ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Yu XJ , 2011. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364: 1523–1532.
-
2.
Deng B , Zhou B , Zhang S , Zhu Y , Han L , Geng Y , Jin Z , Liu H , Wang D , Zhao Y , 2013. Clinical features and factors associated with severity and fatality among patients with severe fever with thrombocytopenia syndrome bunyavirus infection in northeast China. PLoS One 8: e80802.
-
3.
Ding YP , Liang MF , Ye J , Liu Q , Xiong C , Long B , Lin W , Cui N , Zou Z , Song Y , 2014. Prognostic value of clinical and immunological markers in acute phase of SFTS virus infection. Clin Microbiol Infect 20: O870–O878.
-
4.
Gai Z , Liang M , Zhang Y , Zhang S , Jin C , Wang SW , Sun L , Zhou N , Zhang Q , Sun Y , 2012. Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact. Clin Infect Dis 54: 249–252.
-
5.
Liu MM , Lei XY , Yu XJ , 2016. Meta-analysis of the clinical and laboratory parameters of SFTS patients in China. Virol J 13: 1–6.
-
6.
Sun J , Lu L , Wu H , Yang J , Liu K , Liu Q , 2018. Spatiotemporal patterns of severe fever with thrombocytopenia syndrome in China, 2011–2016. Ticks Tick Borne Dis 9: 927–933.
-
7.
Kim KH et al.2013. Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis 19: 1892–1894.
-
8.
Takahashi T et al., 2014. The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan. J Infect Dis 209: 816–827.
-
9.
Tran XC , Yun Y , Le Van An SHK , Thao NTP , Man PKC , Yoo JR , Heo ST , Cho N-H , Lee KH , 2019. Endemic severe fever with thrombocytopenia syndrome, Vietnam. Emerg Infect Dis 25: 1029.
-
10.
McMullan LK et al., 2012. A new phlebovirus associated with severe febrile illness in Missouri. N Engl J Med 367: 834–841.
-
11.
Kohl C , Brinkmann A , Radonic A , Dabrowski PW , Nitsche A , Muhldorfer K , Wibbelt G , Kurth A , 2020. Zwiesel bat banyangvirus, a potentially zoonotic Huaiyangshan banyangvirus (formerly known as SFTS)-like banyangvirus in northern bats from Germany. Sci Rep 10: 1370.
-
12.
Luo LM , Zhao L , Wen HL , Zhang ZT , Liu JW , Fang LZ , Xue ZF , Ma DQ , Zhang XS , Ding SJ , 2015. Haemaphysalis longicornis ticks as reservoir and vector of severe fever with thrombocytopenia syndrome virus in China. Emerg Infect Dis 21: 1770.
-
13.
Tang X et al., 2013. Human-to-human transmission of severe fever with thrombocytopenia syndrome bunyavirus through contact with infectious blood. J Infect Dis 207: 736–739.
-
14.
Liu JW et al., 2014. Prevalence of SFTSV among Asian house shrews and rodents, China, January–August 2013. Emerg Infect Dis 20: 2126–2128.
-
15.
Niu G , Li J , Liang M , Jiang X , Jiang M , Yin H , Wang Z , Li C , Zhang Q , Jin C , 2013. Severe fever with thrombocytopenia syndrome virus among domesticated animals, China. Emerg Infect Dis 19: 756.
-
16.
Huang XY , Du YH , Wang HF , You AG , Li Y , Su J , Nie YF , Ma HX , Xu BL , 2019. Prevalence of severe fever with thrombocytopenia syndrome virus in animals in Henan Province, China. Infect Dis Poverty 8: 56.
-
17.
Kida K et al., 2019. A case of cat-to-human transmission of severe fever with thrombocytopenia syndrome virus. Jpn J Infect Dis 72: 356–358.
-
18.
Liu Y , Li Q , Hu W , Wu J , Wang Y , Mei L , Walker DH , Ren J , Wang Y , Yu XJ , 2012. Person-to-person transmission of severe fever with thrombocytopenia syndrome virus. Vector Borne Zoonotic Dis 12: 156–160.
-
19.
Chen H , Hu K , Zou J , Xiao J , 2013. A cluster of cases of human-to-human transmission caused by severe fever with thrombocytopenia syndrome bunyavirus. Int J Infect Dis 17: e206–e208.
-
20.
Jiang XL et al., 2015. A cluster of person-to-person transmission cases caused by SFTS virus in Penglai, China. Clin Microbiol Infect 21: 274–279.
-
21.
Wang S , Li J , Niu G , Wang X , Ding S , Jiang X , Li C , Zhang Q , Liang M , Bi Z , 2015. SFTS virus in ticks in an endemic area of China. Am J Trop Med Hyg 92: 684–689.
-
22.
