ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Graves P, Gelband H, 2001.Vaccines for preventing malaria (Cochrane Review). The Cochrane Library 1. Oxford: Update Software.
-
2
Guiguemde TR, Sturchler D, Ouedraogo JB, Drabo M, Etlinger H, Douchet C, Gbary AR, Haller L, Kambou S, Fernex M, 1990. Vaccination against malaria: initial trial with an anti-sporozoite vaccine, (NANP)3-TT (RO 40-2361) in Africa (Bobo-Dioulasso, Burkina Faso). Bull Soc Pathol Exot 8 :217–227.
-
3
Reber-Liske R, Salako LA, Matile H, Sowunmi A, Sturchler D, 1995. NANP 19-5.1. A malaria vaccine field trial in Nigerian children. Trop Geogr Med 47 :61–63.
-
4
Sherwood JA, Copeland RS, Taylor KA, Abok K, Oloo AJ, Were JB, Strickland GT, Gordon DM, Ballou WR, Bales JD, Wirtz RA, Wittes J, Gross M, Que JU, Cryz SJ, Oster CN, Roberts CR, Sadoff JC, 1996. Plasmodium falciparum circum-sporozoite vaccine immunogenicity and efficacy trial with natural challenge quantitation in an area of endemic human malaria in Kenya. Vaccine 14 :817–827.
-
5
Stoute JA, Slaoui M, Heppner DG, Momin P, Kester KE, Desmons P, Wellde BT, Garcon N, Krzych U, Marchand M, and the RTS,S Malaria Vaccine Evaluation Group. 1997. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. N Engl J Med 336 :86–91.
-
6
Stoute JA, Kester KE, Krzych U, Wellde BT, Hall T, White K, Glenn G, Ockenhouse CF, Garcon N, Schwenk R, Lanar DE, Sun P, Momin P, Wirtz RA, Golenda C, Slaoui M, Wortmann G, Holland C, Dowler M, Cohen J, Ballou WR, 1998. Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine. J Infect Dis 178 :1139–1144.
-
7
Kester KE, McKinney DA, Tornieporth N, Ockenhouse CF, Heppner DG, Hall T, Krzych U, Delchambre M, Voss G, Dowler MG, Palensky J, Wittes J, Cohen J, Ballou WR, and the RTS,S Malaria Vaccine Evaluation Group, 2001. Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria. J Infect Dis 183: 640–647.
-
8
Lalvani A, Moris P, Voss G, Pathan AA, Kester KE, Brookes R, Lee E, Koutsoukos M, Plebanski M, Delchambre M, Flanagan KL, Carton C, Slaoui M, Van Hoecke C, Ballou WR, Hill AV, Cohen J, 1999. Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine. J Infect Dis 180 :1656–1664.
-
9
Bojang K, Milligan PJM, Pinder M, Vigneron L, Alloueche A, Kester KE, W. Ballou WR, Conway DJ, Reece WHH, Gothard P, Yamuah L, Delchambre M, Voss G, Greenwood BM, Hill A, McAdam KPWJ, Tornieporth N, Cohen JD, Doherty T, and the RTS,S malaria vaccine trial team, 2001. Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial. Lancet 358: 1927–1934
-
10
Beck HP, Felger I, Huber W, Steiger S, Smith T, Weiss N, Alonso P, Tanner M, 1997. Analysis of multiple Plasmodium falciparum infections in Tanzanian children during the phase III trial of the malaria vaccine SPf66. J Infect Dis 175 :921–926.
-
11
Haywood M, Conway DJ, Weiss H, Metzger W, D’Alessandro U, Snounou G, Targett G, Greenwood BM, 1999. Reduction in the mean number of Plasmodium falciparum genotypes in Gambian children immunized with the malaria vaccine SPf66. Trans R Soc Trop Med Hyg 93 :65–68.
