ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
World Health Organization, 2000. Buruli Ulcer-Mycobacterium ulcerans Infection. Asiedu K, Scherpbier R, Raviglione M, eds. Geneva: World Health Organization. WHO/CDS/CPE/GUI/2001.1.
-
2
World Health Organization, 2004. Buruli ulcer disease. Mycobacterium ulcerans infection: an overview of reported cases globally. Wkly Epidemiol Rec 79 :194–200.
-
3
Van Oye E, Ballion M, 1950. Faudra-t-il tenir compte d’une nou-velle affection à bacilles acido-résistants en Afrique? (Note préliminaire). Ann Soc Belg Med Trop 30 :619–621.
-
4
Janssens PG, 1972. Skin ulcers caused by acid-fast bacilli. Marshall J, ed. Essays in Dermatology.Volume 2. Amsterdam: Excerpta Medica: 264–295.
-
5
Meyers WM, Connor DH, McCullough B, Bourland J, Moris R, Proos L, 1974. Distribution of Mycobacterium ulcerans infections in Zaïre, including the report of new foci. Ann Soc Belg Med Trop 54 :147–157.
-
6
Andersen FO, 1965. Mycobacterial skin ulcers. Clinical experience. Cent Afr J Med 11 :131–135.
-
7
Smith JH, 1970. Epidemiologic observations in cases of Buruli ulcer seen in a hospital in the lower Congo. Am J Trop Med Hyg 19 :657–663.
-
8
Bafende AE, Lukanu NP, Numbi AN, 2002. Buruli ulcer in an AIDS patient: case report. S Afr Med J 92 :437.
-
9
Kibadi K, Tsakala TM, Mputu-Yamba JB, Kashongwe M, Muyembe T, Imposo BB, 2002. Essai thérapeutique de l’association chloramine-métronidazole-nitrofurantoine dans l’ulcère de Buruli surinfecté. Med Afr Noire 49 :239–243.
-
10
Bafende AE, Phanzu MD, Imposo BB, 2004. Buruli ulcer in the Democratic Republic of Congo: epidemiology, presentation and outcome. Trop Doc 34 :82–84.
-
11
Portaels F, 1989. Epidémiologie des ulcères à Mycobacterium ulcerans. Ann Soc Belg Med Trop 69 :91–103.
-
12
Kibadi K, Tsakala TM, Mputu-Yamba JB, Muyembe T, Kashongwe M, Imposo B, Nsiala A, 2003. L’ulcère de Buruli chez les réfugiés Angolais des sites de Kimpese, Bas-Congo, RD Congo. Cahiers Santé 13 :39–41.
-
13
World Health Organization, 2001. Buruli Ulcer. Diagnosis of Mycobacterium ulcerans Disease. Portaels F, Johnson P, Meyers WM, eds. Geneva: World Health Organization. WHO/CDS/CPE/GBUI/2001.4.
-
14
Pettit JHS, Marchette NJ, Rees RJW, 1966. Mycobacterium ulcerans infection. Clinical and bacteriological study of the first cases recognized in south east Asia. Br J Dermatol 78 :187–197.
-
15
Portaels F, Aguiar J, Fissette K, Fonteyne PA, De Beenhouwer H, De Rijk P, Guédénon A, Lemans R, Steunou C, Zinsou C, Dumonceau JM, Meyers WM, 1997. Direct detection and identification of Mycobacterium ulcerans in clinical specimens by PCR and oligonucleotide-specific capture plate hybridization. J Clin Microbiol 35 :1097–1100.
-
16
Yeboah-Manu D, Bodmer T, Mensah-Quainoo E, Owusu S, Ofori-Adjei D, Pluschke G, 2004. Evaluation of decontamination methods and growth media for primary isolation of Mycobacterium ulcerans from surgical specimens. J Clin Microbiol 42 :5875–5876.
-
17
Debacker M, Aguiar J, Stenou C, Zinsou C, Meyers WM, Guédénon A, Scott JT, Dramaix M, Portaels F, 2004. Mycobacterium ulcerans disease (Buruli ulcer) in rural hospital, southern Benin, 1997–2001. Emerg Infect Dis 10 :1391–1398.
-
18
Debacker M, Aguiar J, Stenou C, Zinsou C, Meyers WM, Scott JT, Dramaix M, Portaels F, 2004. Mycobacterium ulcerans disease: role of age and gender in incidence and morbidity. Trop Med Int Health 9 :1297–1304.
-
19
Bär W, Rüsch-Gerdes S, Richter E, Marquéz de Bär G, Dittmer C, Papsdorf H, Stosiek P, de Rijk PB, Meyers WM, Portaels F, 1998. Mycobacterium ulcerans infection in a child from Angola: diagnosis by direct detection and culture. Trop Med Int Health 3 :189–196.
