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Plasmodium Vivax Malaria and Coombs-Positive Anemia
Elizabeth Barrett-Connor
Elizabeth Barrett-Connor
Division of Infectious Diseases, Department of Medicine, University of Miami School of Medicine and Jackson Memorial Hospital, Miami, Florida
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Summary
A case of low-grade Plasmodium vivax parasitemia and severe anemia associated with the serologic stigmata of autoimmune disease, a positive Coombs test, positive serologic test for syphilis, positive rheumatoid factor, and slight elevation of the serum gamma globulin fraction is described. Coombs-positive hemolysis has not been previously reported in untreated malaria. The possible significance of the Coombs test and the mechanism of anemia in malaria are discussed.
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