Article Category:
Short Report

Seroprevalence of Dengue Infection Using IgG Capture ELISA in India, 2017–2018

Muthusamy Santhosh Kumar Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India;

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P. Kamaraj Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India;

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Siraj Ahmed Khan ICMR-Regional Medical Research Centre, Northeast Region, Dibrugarh, India;

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Ramesh Reddy Allam Science Health Allied Research Education India, Hyderabad, India;

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Pradip V. Barde ICMR-National Institute of Research in Tribal Health, Jabalpur, India;

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Bhagirathi Dwibedi ICMR-Regional Medical Research Centre, Bhubaneswar, India;

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Suman Kanungo ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India;

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Uday Mohan King George’s Medical University, Lucknow, India;

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Suman Sundar Mohanty ICMR, National Institute for Implementation Research on Non-Communicable Diseases, Jodhpur, India;

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Subarna Roy ICMR-National Institute of Traditional Medicine, Belagavi, India;

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Vivek Sagar Postgraduate Institute of Medical Education and Research, Chandigarh, India;

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Deepali Savargaonkar ICMR-National Institute of Malaria Research, New Delhi, India;

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Babasaheb V. Tandale ICMR-National Institute of Virology, Pune, India;

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Roshan Kamal Topno ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India

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C. P. Girish Kumar Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India;

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R. Sabarinathan Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India;

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V. Saravana Kumar Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India;

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T. Karunakaran Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India;

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Annamma Jose Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India;

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Provash Sadhukhan ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India;

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G. S. Toteja ICMR, National Institute for Implementation Research on Non-Communicable Diseases, Jodhpur, India;

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Shanta Dutta ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India;

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Manoj Murhekar Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India;

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DOI:
https://doi.org/10.4269/ajtmh.21-0386
Volume/Issue:
Volume 105: Issue 5
Page(s):
1277–1280
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ABSTRACT.

We conducted a nationally representative population-based survey in 60 districts from 15 Indian states covering all five geographic regions during 2017–2018 to estimate the age specific seroprevalence of dengue. Of the 12,300 sera collected, 4,955 were positive for IgG antibodies against dengue virus using IgG Indirect ELISA indicating past dengue infection. We tested 4,948 sera (seven had inadequate volume) positive for IgG antibodies on indirect ELISA using anti-dengue IgG capture ELISA to estimate the proportion of dengue infections with high antibody titers, suggestive of acute or recent secondary infection. Of the 4,948 sera tested, 529 (10.7%; 95% CI: 9.4–12.1) were seropositive on IgG capture ELISA. The proportions of dengue infections with high titers were 1.1% in the northeastern, 1.5% in the eastern, 6.2% in the western, 12.2% in the southern, and 16.7% in the northern region. The distribution of dengue infections varied across geographic regions, with a higher proportion of infections with high antibody titer in the northern and southern regions of India. The study findings could be useful for planning facilities for clinical management of dengue infections.

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Author Notes

*Address correspondence to Manoj Murhekar, ICMR-National Institute of Epidemiology, R127, TNHB, Ayapakkam, Chennai-600077, India. E-mail: mmurhekar@nieicmr.org.in

These authors contributed equally to this work.

Financial support: This study was funded by Indian Council of Medical Research, New Delhi

Authors’ addresses: Muthusamy Santhosh Kumar, P. Kamaraj, C. P. Girish Kumar, R. Sabarinathan, V. Saravana Kumar, T. Karunakaran, Annamma Jose, and Manoj Murhekar, ICMR-National Institute of Epidemiology, Chennai, India, E-mails: drsanthosmph09@gmail.com, pkrajreddy@gmail.com, girishmicro@gmail.com, sabari@nieicmr.org.in, saravanan.biostat1985@gmail.com, thiyakaruna@gmail.com, and aanjose.9@gmail.com. Siraj Ahmed Khan, ICMR-Regional Medical Research Centre, Northeast Region, Dibrugarh, India, E-mail: sirajkhanicmr@gmail.com. Ramesh Reddy Allam, Science Health Allied Research Education India, Hyderabad, India, E-mail: rameshallam@sharefoundations.org. Pradip V. Barde, ICMR-National Institute of Research in Tribal Health, Jabalpur, India, E-mail: pradip_barde@hotmail.com. Bhagirathi Dwibedi, ICMR-Regional Medical Research Centre, Bhubaneswar, India, E-mail: bhagirathidwibedi@yahoo.com. Suman Kanungo, Provash Sadhukhan, and Shanta Dutta, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India, E-mails: sumankanungo@gmail.com, provash2000@gmail.com, and shanta1232001@gmail.com. Uday Mohan, King George’s Medical University, Lucknow, India, E-mail: drudaymohan@yahoo.co.in. Suman Sundar Mohanty and G. S. Toteja, ICMR, National Institute for Implementation Research on Non-Communicable Diseases, Jodhpur, India, E-mails: ssnimr@gmail.com and gstoteja@gmail.com. Subarna Roy, ICMR-National Institute of Traditional Medicine, Belagavi, India, E-mail: drsubarnaroy@gmail.com. Vivek Sagar, Postgraduate Institute of Medical Education and Research, Chandigarh, India, E-mail: vivekgenetics@gmail.com. Deepali Savargaonkar, ICMR-National Institute of Malaria Research, New Delhi, India, E-mail: dr.deepali27@gmail.com. Babasaheb V. Tandale, ICMR-National Institute of Virology, Pune, India, E-mail: drtandale@gmail.com. Roshan Kamal Topno, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India, E-mail: roshanktopno@yahoo.co.in.

Copyright:
© The American Society of Tropical Medicine and Hygiene 2021
Received:
07 Apr 2021
|
Accepted:
20 Jun 2021
|
Published Online:
09 Aug 2021
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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