouattara D, Meningaud JP, Kaba L, Sica A, Asse H, 2004. Traitement de l’ulcère de Buruli par excision-greffe: à propos de 118 observations. Ann Chir Plast Esthet 49 :11–16.
-
18
Etuaful S, Carbonnelle B, Grosset J, Lucas S, Horsfield C, Phillips R, Evans M, Ofori-Adjei D, Klustse E, Owusu-Boateng J, Amedofu GK, Awuah P, Ampadu E, Amofah G, Asiedu K, Wansbrough-Jones M, 2005. Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans. Antimicrob Agents Chemother 49 :3182–3186.
-
19
van der Werf TS, Stinear T, Stienstra Y, van der Graaf WT, Small PL, 2003. Mycolactones and Mycobacterium ulcerans disease. Lancet 362 :1062–1064.
-
20
George KM, Chatterjee D, Gunawardana G, Welty D, Hayman J, Lee R, Small PL, 1999. Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence. Science 283 :854–857.
-
21
Chauty A, Ardant MF, Adeye A, Euverte H, Guedenon A, Johnson C, Aubry J, Nuermberger E, Grosset J, 2007. Promising clinical efficacy of the combination streptomycin-rifampin for the treatment of Buruli ulcer (Mycobacterium ulcerans disease). Antimicrob Agents Chemother 51 :4029–4035.
-
22
Ellen DE, Stienstra Y, Teelken MA, Dijkstra PE, van der Graaf WT, van der Werf TS, 2003. Assessment of functional limitations caused by Mycobacterium ulcerans infection: towards a Buruli ulcer functional limitations score. Trop Med Int Health 8 :90–96.
-
23
Stienstra Y, Dijkstra PU, Guedenon A, Johnson RC, Ampadu EO, Mensah T, Klutse EY, Etuaful S, Deepak S, van der Graaf WT, van der Werf TS, 2004. Development of a questionnaire assessing Buruli ulcer-induced functional limitation. Am J Trop Med Hyg 70 :318–322.
-
24
Stienstra Y, Dijkstra PU, van Wezel MJ, van Roest MH, Beets M, Zijlstra IJ, Johnson RC, Ampadu EO, Gbovi J, Zinsou C, Etuaful S, Klutse EY, van der Graaf WT, van der Werf TS, 2005. Reliability and validity of the Buruli ulcer functional limitation score questionnaire. Am J Trop Med Hyg 72 :449–452.
-
25
Stienstra Y, van Roest MH, van Wezel MJ, Wiersma IC, Hospers IC, Dijkstra PU, Johnson RC, Ampadu EO, Gbovi J, Zinsou C, Etuaful S, Klutse EY, van der Graaf WT, van der Werf TS, 2005. Factors associated with functional limitations and subsequent employment or schooling in Buruli ulcer patients. Trop Med Int Health 10 :1251–1257.
-
26
Teelken MA, Stienstra Y, Ellen DE, Quarshie E, Klutse E, van der Graaf WT, van der Werf TS, 2003. Buruli ulcer: differences in treatment outcome between two centres in Ghana. Acta Trop 88 :51–56.
-
27
Debacker M, Aguiar J, Steunou C, Zinsou C, Meyers WM, Guedenon A, Scott JT, Dramaix M, Portaels F, 2004. Mycobacterium ulcerans disease (Buruli ulcer) in rural hospital, Southern Benin, 1997–2001. Emerg Infect Dis 10 :1391–1398.
-
28
Renzaho AM, Woods PV, Ackumey MM, Harvey SK, Kotin J, 2007. Community-based study on knowledge, attitude and practice on the mode of transmission, prevention and treatment of the Buruli ulcer in Ga West District, Ghana. Trop Med Int Health 12 :445–458.
-
29
Kassah AK, 1998. Community-based rehabilitation and stigma management by physically disabled people in Ghana. Disabil Rehabil 20 :66–73.
