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A Comparative Trial of a Single-Dose Ivermectin Versus Three Days of Albendazole for Treatment of Strongyloides Stercoralis and Other Soil-Transmitted Helminth Infections in Children
Hanspeter Marti
Hanspeter Marti
Swiss Tropical Institute, Ifakara Centre, Schistosomiasis and Intestinal Parasites Unit, Division of Control of Tropical Diseases, World Health Organization, Ministry of Health, Basel, Switzerland
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Hamad J. Haji
Hamad J. Haji
Swiss Tropical Institute, Ifakara Centre, Schistosomiasis and Intestinal Parasites Unit, Division of Control of Tropical Diseases, World Health Organization, Ministry of Health, Basel, Switzerland
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Lorenzo Savioli
Lorenzo Savioli
Swiss Tropical Institute, Ifakara Centre, Schistosomiasis and Intestinal Parasites Unit, Division of Control of Tropical Diseases, World Health Organization, Ministry of Health, Basel, Switzerland
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Hababu Mohammed Chwaya
Hababu Mohammed Chwaya
Swiss Tropical Institute, Ifakara Centre, Schistosomiasis and Intestinal Parasites Unit, Division of Control of Tropical Diseases, World Health Organization, Ministry of Health, Basel, Switzerland
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Ali Foum Mgeni
Ali Foum Mgeni
Swiss Tropical Institute, Ifakara Centre, Schistosomiasis and Intestinal Parasites Unit, Division of Control of Tropical Diseases, World Health Organization, Ministry of Health, Basel, Switzerland
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Juma Suleiman Ameir
Juma Suleiman Ameir
Swiss Tropical Institute, Ifakara Centre, Schistosomiasis and Intestinal Parasites Unit, Division of Control of Tropical Diseases, World Health Organization, Ministry of Health, Basel, Switzerland
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Christoph Hatz
Christoph Hatz
Swiss Tropical Institute, Ifakara Centre, Schistosomiasis and Intestinal Parasites Unit, Division of Control of Tropical Diseases, World Health Organization, Ministry of Health, Basel, Switzerland
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A randomized trial carried out in rural Zanzibar comparing a single dose of 200 µg/kg of ivermectin and 400 mg/day for three days of albendazole for treatment of strongyloidiasis and other intestinal nematodes is described. In 301 children with Strongyloides stercoralis infection, treatment with ivermectin or albendazole resulted in cure rates of 83% and 45%, respectively. While both drugs were very effective against Ascaris lumbricoides, Trichuris trichiura was cured only in 11% (ivermectin) and 43% (albendazole) of the subjects, although the mean eggload was reduced by 59% and 92%, respectively. Ivermectin was ineffective against hookworms, while albendazole resulted in a cure rate of 98%. No severe side effects were recorded and mild side effects were of transient nature for both treatments. Therefore, ivermectin provides a safe and highly effective single dose treatment for S. stercoralis and A. lumbricoides, while it is not an alternative for the treatment of T. trichiura and hookworm infections.
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| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 3726 | 415 | 34 |
| Full Text Views | 103 | 11 | 0 |
| PDF Downloads | 132 | 22 | 0 |