-
12
Alloueche A, Silveira H, Conway DJ, Bojang K, Doherty T, Cohen J, Pinder M, Greenwood BM, 2000. High-throughput sequence typing of T-cell epitope polymorphisms in Plasmodium falciparum circumsporozoite protein. Mol Biochem Parasitol 106 :273–282.
-
13
Viriyakosol S, Siripoon N, Petcharapirat C, Petcharapirat P, Jarra W, Thaithong S, Brown KN, Snounou G, 1995. Genotyping of Plasmodium falciparum isolates by the polymerase chain reaction and potential uses in epidemiological studies. Bull World Health Organ 73 :85–95.
-
14
Cuzick J, 1985. A Wilcoxon-type test for trend. Stat Med 4 :87–90.
-
15
Cuzick J, 1985. A method for analysing case-control studies with ordinal exposure variables. Biometrics 41 :609–621.
-
16
Zavala F, Cochrane AH, Nardin EH, Nussenzweig RS, Nussenzweig V, 1983. Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes. J Exp Med 157 :1947–1957.
-
17
Herrington D, Davis J, Nardin E, Beier M, Cortese J, Eddy H, Losonsky G, Hollingdale M, Sztein M, Levine M, Nussenzweig RS, Clyde D, Edelman R, 1991. Successful immunization of humans with irradiated malaria sporozoites: humoral and cellular responses of the protected individuals. Am J Trop Med Hyg 45 :539–547.
-
18
Nardin EH, Nussenzweig RS, 1993. RS T cell responses to pre-erythrocytic stages of malaria: role in protection and vaccine development against pre-erythrocytic stages. Annu Rev Immunol 11 :687–727.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 836 | 777 | 56 |
| Full Text Views | 371 | 2 | 0 |
| PDF Downloads | 112 | 2 | 0 |
PROTECTIVE EFFICACY OF THE RTS,S/AS02 PLASMODIUM FALCIPARUM MALARIA VACCINE IS NOT STRAIN SPECIFIC
ALI ALLOUECHE
ALI ALLOUECHE
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Medical Research Council Laboratories, Fajara, The Gambia; GlaxoSmithKline Biologicals, Rixensart, Belgium
Search for other papers by ALI ALLOUECHE in
Current site
Google Scholar
PubMed
Search for other papers by ALI ALLOUECHE in
Current site
Google Scholar
PubMed
PAUL MILLIGAN
PAUL MILLIGAN
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Medical Research Council Laboratories, Fajara, The Gambia; GlaxoSmithKline Biologicals, Rixensart, Belgium
Search for other papers by PAUL MILLIGAN in
Current site
Google Scholar
PubMed
Search for other papers by PAUL MILLIGAN in
Current site
Google Scholar
PubMed
DAVID J. CONWAY
DAVID J. CONWAY
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Medical Research Council Laboratories, Fajara, The Gambia; GlaxoSmithKline Biologicals, Rixensart, Belgium
Search for other papers by DAVID J. CONWAY in
Current site
Google Scholar
PubMed
Search for other papers by DAVID J. CONWAY in
Current site
Google Scholar
PubMed
MARGARET PINDER
MARGARET PINDER
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Medical Research Council Laboratories, Fajara, The Gambia; GlaxoSmithKline Biologicals, Rixensart, Belgium
Search for other papers by MARGARET PINDER in
Current site
Google Scholar
PubMed
Search for other papers by MARGARET PINDER in
Current site
Google Scholar
PubMed
KALIFA BOJANG
KALIFA BOJANG
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Medical Research Council Laboratories, Fajara, The Gambia; GlaxoSmithKline Biologicals, Rixensart, Belgium
Search for other papers by KALIFA BOJANG in
Current site
Google Scholar
PubMed
Search for other papers by KALIFA BOJANG in
Current site
Google Scholar
PubMed
TOM DOHERTY
TOM DOHERTY
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Medical Research Council Laboratories, Fajara, The Gambia; GlaxoSmithKline Biologicals, Rixensart, Belgium
