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Venezuelan Equine Encephalitis Virus: Comparison of Infectivity and Virulence of Strains V-38 and P676 in Donkeys
R. M. Mackenzie
R. M. Mackenzie
Instituto de Investigaciones Veterinarias, Apartado 70, Maracay, Venezuela
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J. de Siger
J. de Siger
Instituto de Investigaciones Veterinarias, Apartado 70, Maracay, Venezuela
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D. V. Parra
D. V. Parra
Instituto de Investigaciones Veterinarias, Apartado 70, Maracay, Venezuela
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Two strains of Venezuelan equine encephalitis (VEE) virus were examined for the ability to replicate in, as well as to produce death among donkeys. One, a low passage strain known as strain P676, was originally isolated from mosquitos in Venezuela. The other, strain V-38, was isolated from a horse brain in 1938 and had undergone an unknown number of laboratory passages; it is used extensively for the preparation of inactivated VEE vaccine. Both strains were found to be approximately equal in their ability to infect donkeys. However, a quantity as small as 50% hamster intraperitoneal infectious units of strain V-38 resulted in fatal infection. On the other hand, as much as 631 million infectious units of strain P676 were nonfatal in one of two donkeys. It appears that strain V-38 is approximately 100 million times more virulent than strain P676 in equine species. One donkey which received strain P676 demonstrated a biphasic pattern of clinical illness and viremia, and there is suggestive evidence that another animal experienced a second and fatal clinical response 3 weeks after virus inoculation.
Author Notes
Present address: 330 The Village, No. 306, Redondo Beach, California 90277.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 417 | 163 | 18 |
| Full Text Views | 6 | 3 | 0 |
| PDF Downloads | 7 | 5 | 0 |