-
30
Tinney MJ, Chiodo A, Haig A, Wiredu E, 2007. Medical rehabilitation in Ghana. Disabil Rehabil 29 :921–927.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 138 | 116 | 8 |
| Full Text Views | 206 | 7 | 0 |
| PDF Downloads | 67 | 8 | 0 |
Functional Limitations after Surgical or Antibiotic Treatment for Buruli Ulcer in Benin
Yves Barogui
Yves Barogui
Programme National Lutte contre la Lèpre et l’Ulcère de Buruli, Ministère de la Santé, Cotonou, République du Bénin; Departments of Internal Medicine and Pulmonary Diseases and Tuberculosis, Infectious Diseases and Tuberculosis Service, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands; Department of Rehabilitation, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands
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R. Christian Johnson
R. Christian Johnson
Programme National Lutte contre la Lèpre et l’Ulcère de Buruli, Ministère de la Santé, Cotonou, République du Bénin; Departments of Internal Medicine and Pulmonary Diseases and Tuberculosis, Infectious Diseases and Tuberculosis Service, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands; Department of Rehabilitation, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands
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Tjip S. van der Werf
Tjip S. van der Werf
Programme National Lutte contre la Lèpre et l’Ulcère de Buruli, Ministère de la Santé, Cotonou, République du Bénin; Departments of Internal Medicine and Pulmonary Diseases and Tuberculosis, Infectious Diseases and Tuberculosis Service, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands; Department of Rehabilitation, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands
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Ghislain Sopoh
Ghislain Sopoh
Programme National Lutte contre la Lèpre et l’Ulcère de Buruli, Ministère de la Santé, Cotonou, République du Bénin; Departments of Internal Medicine and Pulmonary Diseases and Tuberculosis, Infectious Diseases and Tuberculosis Service, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands; Department of Rehabilitation, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands
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Ange Dossou
Ange Dossou
Programme National Lutte contre la Lèpre et l’Ulcère de Buruli, Ministère de la Santé, Cotonou, République du Bénin; Departments of Internal Medicine and Pulmonary Diseases and Tuberculosis, Infectious Diseases and Tuberculosis Service, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands; Department of Rehabilitation, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands
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Pieter U. Dijkstra
Pieter U. Dijkstra
Programme National Lutte contre la Lèpre et l’Ulcère de Buruli, Ministère de la Santé, Cotonou, République du Bénin; Departments of Internal Medicine and Pulmonary Diseases and Tuberculosis, Infectious Diseases and Tuberculosis Service, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands; Department of Rehabilitation, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands
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Ymkje Stienstra
Ymkje Stienstra
Programme National Lutte contre la Lèpre et l’Ulcère de Buruli, Ministère de la Santé, Cotonou, République du Bénin; Departments of Internal Medicine and Pulmonary Diseases and Tuberculosis, Infectious Diseases and Tuberculosis Service, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands; Department of Rehabilitation, University Medical Centre Groningen, University of Groningen, RB Groningen, The Netherlands
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Almost half of patients have functional limitations after treatment of Buruli ulcer disease. Antibiotic treatment (along with surgery) was introduced in the National Program for Buruli ulcer in Benin in 2005. The aim of this study was to compare functional limitations in patients who were treated by antibiotics, surgery, or both, using a validated questionnaire. One hundred seventy-nine former patients in Lalo, Benin were retrieved and interviewed in their village. Hospital records were used to gather data about size of lesion at presentation and treatment provided. No significant differences in resulting functional limitations were found between the different treatments. Larger lesions (> 15 cm cross-sectional diameter) at presentation; lesions on a joint, muscular atrophy, and amputation were all associated with a higher risk for functional limitations. Advantages of antibiotic treatment may involve other domains, like costs of treatment or a change in help-seeking behavior.
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-
1
Portaels F, Meyers WM, Ablordey A, Castro AG, Chemlal K, de Rijk P, Elsen P, Fissette K, Fraga AG, Lee R, Mahrous E, Small PL, Stragier P, Torrado E, Van Aerde A, Silva MT, Pedrosa J, 2008. First cultivation and characterization of Mycobacterium ulcerans from the environment. PLoS Negl Trop Dis 2 :e178.
-
2
Durnez L, Eddyani M, Mgode GF, Katakweba A, Katholi CR, Machang’u RR, Kazwala RR, Portaels F, Leirs H, 2008. First detection of mycobacteria in African rodents and insectivores, using stratified pool screening. Appl Environ Microbiol 74 :768–773.