Search for other papers by TOM DOHERTY in
Current site
Google Scholar
PubMed
Search for other papers by TOM DOHERTY in
Current site
Google Scholar
PubMed
NADIA TORNIEPORTH
NADIA TORNIEPORTH
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Medical Research Council Laboratories, Fajara, The Gambia; GlaxoSmithKline Biologicals, Rixensart, Belgium
Search for other papers by NADIA TORNIEPORTH in
Current site
Google Scholar
PubMed
Search for other papers by NADIA TORNIEPORTH in
Current site
Google Scholar
PubMed
JOE COHEN
JOE COHEN
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Medical Research Council Laboratories, Fajara, The Gambia; GlaxoSmithKline Biologicals, Rixensart, Belgium
Search for other papers by JOE COHEN in
Current site
Google Scholar
PubMed
Search for other papers by JOE COHEN in
Current site
Google Scholar
PubMed
BRIAN M. GREENWOOD
BRIAN M. GREENWOOD
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Medical Research Council Laboratories, Fajara, The Gambia; GlaxoSmithKline Biologicals, Rixensart, Belgium
Search for other papers by BRIAN M. GREENWOOD in
Current site
Google Scholar
PubMed
Search for other papers by BRIAN M. GREENWOOD in
Current site
Google Scholar
PubMed
RTS,S/AS02 is a recombinant protein malaria vaccine that contains a large portion of the C-terminal of the circumsporozoite protein (CSP) sequence of the NF54 isolate of Plasmodium falciparum fused to the hepatitis B virus surface antigen. It has been shown to induce significant protection to challenge infection with a homologous parasite strain in American volunteers. In a recently completed trial in semi-immune Gambian adults, vaccine efficacy against natural infection was 34% (95% confidence interval = 8–53%, P = 0.014) during the malaria season following vaccination. Breakthrough P. falciparum parasites sampled from vaccinated subjects and from controls were genotyped at two polymorphic regions of the csp gene encoding T cell epitopes (csp-th2r and csp-th3r) to determine if the vaccine conferred a strain-specific effect. The overall distribution of csp allelic variants was similar in infections occurring in vaccine and control groups. Also, the mean number of genotypes per infection in the RTS,S/AS02 group was not reduced compared with the controls.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Graves P, Gelband H, 2001.Vaccines for preventing malaria (Cochrane Review). The Cochrane Library 1. Oxford: Update Software.
-
2
Guiguemde TR, Sturchler D, Ouedraogo JB, Drabo M, Etlinger H, Douchet C, Gbary AR, Haller L, Kambou S, Fernex M, 1990. Vaccination against malaria: initial trial with an anti-sporozoite vaccine, (NANP)3-TT (RO 40-2361) in Africa (Bobo-Dioulasso, Burkina Faso). Bull Soc Pathol Exot 8 :217–227.
-
3
Reber-Liske R, Salako LA, Matile H, Sowunmi A, Sturchler D, 1995. NANP 19-5.1. A malaria vaccine field trial in Nigerian children. Trop Geogr Med 47 :61–63.
-
4
Sherwood JA, Copeland RS, Taylor KA, Abok K, Oloo AJ, Were JB, Strickland GT, Gordon DM, Ballou WR, Bales JD, Wirtz RA, Wittes J, Gross M, Que JU, Cryz SJ, Oster CN, Roberts CR, Sadoff JC, 1996. Plasmodium falciparum circum-sporozoite vaccine immunogenicity and efficacy trial with natural challenge quantitation in an area of endemic human malaria in Kenya. Vaccine 14 :817–827.
-
5
Stoute JA, Slaoui M, Heppner DG, Momin P, Kester KE, Desmons P, Wellde BT, Garcon N, Krzych U, Marchand M, and the RTS,S Malaria Vaccine Evaluation Group. 1997. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. N Engl J Med 336 :86–91.
