| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 526 | 193 | 35 |
| Full Text Views | 5 | 1 | 0 |
| PDF Downloads | 5 | 2 | 0 |
Minocycline and Tetracycline Treatment of Acute Falciparum Malaria in Thailand
Edward J. Colwell
Edward J. Colwell
U. S. Army Medical Component, SEATO, Prapokkloa Hospital, APO San Francisco 96346, Thailand
Search for other papers by Edward J. Colwell in
Current site
Google Scholar
PubMed
Search for other papers by Edward J. Colwell in
Current site
Google Scholar
PubMed
Robert L. Hickman
Robert L. Hickman
U. S. Army Medical Component, SEATO, Prapokkloa Hospital, APO San Francisco 96346, Thailand
Search for other papers by Robert L. Hickman in
Current site
Google Scholar
PubMed
Search for other papers by Robert L. Hickman in
Current site
Google Scholar
PubMed
Ravivan Intraprasert
Ravivan Intraprasert
U. S. Army Medical Component, SEATO, Prapokkloa Hospital, APO San Francisco 96346, Thailand
Search for other papers by Ravivan Intraprasert in
Current site
Google Scholar
PubMed
Search for other papers by Ravivan Intraprasert in
Current site
Google Scholar
PubMed
Chalard Tirabutana
Chalard Tirabutana
U. S. Army Medical Component, SEATO, Prapokkloa Hospital, APO San Francisco 96346, Thailand
Search for other papers by Chalard Tirabutana in
Current site
Google Scholar
PubMed
Search for other papers by Chalard Tirabutana in
Current site
Google Scholar
PubMed
The purpose of this study was to evalute the antimalarial action of a new tetracycline analogue, minocycline, which is more potent and has a broader antibacterial spectrum than tetracycline. The study was conducted in an area endemic for chloroquine-resistant falciparum malaria. Acutely ill residents infected with P. falciparum were alternately assigned to one of two treatment groups. Subjects in one group were given 540 mg of quinine base, thrice daily for 3 days followed by 100 mg of minocycline, twice daily for 7 days. Subjects in the other group were given a similar course of quinine followed by 250 mg of tetracycline, 4 times daily for 10 days. Presumptive radical cures were achieved in all 29 patients treated with quinine-tetracycline and in 27 of 28 treated with quinine-minocycline. No significant toxic side-effects were observed. Although both treatments were highly effective, further studies are warranted to determine the optimal duration and dosage of minocycline and its potential human toxicity.
Author Notes
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 526 | 193 | 35 |
| Full Text Views | 5 | 1 | 0 |
| PDF Downloads | 5 | 2 | 0 |