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1
Organización Panamericana de la Salud, 1995. Dengue y Dengue Hemorrágico en las Américas: Guías para su Prevención y Control. Washington, DC: Organización Panamericana de la Salud. Publicación Científica 548: 110.
-
2
Gubler D, 1998. J. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 11 :480–496.
-
3
Rigau-Pérez JG, Clark GG, Gubler DJ, Reiter P, Sanders EJ, Vorndam AV, 1998. Dengue and dengue haemorrhagic fever. Lancet 352 :971–977.
-
4
Siqueira JB Jr, Martelli CM, Coelho GE, Simplicio AC, Hatch DL, 2005. Dengue and dengue hemorrhagic fever, Brazil, 1981–2002. Emerg Infect Dis 11 :48–53.
-
5
SIVIGILA, 2002. Comportamiento por Regiones del Dengue en el 2001. Boletín Epidemiológico Semanal. Semana epidemiológica No. 02. Enero 06 a 12 de 2002. Available at: www.col.ops-oms.org/sivigila/2002/BOLE02_02.htm.
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6
Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, Viramitrachi W, Ratanachueke S, Kiatpolpoj S, Innis BL, Rothman AL, Nisalak A, Ennis FA, 1997. Early clinical and laboratory indicators of acute dengue illness. J Infect Dis 176 :313–321.
-
7
Monath TP, 1997. Early indicators in acute dengue infection. Lancet 350 :1719–1720.
-
8
Wang LY, Chang WY, Lu SN, Chen TP, 1990. Sequential changes of serum transaminase and abdominal sonography in patients with suspected dengue fever. Kao Hsiung I Hsueh Tsa Chih 6 :483–489.
-
9
Nguyen TL, Nguyen TH, Tieu NT, 1997. The impact of dengue hemorrhagic fever on liver function. Res Virol 148 :273–277.
-
10
Kuo CH, Tai DI, Chang-Chien CS, Lan CK, Chiou SS, Liaw YF, 1992. Liver biochemical tests and dengue fever. Am J Trop Med Hyg 47 :265–270.
-
11
Alvarez ME, Ramirez-Ronda CH, 1985. Dengue and hepatic failure. Am J Med 79 :670–674.
-
12
Ray G, Kumar V, Kapoor AK, Dutta AK, Batra S, 1999. Status of antioxidants and other biochemical abnormalities in children with dengue fever. J Trop Pediatr 45 :4–7.
-
13
Setiawan MW, Samsi TK, Wulur H, Sugianto D, Pool TN, 1998. Epigastric pain and sonographic assessment of the pancreas in dengue hemorrhagic fever. J Clin Ultrasound 26 :257–259.
-
14
Jusuf H, Sudjana P, Djumhana A, Abdurachman SA, 1998. DHF with complication of acute pancreatitis related hyperglycemia: a case report. Southeast Asian J Trop Med Public Health 29 :367–369.
-
15
Krippner R, Hanish G, Kretschmer H, 1990. Dengue fever with hemorrhagic manifestations after a stay in Thailand. Dtsch Med Wochenschr 115 :858–862.
-
16
Gascon J, Giner V, Vidal J, Jou JM, Mas E, Corachan M, 1998. Dengue: a re-emerging disease. A clinical and epidemiological study in 57 Spanish travelers. Med Clin (Barc) 111 :583–586.
-
17
Malheiros SM, Oliveira AS, Schmidt B, Lima JG, Gabbai AA, 1993. Dengue. Muscle biopsy findings in 15 patients. Arq Neuropsiquiatr 15 :159–164.
-
18
Nevalainen TJ, 1993. Serum phospholipases A2 in inflammatory diseases. Clin Chem 39 :2453–2459.
-
19
Nevalainen TJ, Losacker W, 1997. Serum phospholipase A2 in dengue. J Infect 35 :251–252.
-
20
SIVIGILA, 2003. Enfermedades de Notificación Obligatoria. Informe Primer Semestre de 2003. Boletín Epidemiológico Semanal. Semana epidemiológica No. 26. Junio 22–28 de 2003. Available at: www.col.ops-oms.org/sivigila/2003/BOLE26_03.pdf.
-
21
Organización Panamericana de la Salud, 2000. Definiciones de casos. Dengue. Boletín Epidemiológico 21 :14–15.
-
22
Rigau-Perez JG, Bonilla GL, 1999. An evaluation of modified case definitions for the detection of dengue hemorrhagic fever. Puerto Rico Association of Epidemiologists. P R Health Sci J 18 :347–352.
-
23
Díaz-Quijano FA, Martínez-Vega RA, Villar-Centeno LA, 2005. Indicadores de severidad en dengue. Enferm Infecc Microbiol Clin 23 :529–532.
-
24
Agrawal DK, Tandon P, Chaturvedi UC, Kumar A, 1978. Biochemical study of certain enzymes and metabolites of the carbohydrate metabolism in the skeletal muscle of the dengue virus-infected mice. J Gen Virol 40 :399–408.