-
20
Pszolla N, Sarkar MR, Strecker W, Kern P, Kinzl L, Meyers WM, Portaels F, 2003. Buruli ulcer: A systemic disease. Clin Infect Dis 37 :e78–e82.
-
21
Suykerbuyk P, Phanzu MD, Polman K, Bafende E, Meirte D, Leirs H, Trefois P, Portaels F, 2004. The potential role of freshwater snails, aquatic insects, fish, rodents, lizards and amphibians as reservoirs for Mycobacterium ulcerans. Eighth Maastricht Medical Students Research Conference. Maastricht, The Netherlands: University of Maastricht.
-
22
Portaels F, Zinsou C, Aguiar J, Debacker M, de Biurrun E, Guédénon A, Josse R, Lagarrigue V, Silva MT, Steunou C, Meyers WM, 2003. Les atteintes osseuses dans l’ulcère de Buruli: à propos de 73 cas. Bull Seanc Acad R Sci Outre Mer 49 :161–190.
-
23
Debacker M, Aguiar J, Steunou C, Zinsou C, Meyers WM, Portaels F, 2005. Buruli ulcer recurrence, Benin. Emerg Infect Dis 11 :584–589.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 127 | 101 | 9 |
| Full Text Views | 253 | 4 | 1 |
| PDF Downloads | 65 | 4 | 1 |
MYCOBACTERIUM ULCERANS DISEASE (BURULI ULCER) IN A RURAL HOSPITAL IN BAS-CONGO, DEMOCRATIC REPUBLIC OF CONGO, 2002–2004
DELPHIN M. PHANZU
DELPHIN M. PHANZU
Institut Médical Evangélique, Kimpese Hospital, Kimpese, Bas-Congo, Democratic Republic of Congo; Programme National de Lutte contre l’Ulcère de Buruli, Kinshasa, Democratic Republic of Congo; Armed Forces Institute of Pathology, Washington, District of Columbia; Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
Search for other papers by DELPHIN M. PHANZU in
Current site
Google Scholar
PubMed
Search for other papers by DELPHIN M. PHANZU in
Current site
Google Scholar
PubMed
ERIC A. BAFENDE
ERIC A. BAFENDE
Institut Médical Evangélique, Kimpese Hospital, Kimpese, Bas-Congo, Democratic Republic of Congo; Programme National de Lutte contre l’Ulcère de Buruli, Kinshasa, Democratic Republic of Congo; Armed Forces Institute of Pathology, Washington, District of Columbia; Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
Search for other papers by ERIC A. BAFENDE in
Current site
Google Scholar
PubMed
Search for other papers by ERIC A. BAFENDE in
Current site
Google Scholar
PubMed
BARTHELEMY K. DUNDA
BARTHELEMY K. DUNDA
Institut Médical Evangélique, Kimpese Hospital, Kimpese, Bas-Congo, Democratic Republic of Congo; Programme National de Lutte contre l’Ulcère de Buruli, Kinshasa, Democratic Republic of Congo; Armed Forces Institute of Pathology, Washington, District of Columbia; Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
Search for other papers by BARTHELEMY K. DUNDA in
Current site
Google Scholar
PubMed
Search for other papers by BARTHELEMY K. DUNDA in
Current site
Google Scholar
PubMed
DESIRE B. IMPOSO
DESIRE B. IMPOSO
Institut Médical Evangélique, Kimpese Hospital, Kimpese, Bas-Congo, Democratic Republic of Congo; Programme National de Lutte contre l’Ulcère de Buruli, Kinshasa, Democratic Republic of Congo; Armed Forces Institute of Pathology, Washington, District of Columbia; Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
Search for other papers by DESIRE B. IMPOSO in
Current site
Google Scholar
PubMed
Search for other papers by DESIRE B. IMPOSO in
Current site
Google Scholar
PubMed
ANATOLE K. KIBADI
ANATOLE K. KIBADI
Institut Médical Evangélique, Kimpese Hospital, Kimpese, Bas-Congo, Democratic Republic of Congo; Programme National de Lutte contre l’Ulcère de Buruli, Kinshasa, Democratic Republic of Congo; Armed Forces Institute of Pathology, Washington, District of Columbia; Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
Search for other papers by ANATOLE K. KIBADI in
Current site
Google Scholar
PubMed
Search for other papers by ANATOLE K. KIBADI in
Current site
Google Scholar
PubMed
SAMUEL Z. NSIANGANA
SAMUEL Z. NSIANGANA
Institut Médical Evangélique, Kimpese Hospital, Kimpese, Bas-Congo, Democratic Republic of Congo; Programme National de Lutte contre l’Ulcère de Buruli, Kinshasa, Democratic Republic of Congo; Armed Forces Institute of Pathology, Washington, District of Columbia; Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
Search for other papers by SAMUEL Z. NSIANGANA in