-
6
Stoute JA, Kester KE, Krzych U, Wellde BT, Hall T, White K, Glenn G, Ockenhouse CF, Garcon N, Schwenk R, Lanar DE, Sun P, Momin P, Wirtz RA, Golenda C, Slaoui M, Wortmann G, Holland C, Dowler M, Cohen J, Ballou WR, 1998. Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine. J Infect Dis 178 :1139–1144.
-
7
Kester KE, McKinney DA, Tornieporth N, Ockenhouse CF, Heppner DG, Hall T, Krzych U, Delchambre M, Voss G, Dowler MG, Palensky J, Wittes J, Cohen J, Ballou WR, and the RTS,S Malaria Vaccine Evaluation Group, 2001. Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria. J Infect Dis 183: 640–647.
-
8
Lalvani A, Moris P, Voss G, Pathan AA, Kester KE, Brookes R, Lee E, Koutsoukos M, Plebanski M, Delchambre M, Flanagan KL, Carton C, Slaoui M, Van Hoecke C, Ballou WR, Hill AV, Cohen J, 1999. Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine. J Infect Dis 180 :1656–1664.
-
9
Bojang K, Milligan PJM, Pinder M, Vigneron L, Alloueche A, Kester KE, W. Ballou WR, Conway DJ, Reece WHH, Gothard P, Yamuah L, Delchambre M, Voss G, Greenwood BM, Hill A, McAdam KPWJ, Tornieporth N, Cohen JD, Doherty T, and the RTS,S malaria vaccine trial team, 2001. Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial. Lancet 358: 1927–1934
-
10
Beck HP, Felger I, Huber W, Steiger S, Smith T, Weiss N, Alonso P, Tanner M, 1997. Analysis of multiple Plasmodium falciparum infections in Tanzanian children during the phase III trial of the malaria vaccine SPf66. J Infect Dis 175 :921–926.
-
11
Haywood M, Conway DJ, Weiss H, Metzger W, D’Alessandro U, Snounou G, Targett G, Greenwood BM, 1999. Reduction in the mean number of Plasmodium falciparum genotypes in Gambian children immunized with the malaria vaccine SPf66. Trans R Soc Trop Med Hyg 93 :65–68.
-
12
Alloueche A, Silveira H, Conway DJ, Bojang K, Doherty T, Cohen J, Pinder M, Greenwood BM, 2000. High-throughput sequence typing of T-cell epitope polymorphisms in Plasmodium falciparum circumsporozoite protein. Mol Biochem Parasitol 106 :273–282.
-
13
Viriyakosol S, Siripoon N, Petcharapirat C, Petcharapirat P, Jarra W, Thaithong S, Brown KN, Snounou G, 1995. Genotyping of Plasmodium falciparum isolates by the polymerase chain reaction and potential uses in epidemiological studies. Bull World Health Organ 73 :85–95.
-
14
Cuzick J, 1985. A Wilcoxon-type test for trend. Stat Med 4 :87–90.
-
15
Cuzick J, 1985. A method for analysing case-control studies with ordinal exposure variables. Biometrics 41 :609–621.
-
16
Zavala F, Cochrane AH, Nardin EH, Nussenzweig RS, Nussenzweig V, 1983. Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes. J Exp Med 157 :1947–1957.
-
17
Herrington D, Davis J, Nardin E, Beier M, Cortese J, Eddy H, Losonsky G, Hollingdale M, Sztein M, Levine M, Nussenzweig RS, Clyde D, Edelman R, 1991. Successful immunization of humans with irradiated malaria sporozoites: humoral and cellular responses of the protected individuals. Am J Trop Med Hyg 45 :539–547.
-
18
Nardin EH, Nussenzweig RS, 1993. RS T cell responses to pre-erythrocytic stages of malaria: role in protection and vaccine development against pre-erythrocytic stages. Annu Rev Immunol 11 :687–727.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 836 | 777 | 56 |
| Full Text Views | 371 | 2 | 0 |
| PDF Downloads | 112 | 2 | 0 |