-
25
Korones DN, Brown MR, Palis J, 2001. “Liver function tests” are not always tests of liver function. Am J Hematol 66 :46–48.
-
26
Mohanty S, Mishra SK, Das BS, Satpathy SK, Mohanty D, Patnaik JK, Bose TK, 1992. Altered plasma lipid pattern in falciparum malaria. Ann Trop Med Parasitol 86 :601–606.
-
27
Parola P, Gazin P, Patella F, Badiaga S, Delmont J, Brouqui P, 2004. Hypertriglyceridemia as an indicator of the severity of falciparum malaria in returned travelers: a clinical retrospective study. Parasitol Res 92 :464–466.
-
28
Garbagnati E, 1993. Changes in lipid profile observed in children over the course of infectious disease. Acta Paediatr 82 :948–952.
-
29
Gallin JI, Kaye D, O’Leary WM, 1969. Serum lipids in infection. N Engl J Med 281 :1081–1086.
-
30
Van Gorp EC, Suharti C, Mairuhu AT, Dolmans WM, van Der Ven J, Demacker PN, van Deer Meer JW, 2002. Changes in the plasma lipid profile as a potential predictor of clinical outcome in dengue hemorrhagic fever. Clin Infect Dis 34 :1150–1153.
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31
Thisyakorn U, Nimmannitya S, 1993. Nutritional status of children with dengue hemorrhagic fever. Clin Infect Dis 16 :295–297.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 304 | 237 | 16 |
| Full Text Views | 414 | 5 | 1 |
| PDF Downloads | 166 | 7 | 1 |
Biochemical Alterations as Markers of Dengue Hemorrhagic Fever
Luis Angel Villar-Centeno
Luis Angel Villar-Centeno
School of Medicine, and Centro de Investigaciones Epidemiológicas, Universidad Industrial de Santander, Bucaramanga, Colombia
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Fredi Alexander Díaz-Quijano
Fredi Alexander Díaz-Quijano
School of Medicine, and Centro de Investigaciones Epidemiológicas, Universidad Industrial de Santander, Bucaramanga, Colombia
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Ruth Aralí Martínez-Vega
Ruth Aralí Martínez-Vega
School of Medicine, and Centro de Investigaciones Epidemiológicas, Universidad Industrial de Santander, Bucaramanga, Colombia
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We evaluated biochemical alterations as predictors of dengue hemorrhagic fever (DHF). Patients with confirmed infection with dengue virus were prospectively evaluated for the first seven days of disease to determine their final clinical outcome. Serum samples taken 48–96 hours after onset of fever were used for biochemical tests. Of 199 patients, 30 developed DHF. Cases of DHF had higher levels of lactate dehydrogenase (LDH), creatine kinase (CK), and aspartate aminotransferase, and lower levels of albumin, total cholesterol, and triglycerides. Multivariate analysis showed that early alterations of CK (hazard ratio [HR] = 6.98, 95% confidence interval [CI] = 2.34–20.85, P = 0.001), LDH (HR = 3.19, 95% CI = 1.01–10.12, P < 0.05), and albumin (HR = 2.54, 95% CI = 1.09–5.92, P = 0.03) were associated with DHF. Triglyceride levels > 160 mg/dL were negatively associated with developing DHF (HR = 0.07, 95% CI = 0.01–0.59, P = 0.01). Early alterations of biochemical markers can predict DHF in patients with acute fever caused by dengue.
Author Notes
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-
1
Organización Panamericana de la Salud, 1995. Dengue y Dengue Hemorrágico en las Américas: Guías para su Prevención y Control. Washington, DC: Organización Panamericana de la Salud. Publicación Científica 548: 110.
-
2
Gubler D, 1998. J. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 11 :480–496.
-
3
Rigau-Pérez JG, Clark GG, Gubler DJ, Reiter P, Sanders EJ, Vorndam AV, 1998. Dengue and dengue haemorrhagic fever. Lancet 352 :971–977.
-
4
Siqueira JB Jr, Martelli CM, Coelho GE, Simplicio AC, Hatch DL, 2005. Dengue and dengue hemorrhagic fever, Brazil, 1981–2002. Emerg Infect Dis 11 :48–53.
-
5
SIVIGILA, 2002. Comportamiento por Regiones del Dengue en el 2001. Boletín Epidemiológico Semanal. Semana epidemiológica No. 02. Enero 06 a 12 de 2002. Available at: www.col.ops-oms.org/sivigila/2002/BOLE02_02.htm.
-
6
Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, Viramitrachi W, Ratanachueke S, Kiatpolpoj S, Innis BL, Rothman AL, Nisalak A, Ennis FA, 1997. Early clinical and laboratory indicators of acute dengue illness. J Infect Dis 176 :313–321.
-
7
Monath TP, 1997. Early indicators in acute dengue infection. Lancet 350 :1719–1720.
-
8
Wang LY, Chang WY, Lu SN, Chen TP, 1990. Sequential changes of serum transaminase and abdominal sonography in patients with suspected dengue fever. Kao Hsiung I Hsueh Tsa Chih 6 :483–489.