-
3
Johnson PD, Azuolas J, Lavender CJ, Wishart E, Stinear TP, Hayman JA, Brown L, Jenkin GA, Fyfe JA, 2007. Mycobacterium ulcerans in mosquitoes captured during outbreak of Buruli ulcer, southeastern Australia. Emerg Infect Dis 13 :1653–1660.
-
4
Marsollier L, Robert R, Aubry J, Saint Andre JP, Kouakou H, Legras P, Manceau AL, Mahaza C, Carbonnelle B, 2002. Aquatic insects as a vector for Mycobacterium ulcerans.Appl Environ Microbiol 68 :4623–4628.
-
5
Portaels F, Chemlal K, Elsen P, Johnson PD, Hayman JA, Hibble J, Kirkwood R, Meyers WM, 2001. Mycobacterium ulcerans in wild animals. Rev Sci Tech 20 :252–264.
-
6
Williamson HR, Benbow ME, Nguyen KD, Beachboard DC, Kimbirauskas RK, McIntosh MD, Quaye C, Ampadu EO, Boakye D, Merritt RW, Small PL, 2008. Distribution of Mycobacterium ulcerans in Buruli ulcer endemic and non-endemic aquatic sites in Ghana. PLoS Negl Trop Dis 2 :e205.
-
7
Benbow ME, Williamson H, Kimbirauskas R, McIntosh MD, Kolar R, Quaye C, Akpabey F, Boakye D, Small P, Merritt RW, 2008. Aquatic invertebrates as unlikely vectors of Buruli ulcer disease. Emerg Infect Dis 14 :1247–1254.
-
8
Debacker M, Portaels F, Aguiar J, Steunou C, Zinsou C, Meyers W, Dramaix M, 2006. Risk factors for Buruli ulcer, Benin. Emerg Infect Dis 12 :1325–1331.
-
9
Pouillot R, Matias G, Wondje CM, Portaels F, Valin N, Ngos F, Njikap A, Marsollier L, Fontanet A, Eyangoh S, 2007. Risk factors for Buruli ulcer: a case control study in Cameroon. PLoS Negl Trop Dis 1 :e101.
-
10
Raghunathan PL, Whitney EA, Asamoa K, Stienstra Y, Taylor THJ, Amofah GK, Ofori-Adjei D, Dobos KM, Guarner J, Kihlstrom SL, Pathak S, Klutse E, Etuaful S, Quarshie E, van der Graaf WT, van der Werf TS, King CH, Tappero JW, Ashford DA, 2005. Risk factors for Buruli ulcer disease (Mycobacterium ulcerans infection): results from a case-control study in Ghana. Clin Infect Dis 40 :1445–1453.
-
11
van der Werf TS, Stienstra Y, Johnson RC, Phillips R, Adjei O, Fleischer B, Wansbrough-Jones MH, Johnson PD, Portaels F, van der Graaf WT, Asiedu K, 2005. Mycobacterium ulcerans disease. Bull World Health Organ 83 :785–791.
-
12
Aujoulat I, Johnson C, Zinsou C, Guédénon A, Portaels F, 2003. Psychosocial aspects of health seeking behaviours of patients with Buruli ulcer in southern Benin. Trop Med Int Health 8 :750–759.
-
13
Stienstra Y, van der Graaf WTA, Asamoa K, van der Werf TS, 2002. Beliefs and attitudes towards Buruli ulcer Ghana. Am J Trop Med Hyg 67 :207–213.
-
14
van der Werf TS, van der Graaf WTA, Tappero JW, Asiedu K, 1999. Mycobacterium ulcerans infection. Lancet 354 :1013–1018.
-
15
Aguiar J, Stenou C, 1997. Les ulcères de Buruli en zone rurale au Bénin: prise en charge de 635 cas. Med Trop 57 :83–90.
-
16
Asiedu K, Etuaful S, 1998. Socioeconomic implications of Buruli ulcer in Ghana: a three-year review. Am J Trop Med Hyg 59 :1015–1022.
