Sulfadoxine-Pyrimethamine for the Treatment of Acute Malaria in Children in Papua New Guinea

II. Plasmodium vivax

Brian Darlow Papua New Guinea Institute of Medical Research, Madang General Hospital, P.O. Box 378, Madang, Papua New Guinea

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Helena Vrbova Papua New Guinea Institute of Medical Research, Madang General Hospital, P.O. Box 378, Madang, Papua New Guinea

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Sean Gibney Papua New Guinea Institute of Medical Research, Madang General Hospital, P.O. Box 378, Madang, Papua New Guinea

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Damien Jolley Papua New Guinea Institute of Medical Research, Madang General Hospital, P.O. Box 378, Madang, Papua New Guinea

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John Stace Papua New Guinea Institute of Medical Research, Madang General Hospital, P.O. Box 378, Madang, Papua New Guinea

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Michael Alpers Papua New Guinea Institute of Medical Research, Madang General Hospital, P.O. Box 378, Madang, Papua New Guinea

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DOI:
https://doi.org/10.4269/ajtmh.1982.31.10
Volume/Issue:
Volume 31: Issue 1
Page(s):
10–13
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In Papua New Guinea, Plasmodium falciparum and P. vivax are common causes of acute malaria in children and P. malariae an uncommon cause. The increasing prevelance of chloroquine-resistant strains of P. falciparum in Papua New Guinea has prompted the search for alternatives to chloroquine as standard presumptive treatment. Sulfadoxine-pyrimethamine, either alone or in combination with a single dose of chloroquine, was compared with chloroquine alone for treatment of acute vivax malaria in children in Madang. Fever resolution was slowest in the group treated with sulfadoxine-pyrimethamine alone, and time to clearance of parasitemia was significantly longer in this group (P < 0.001). Where possible, species identification should be undertaken in acute malaria and cases of P. vivax treated with chloroquine.

Author Notes

Present address: Department of Paediatrics, Christchurch Hospital, Private Bag, Christchurch, New Zealand.

Copyright:
Copyright © 1982 by The American Society of Tropical Medicine and Hygiene 1982
Accepted:
28 Mar 1981
|
Published Online:
Jan 1982
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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