-
9
Nguyen TL, Nguyen TH, Tieu NT, 1997. The impact of dengue hemorrhagic fever on liver function. Res Virol 148 :273–277.
-
10
Kuo CH, Tai DI, Chang-Chien CS, Lan CK, Chiou SS, Liaw YF, 1992. Liver biochemical tests and dengue fever. Am J Trop Med Hyg 47 :265–270.
-
11
Alvarez ME, Ramirez-Ronda CH, 1985. Dengue and hepatic failure. Am J Med 79 :670–674.
-
12
Ray G, Kumar V, Kapoor AK, Dutta AK, Batra S, 1999. Status of antioxidants and other biochemical abnormalities in children with dengue fever. J Trop Pediatr 45 :4–7.
-
13
Setiawan MW, Samsi TK, Wulur H, Sugianto D, Pool TN, 1998. Epigastric pain and sonographic assessment of the pancreas in dengue hemorrhagic fever. J Clin Ultrasound 26 :257–259.
-
14
Jusuf H, Sudjana P, Djumhana A, Abdurachman SA, 1998. DHF with complication of acute pancreatitis related hyperglycemia: a case report. Southeast Asian J Trop Med Public Health 29 :367–369.
-
15
Krippner R, Hanish G, Kretschmer H, 1990. Dengue fever with hemorrhagic manifestations after a stay in Thailand. Dtsch Med Wochenschr 115 :858–862.
-
16
Gascon J, Giner V, Vidal J, Jou JM, Mas E, Corachan M, 1998. Dengue: a re-emerging disease. A clinical and epidemiological study in 57 Spanish travelers. Med Clin (Barc) 111 :583–586.
-
17
Malheiros SM, Oliveira AS, Schmidt B, Lima JG, Gabbai AA, 1993. Dengue. Muscle biopsy findings in 15 patients. Arq Neuropsiquiatr 15 :159–164.
-
18
Nevalainen TJ, 1993. Serum phospholipases A2 in inflammatory diseases. Clin Chem 39 :2453–2459.
-
19
Nevalainen TJ, Losacker W, 1997. Serum phospholipase A2 in dengue. J Infect 35 :251–252.
-
20
SIVIGILA, 2003. Enfermedades de Notificación Obligatoria. Informe Primer Semestre de 2003. Boletín Epidemiológico Semanal. Semana epidemiológica No. 26. Junio 22–28 de 2003. Available at: www.col.ops-oms.org/sivigila/2003/BOLE26_03.pdf.
-
21
Organización Panamericana de la Salud, 2000. Definiciones de casos. Dengue. Boletín Epidemiológico 21 :14–15.
-
22
Rigau-Perez JG, Bonilla GL, 1999. An evaluation of modified case definitions for the detection of dengue hemorrhagic fever. Puerto Rico Association of Epidemiologists. P R Health Sci J 18 :347–352.
-
23
Díaz-Quijano FA, Martínez-Vega RA, Villar-Centeno LA, 2005. Indicadores de severidad en dengue. Enferm Infecc Microbiol Clin 23 :529–532.
-
24
Agrawal DK, Tandon P, Chaturvedi UC, Kumar A, 1978. Biochemical study of certain enzymes and metabolites of the carbohydrate metabolism in the skeletal muscle of the dengue virus-infected mice. J Gen Virol 40 :399–408.
-
25
Korones DN, Brown MR, Palis J, 2001. “Liver function tests” are not always tests of liver function. Am J Hematol 66 :46–48.
-
26
Mohanty S, Mishra SK, Das BS, Satpathy SK, Mohanty D, Patnaik JK, Bose TK, 1992. Altered plasma lipid pattern in falciparum malaria. Ann Trop Med Parasitol 86 :601–606.
-
27
Parola P, Gazin P, Patella F, Badiaga S, Delmont J, Brouqui P, 2004. Hypertriglyceridemia as an indicator of the severity of falciparum malaria in returned travelers: a clinical retrospective study. Parasitol Res 92 :464–466.
-
28
Garbagnati E, 1993. Changes in lipid profile observed in children over the course of infectious disease. Acta Paediatr 82 :948–952.
-
29
Gallin JI, Kaye D, O’Leary WM, 1969. Serum lipids in infection. N Engl J Med 281 :1081–1086.
-
30
Van Gorp EC, Suharti C, Mairuhu AT, Dolmans WM, van Der Ven J, Demacker PN, van Deer Meer JW, 2002. Changes in the plasma lipid profile as a potential predictor of clinical outcome in dengue hemorrhagic fever. Clin Infect Dis 34 :1150–1153.
-
31
Thisyakorn U, Nimmannitya S, 1993. Nutritional status of children with dengue hemorrhagic fever. Clin Infect Dis 16 :295–297.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 304 | 237 | 16 |
| Full Text Views | 414 | 5 | 1 |
| PDF Downloads | 166 | 7 | 1 |