Albendazole in the Treatment of Onchocerciasis: Double-Blind Clinical Trial in Venezuela

Barnett L. Cline Departments of Tropical Medicine, and Biostatistics and Epidemiology, School of Public Health and Tropical Medicine, Tulane University Medical Center, Ministry of Health, Central University Hospital Dr. Manuel Nunez Tovar, Instituto de Biomedicina, New Orleans, Louisiana, Venezuela

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Jesus Luque Hernandez Departments of Tropical Medicine, and Biostatistics and Epidemiology, School of Public Health and Tropical Medicine, Tulane University Medical Center, Ministry of Health, Central University Hospital Dr. Manuel Nunez Tovar, Instituto de Biomedicina, New Orleans, Louisiana, Venezuela

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Frances J. Mather Departments of Tropical Medicine, and Biostatistics and Epidemiology, School of Public Health and Tropical Medicine, Tulane University Medical Center, Ministry of Health, Central University Hospital Dr. Manuel Nunez Tovar, Instituto de Biomedicina, New Orleans, Louisiana, Venezuela

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Richard Bartholomew Departments of Tropical Medicine, and Biostatistics and Epidemiology, School of Public Health and Tropical Medicine, Tulane University Medical Center, Ministry of Health, Central University Hospital Dr. Manuel Nunez Tovar, Instituto de Biomedicina, New Orleans, Louisiana, Venezuela

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Sonia Nunez De Maza Departments of Tropical Medicine, and Biostatistics and Epidemiology, School of Public Health and Tropical Medicine, Tulane University Medical Center, Ministry of Health, Central University Hospital Dr. Manuel Nunez Tovar, Instituto de Biomedicina, New Orleans, Louisiana, Venezuela

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Sara Rodulfo Departments of Tropical Medicine, and Biostatistics and Epidemiology, School of Public Health and Tropical Medicine, Tulane University Medical Center, Ministry of Health, Central University Hospital Dr. Manuel Nunez Tovar, Instituto de Biomedicina, New Orleans, Louisiana, Venezuela

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Charles A. Welborn Departments of Tropical Medicine, and Biostatistics and Epidemiology, School of Public Health and Tropical Medicine, Tulane University Medical Center, Ministry of Health, Central University Hospital Dr. Manuel Nunez Tovar, Instituto de Biomedicina, New Orleans, Louisiana, Venezuela

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Mark L. Eberhard Departments of Tropical Medicine, and Biostatistics and Epidemiology, School of Public Health and Tropical Medicine, Tulane University Medical Center, Ministry of Health, Central University Hospital Dr. Manuel Nunez Tovar, Instituto de Biomedicina, New Orleans, Louisiana, Venezuela

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Jacinto Convit Departments of Tropical Medicine, and Biostatistics and Epidemiology, School of Public Health and Tropical Medicine, Tulane University Medical Center, Ministry of Health, Central University Hospital Dr. Manuel Nunez Tovar, Instituto de Biomedicina, New Orleans, Louisiana, Venezuela

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DOI:
https://doi.org/10.4269/ajtmh.1992.47.512
Volume/Issue:
Volume 47: Issue 4
Page(s):
512–520
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A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection. Forty-nine patients (26 treated and 23 controls) received a 10-day course of albendazole (400 mg/day) or a placebo. Consistent with the excellent tolerance observed, albendazole did not kill microfilariae. However, analysis of changes in microfilarial densities (mf/mg of skin) over one year showed that albendazole was active against O. volvulus, presumably by interfering with embryogenesis. The nature, degree, and duration of this effect remain to be determined.

Author Notes

Copyright:
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene 1992
Published Online:
Oct 1992
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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