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Correlation between Circulating Antigens Detected by the Radioimmunoprecipitation-Polyethylene Glycol Assay (Ripega) and C1q-Binding Immune Complexes in Human Schistosomiasis Mansoni
Ferrucio Santoro
Ferrucio Santoro
Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur de Lille, Faculdade de Ciências da Saúde, Universidade de Brasilia, 59019 Lille Cedex, France
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Aluizio Prata
Aluizio Prata
Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur de Lille, Faculdade de Ciências da Saúde, Universidade de Brasilia, 59019 Lille Cedex, France
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Antônio E. Silva
Antônio E. Silva
Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur de Lille, Faculdade de Ciências da Saúde, Universidade de Brasilia, 59019 Lille Cedex, France
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André Capron
André Capron
Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur de Lille, Faculdade de Ciências da Saúde, Universidade de Brasilia, 59019 Lille Cedex, France
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Circulating schistosome antigens (CSA) and circulating immune complexes (CIC) were investigated in serum from 420 patients infected with Schistosoma mansoni. The radioimmunoprecipitation-polyethylene glycol assay with [125I] anti-S. mansoni rabbit antibodies appeared as a sensitive and specific method to quantify CSA. In fact, more than 75% of the patients showed significant levels of CSA. C1q-binding CIC were also detected in 70% of subjects with schistosomiasis. In addition, a close correlation was observed between levels of CSA and CIC. These data suggest that part of the CIC present in human schistosomiasis are formed by schistosome specific antigens.
Author Notes
Present address: Department of Pathology, New York University Medical Center, New York, New York 10016.
| Past two years | Past Year | Past 30 Days | |
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