-
17
Ouattara D, Meningaud JP, Kaba L, Sica A, Asse H, 2004. Traitement de l’ulcère de Buruli par excision-greffe: à propos de 118 observations. Ann Chir Plast Esthet 49 :11–16.
-
18
Etuaful S, Carbonnelle B, Grosset J, Lucas S, Horsfield C, Phillips R, Evans M, Ofori-Adjei D, Klustse E, Owusu-Boateng J, Amedofu GK, Awuah P, Ampadu E, Amofah G, Asiedu K, Wansbrough-Jones M, 2005. Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans. Antimicrob Agents Chemother 49 :3182–3186.
-
19
van der Werf TS, Stinear T, Stienstra Y, van der Graaf WT, Small PL, 2003. Mycolactones and Mycobacterium ulcerans disease. Lancet 362 :1062–1064.
-
20
George KM, Chatterjee D, Gunawardana G, Welty D, Hayman J, Lee R, Small PL, 1999. Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence. Science 283 :854–857.
-
21
Chauty A, Ardant MF, Adeye A, Euverte H, Guedenon A, Johnson C, Aubry J, Nuermberger E, Grosset J, 2007. Promising clinical efficacy of the combination streptomycin-rifampin for the treatment of Buruli ulcer (Mycobacterium ulcerans disease). Antimicrob Agents Chemother 51 :4029–4035.
-
22
Ellen DE, Stienstra Y, Teelken MA, Dijkstra PE, van der Graaf WT, van der Werf TS, 2003. Assessment of functional limitations caused by Mycobacterium ulcerans infection: towards a Buruli ulcer functional limitations score. Trop Med Int Health 8 :90–96.
-
23
Stienstra Y, Dijkstra PU, Guedenon A, Johnson RC, Ampadu EO, Mensah T, Klutse EY, Etuaful S, Deepak S, van der Graaf WT, van der Werf TS, 2004. Development of a questionnaire assessing Buruli ulcer-induced functional limitation. Am J Trop Med Hyg 70 :318–322.
-
24
Stienstra Y, Dijkstra PU, van Wezel MJ, van Roest MH, Beets M, Zijlstra IJ, Johnson RC, Ampadu EO, Gbovi J, Zinsou C, Etuaful S, Klutse EY, van der Graaf WT, van der Werf TS, 2005. Reliability and validity of the Buruli ulcer functional limitation score questionnaire. Am J Trop Med Hyg 72 :449–452.
-
25
Stienstra Y, van Roest MH, van Wezel MJ, Wiersma IC, Hospers IC, Dijkstra PU, Johnson RC, Ampadu EO, Gbovi J, Zinsou C, Etuaful S, Klutse EY, van der Graaf WT, van der Werf TS, 2005. Factors associated with functional limitations and subsequent employment or schooling in Buruli ulcer patients. Trop Med Int Health 10 :1251–1257.
-
26
Teelken MA, Stienstra Y, Ellen DE, Quarshie E, Klutse E, van der Graaf WT, van der Werf TS, 2003. Buruli ulcer: differences in treatment outcome between two centres in Ghana. Acta Trop 88 :51–56.
-
27
Debacker M, Aguiar J, Steunou C, Zinsou C, Meyers WM, Guedenon A, Scott JT, Dramaix M, Portaels F, 2004. Mycobacterium ulcerans disease (Buruli ulcer) in rural hospital, Southern Benin, 1997–2001. Emerg Infect Dis 10 :1391–1398.
-
28
Renzaho AM, Woods PV, Ackumey MM, Harvey SK, Kotin J, 2007. Community-based study on knowledge, attitude and practice on the mode of transmission, prevention and treatment of the Buruli ulcer in Ga West District, Ghana. Trop Med Int Health 12 :445–458.
-
29
Kassah AK, 1998. Community-based rehabilitation and stigma management by physically disabled people in Ghana. Disabil Rehabil 20 :66–73.
-
30
Tinney MJ, Chiodo A, Haig A, Wiredu E, 2007. Medical rehabilitation in Ghana. Disabil Rehabil 29 :921–927.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 138 | 116 | 8 |
| Full Text Views | 206 | 7 | 0 |
| PDF Downloads | 67 | 8 | 0 |