Current site
Google Scholar
PubMed
Search for other papers by SAMUEL Z. NSIANGANA in
Current site
Google Scholar
PubMed
JACKIE N. SINGA
JACKIE N. SINGA
Institut Médical Evangélique, Kimpese Hospital, Kimpese, Bas-Congo, Democratic Republic of Congo; Programme National de Lutte contre l’Ulcère de Buruli, Kinshasa, Democratic Republic of Congo; Armed Forces Institute of Pathology, Washington, District of Columbia; Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
Search for other papers by JACKIE N. SINGA in
Current site
Google Scholar
PubMed
Search for other papers by JACKIE N. SINGA in
Current site
Google Scholar
PubMed
WAYNE M. MEYERS
WAYNE M. MEYERS
Institut Médical Evangélique, Kimpese Hospital, Kimpese, Bas-Congo, Democratic Republic of Congo; Programme National de Lutte contre l’Ulcère de Buruli, Kinshasa, Democratic Republic of Congo; Armed Forces Institute of Pathology, Washington, District of Columbia; Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
Search for other papers by WAYNE M. MEYERS in
Current site
Google Scholar
PubMed
Search for other papers by WAYNE M. MEYERS in
Current site
Google Scholar
PubMed
PATRICK SUYKERBUYK
PATRICK SUYKERBUYK
Institut Médical Evangélique, Kimpese Hospital, Kimpese, Bas-Congo, Democratic Republic of Congo; Programme National de Lutte contre l’Ulcère de Buruli, Kinshasa, Democratic Republic of Congo; Armed Forces Institute of Pathology, Washington, District of Columbia; Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
Search for other papers by PATRICK SUYKERBUYK in
Current site
Google Scholar
PubMed
Search for other papers by PATRICK SUYKERBUYK in
Current site
Google Scholar
PubMed
FRANÇOISE PORTAELS
FRANÇOISE PORTAELS
Institut Médical Evangélique, Kimpese Hospital, Kimpese, Bas-Congo, Democratic Republic of Congo; Programme National de Lutte contre l’Ulcère de Buruli, Kinshasa, Democratic Republic of Congo; Armed Forces Institute of Pathology, Washington, District of Columbia; Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
Search for other papers by FRANÇOISE PORTAELS in
Current site
Google Scholar
PubMed
Search for other papers by FRANÇOISE PORTAELS in
Current site
Google Scholar
PubMed
Buruli ulcer (BU), which is caused by Mycobacterium ulcerans, is an important disabling skin disease. Its prevalence is highest in west and central Africa. We report an apparent resurgence of BU in the Bas-Congo Province, Democratic Republic of Congo. During a 28-month period in 2002–2004, the rural hospital of the Institut Médical Evangélique at Kimpese admitted 51 patients suspected of having BU. Bacteriologic, molecular biologic, and histopathologic studies confirmed BU in 36 of these patients. Extensive clinical data, treatment outcomes, and socioeconomic correlations are summarized. Osteomyelitis was an important complication. A multidisciplinary approach to BU control in the Bas-Congo is proposed, aimed primarily at active case detection.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
World Health Organization, 2000. Buruli Ulcer-Mycobacterium ulcerans Infection. Asiedu K, Scherpbier R, Raviglione M, eds. Geneva: World Health Organization. WHO/CDS/CPE/GUI/2001.1.
-
2
World Health Organization, 2004. Buruli ulcer disease. Mycobacterium ulcerans infection: an overview of reported cases globally. Wkly Epidemiol Rec 79 :194–200.
-
3
Van Oye E, Ballion M, 1950. Faudra-t-il tenir compte d’une nou-velle affection à bacilles acido-résistants en Afrique? (Note préliminaire). Ann Soc Belg Med Trop 30 :619–621.
-
4
Janssens PG, 1972. Skin ulcers caused by acid-fast bacilli. Marshall J, ed. Essays in Dermatology.Volume 2. Amsterdam: Excerpta Medica: 264–295.
-
5
Meyers WM, Connor DH, McCullough B, Bourland J, Moris R, Proos L, 1974. Distribution of Mycobacterium ulcerans infections in Zaïre, including the report of new foci. Ann Soc Belg Med Trop 54 :147–157.
-
6
Andersen FO, 1965. Mycobacterial skin ulcers. Clinical experience. Cent Afr J Med 11 :131–135.
-
7
Smith JH, 1970. Epidemiologic observations in cases of Buruli ulcer seen in a hospital in the lower Congo. Am J Trop Med Hyg 19 :657–663.
