Filariasis Testing in a Jird Model: New Drug Leads from Some Old Standbys

Kenneth E. Kinnamon Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Department of Parasitology, College of Veterinary Medicine, University of Georgia, Washington, District of Columbia, Georgia

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Daniel L. Klayman Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Department of Parasitology, College of Veterinary Medicine, University of Georgia, Washington, District of Columbia, Georgia

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Bing T. Poon Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Department of Parasitology, College of Veterinary Medicine, University of Georgia, Washington, District of Columbia, Georgia

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John W. McCall Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Department of Parasitology, College of Veterinary Medicine, University of Georgia, Washington, District of Columbia, Georgia

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Michael T. Dzimianski Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Department of Parasitology, College of Veterinary Medicine, University of Georgia, Washington, District of Columbia, Georgia

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Samuel J. Rowan Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Department of Parasitology, College of Veterinary Medicine, University of Georgia, Washington, District of Columbia, Georgia

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DOI:
https://doi.org/10.4269/ajtmh.1994.51.791
Volume/Issue:
Volume 51: Issue 6
Page(s):
791–796
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A total of 65 compounds, most of which were from chemical classes having members known to be active against one or more parasitic organisms, were evaluated against Brugia pahangi and Acanthocheilonema viteae for macrofilaricidal activity in male Mongolian jirds (Meriones unguiculatus). Sixteen of the 65 compounds tested suppressed the number of parasites. Of these 16, three were suppressive for B. pahangi, 10 for A. viteae, and three for both parasites. The antibiotic nigericin and the antihistaminic isothipendyl were found to be most active.

Author Notes

Deceased.

Copyright:
Copyright © 1994 by The American Society of Tropical Medicine and Hygiene 1994
Published Online:
Dec 1994
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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