A Longitudinal Study of Junin Virus Activity in the Rodent Reservoir of Agrentine Hemorrhagic Fever

James N. Mills Department of Immunology and Infectious Diseases, The Johns Hopkins University School of Hygiene and Public Health, U.S. Army Medical Research Institute of Infectious Diseases, Instituto Nacional de Estudios Sobre Virosis Hemorragicas, Pergamino, Provincia de Buenos Aires, Baltimore, Maryland, Argentina

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Barbara A. Ellis Department of Immunology and Infectious Diseases, The Johns Hopkins University School of Hygiene and Public Health, U.S. Army Medical Research Institute of Infectious Diseases, Instituto Nacional de Estudios Sobre Virosis Hemorragicas, Pergamino, Provincia de Buenos Aires, Baltimore, Maryland, Argentina

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Kelly T. McKee Jr Department of Immunology and Infectious Diseases, The Johns Hopkins University School of Hygiene and Public Health, U.S. Army Medical Research Institute of Infectious Diseases, Instituto Nacional de Estudios Sobre Virosis Hemorragicas, Pergamino, Provincia de Buenos Aires, Baltimore, Maryland, Argentina

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Gladys E. Calderon Department of Immunology and Infectious Diseases, The Johns Hopkins University School of Hygiene and Public Health, U.S. Army Medical Research Institute of Infectious Diseases, Instituto Nacional de Estudios Sobre Virosis Hemorragicas, Pergamino, Provincia de Buenos Aires, Baltimore, Maryland, Argentina

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Julio I. Maiztegui Department of Immunology and Infectious Diseases, The Johns Hopkins University School of Hygiene and Public Health, U.S. Army Medical Research Institute of Infectious Diseases, Instituto Nacional de Estudios Sobre Virosis Hemorragicas, Pergamino, Provincia de Buenos Aires, Baltimore, Maryland, Argentina

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Gene O. Nelson Department of Immunology and Infectious Diseases, The Johns Hopkins University School of Hygiene and Public Health, U.S. Army Medical Research Institute of Infectious Diseases, Instituto Nacional de Estudios Sobre Virosis Hemorragicas, Pergamino, Provincia de Buenos Aires, Baltimore, Maryland, Argentina

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Thomas G. Ksiazek Department of Immunology and Infectious Diseases, The Johns Hopkins University School of Hygiene and Public Health, U.S. Army Medical Research Institute of Infectious Diseases, Instituto Nacional de Estudios Sobre Virosis Hemorragicas, Pergamino, Provincia de Buenos Aires, Baltimore, Maryland, Argentina

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Clarence J. Peters Department of Immunology and Infectious Diseases, The Johns Hopkins University School of Hygiene and Public Health, U.S. Army Medical Research Institute of Infectious Diseases, Instituto Nacional de Estudios Sobre Virosis Hemorragicas, Pergamino, Provincia de Buenos Aires, Baltimore, Maryland, Argentina

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James E. Childs Department of Immunology and Infectious Diseases, The Johns Hopkins University School of Hygiene and Public Health, U.S. Army Medical Research Institute of Infectious Diseases, Instituto Nacional de Estudios Sobre Virosis Hemorragicas, Pergamino, Provincia de Buenos Aires, Baltimore, Maryland, Argentina

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DOI:
https://doi.org/10.4269/ajtmh.1992.47.749
Volume/Issue:
Volume 47: Issue 6
Page(s):
749–763
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We monitored Junin virus (JV) activity in rodent populations for 30 months at seven mark-recapture grids located in agricultural fields and adjacent roadsides and fence lines in endemic and nonendemic areas of Argentine hemorrhagic fever. Blood and oral swabs taken from rodents captured at five-week intervals were analyzed by enzyme-linked immunosorbent assay for JV antigen (Ag). Calomys laucha and C. musculinus were the most frequently captured rodents, making up 47% and 22% of captures, respectively. Of 41 Ag-positive captures, 37 were C. musculinus and four were C. laucha; 34 were from two trapping grids in the same locality. Antigen-positive Calomys were more frequently male (76%), and were found significantly more frequently among the oldest animals and the largest body mass classes. These patterns, combined with the greater mobility and higher frequencies of wounds among males than females, implicated horizontal transmission as the primary route of JV transmission between rodents. Seasonal maximum levels in JV prevalence (up to 25% of captured Ag-positive C. musculinus) occurred during periods of maximal population densities of Calomys. Spatial distribution of Ag-positive rodents reflected habitat preferences; most Ag-positive C. musculinus were captured from border habitats (roadsides and fence lines), and all Ag-positive C. laucha were captured in crop fields. These distinct, but previously undocumented, habitat preferences suggest that the disease in humans may be related to exposures to the primary reservoir species, C. musculinus, in border habitats rather than in crop fields.

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Copyright:
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene 1992
Published Online:
Dec 1992
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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