-
8
Bafende AE, Lukanu NP, Numbi AN, 2002. Buruli ulcer in an AIDS patient: case report. S Afr Med J 92 :437.
-
9
Kibadi K, Tsakala TM, Mputu-Yamba JB, Kashongwe M, Muyembe T, Imposo BB, 2002. Essai thérapeutique de l’association chloramine-métronidazole-nitrofurantoine dans l’ulcère de Buruli surinfecté. Med Afr Noire 49 :239–243.
-
10
Bafende AE, Phanzu MD, Imposo BB, 2004. Buruli ulcer in the Democratic Republic of Congo: epidemiology, presentation and outcome. Trop Doc 34 :82–84.
-
11
Portaels F, 1989. Epidémiologie des ulcères à Mycobacterium ulcerans. Ann Soc Belg Med Trop 69 :91–103.
-
12
Kibadi K, Tsakala TM, Mputu-Yamba JB, Muyembe T, Kashongwe M, Imposo B, Nsiala A, 2003. L’ulcère de Buruli chez les réfugiés Angolais des sites de Kimpese, Bas-Congo, RD Congo. Cahiers Santé 13 :39–41.
-
13
World Health Organization, 2001. Buruli Ulcer. Diagnosis of Mycobacterium ulcerans Disease. Portaels F, Johnson P, Meyers WM, eds. Geneva: World Health Organization. WHO/CDS/CPE/GBUI/2001.4.
-
14
Pettit JHS, Marchette NJ, Rees RJW, 1966. Mycobacterium ulcerans infection. Clinical and bacteriological study of the first cases recognized in south east Asia. Br J Dermatol 78 :187–197.
-
15
Portaels F, Aguiar J, Fissette K, Fonteyne PA, De Beenhouwer H, De Rijk P, Guédénon A, Lemans R, Steunou C, Zinsou C, Dumonceau JM, Meyers WM, 1997. Direct detection and identification of Mycobacterium ulcerans in clinical specimens by PCR and oligonucleotide-specific capture plate hybridization. J Clin Microbiol 35 :1097–1100.
-
16
Yeboah-Manu D, Bodmer T, Mensah-Quainoo E, Owusu S, Ofori-Adjei D, Pluschke G, 2004. Evaluation of decontamination methods and growth media for primary isolation of Mycobacterium ulcerans from surgical specimens. J Clin Microbiol 42 :5875–5876.
-
17
Debacker M, Aguiar J, Stenou C, Zinsou C, Meyers WM, Guédénon A, Scott JT, Dramaix M, Portaels F, 2004. Mycobacterium ulcerans disease (Buruli ulcer) in rural hospital, southern Benin, 1997–2001. Emerg Infect Dis 10 :1391–1398.
-
18
Debacker M, Aguiar J, Stenou C, Zinsou C, Meyers WM, Scott JT, Dramaix M, Portaels F, 2004. Mycobacterium ulcerans disease: role of age and gender in incidence and morbidity. Trop Med Int Health 9 :1297–1304.
-
19
Bär W, Rüsch-Gerdes S, Richter E, Marquéz de Bär G, Dittmer C, Papsdorf H, Stosiek P, de Rijk PB, Meyers WM, Portaels F, 1998. Mycobacterium ulcerans infection in a child from Angola: diagnosis by direct detection and culture. Trop Med Int Health 3 :189–196.
-
20
Pszolla N, Sarkar MR, Strecker W, Kern P, Kinzl L, Meyers WM, Portaels F, 2003. Buruli ulcer: A systemic disease. Clin Infect Dis 37 :e78–e82.
-
21
Suykerbuyk P, Phanzu MD, Polman K, Bafende E, Meirte D, Leirs H, Trefois P, Portaels F, 2004. The potential role of freshwater snails, aquatic insects, fish, rodents, lizards and amphibians as reservoirs for Mycobacterium ulcerans. Eighth Maastricht Medical Students Research Conference. Maastricht, The Netherlands: University of Maastricht.
-
22
Portaels F, Zinsou C, Aguiar J, Debacker M, de Biurrun E, Guédénon A, Josse R, Lagarrigue V, Silva MT, Steunou C, Meyers WM, 2003. Les atteintes osseuses dans l’ulcère de Buruli: à propos de 73 cas. Bull Seanc Acad R Sci Outre Mer 49 :161–190.
-
23
Debacker M, Aguiar J, Steunou C, Zinsou C, Meyers WM, Portaels F, 2005. Buruli ulcer recurrence, Benin. Emerg Infect Dis 11 :584–589.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 127 | 101 | 9 |
| Full Text Views | 253 | 4 | 1 |
| PDF Downloads | 65 | 4 | 1 |