Gong Z , Gu S , Zhang Y , Sun J , Wu X , Ling F , Shi W , Zhang P , Li D , Mao H , 2015. Probable aerosol transmission of severe fever with thrombocytopenia syndrome virus in southeastern China. Clin Microbiol Infect 21: 1115–1120.
-
23.
Moon J et al., 2018. Aerosol transmission of severe fever with thrombocytopenia syndrome virus during resuscitation. Infect Control Hosp Epidemiol 40: 238–241.
-
24.
Zhan J , Wang Q , Cheng J , Hu B , Li J , Zhan F , Song Y , Guo D , 2017. Current status of severe fever with thrombocytopenia syndrome in China. Virol Sin 32: 51–62.
-
25.
Sun J , Tang Y , Ling F , Chang Y , Ye X , Shi W , Zhang L , Chen Z , Lin H , Qiu Z , 2015. Genetic susceptibility is one of the determinants for severe fever with thrombocytopenia syndrome virus infection and fatal outcome: an epidemiological investigation. PLoS One 10: e0132968.
-
26.
Sun J et al., 2014. Epidemiological characteristics of severe fever with thrombocytopenia syndrome in Zhejiang Province, China. Int J Infect Dis 25: 180–185.
-
27.
Sun J et al., 2016. Factors associated with severe fever with thrombocytopenia syndrome infection and fatal outcome. Sci Rep 6: 33175.
-
28.
Lin G , 2013. From “dying without a burial place” to “resting in peace”: research on the reform of Chinese funeral service system under the four-dimensional visual threshold. J Zhejiang Univ Humanit Soc Sci 3: 1–2.
-
29.
Ming W , 2012. The immortal of trailbreaker: the image and character of Fangxiang in ancient Chinese funeral ritual. J Tsinghua Univ Soc Sci 2: 116–125.
-
30.
Kun Q , 2014. Sonic expressions of cosmological awareness: a comparative study of funeral rituals among Han Chinese living in the Yangzi River Valley. Yearb Tradit Music 46: 159–169.
-
31.
Chan CLW , Chow AYM , Ho SMY , Tsui YKY , Tin AF , Koo BWK , Koo EWK , 2005. The experience of Chinese bereaved persons: a preliminary study of meaning making and continuing bonds. Death Stud 29: 923–947.
-
32.
National Health Commission of the People’s Republic of China , 2011. Points for Prevention and Control of Spread of Severe Syndrome with Thrombocytopenia by Contact. Available at: http://www.nhc.gov.cn/zwgk/wtwj/201304/447234f04fb54e38b91a2b1b900aa27d.shtml. Accessed August 12, 2011.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1237 | 378 | 19 |
| Full Text Views | 396 | 36 | 1 |
| PDF Downloads | 185 | 20 | 1 |
Characteristics of Three Person-to-Person Transmission Clusters of Severe Fever with Thrombocytopenia Syndrome in Southeastern China
Mingyong Tao
Mingyong Tao
Ningbo University, Ningbo, China;
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Ying Liu
Ying Liu
Key Laboratory of Vaccine, Prevention and Control of Infectious Disease of Zhejiang Province, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
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Feng Ling
Feng Ling
Key Laboratory of Vaccine, Prevention and Control of Infectious Disease of Zhejiang Province, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
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Rong Zhang
Rong Zhang
Key Laboratory of Vaccine, Prevention and Control of Infectious Disease of Zhejiang Province, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
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Xuguang Shi
Xuguang Shi
Key Laboratory of Vaccine, Prevention and Control of Infectious Disease of Zhejiang Province, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
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Jiangping Ren
Jiangping Ren
Key Laboratory of Vaccine, Prevention and Control of Infectious Disease of Zhejiang Province, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
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Song Guo
Song Guo
Key Laboratory of Vaccine, Prevention and Control of Infectious Disease of Zhejiang Province, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
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Jimin Sun
Jimin Sun
Key Laboratory of Vaccine, Prevention and Control of Infectious Disease of Zhejiang Province, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
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Jianmin Jiang
Jianmin Jiang
Key Laboratory of Vaccine, Prevention and Control of Infectious Disease of Zhejiang Province, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
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ABSTRACT.
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease worldwide. It can be transmitted from person to person, and the fatality rate is very high. During this study, three SFTS clusters including 12 associated cases were identified in three counties in Zhejiang Province from 2018 to 2020. The median age of the three index patients was 70 years, and that of secondary case patients was 59 years. Of note, the mortality rate of the index patients was 100%. The mortality rate of secondary case patients was 11%. The total secondary attack rate (SAR) was 30% (9/30). The SARs of cluster A, cluster B, and cluster C were 38% (3/8), 21% (3/14), and 38% (3/8), respectively. Additionally, the interval from onset to diagnosis was 4 days. The intervals from disease onset to confirmation of the index cases and secondary cases were 7 days and 4 days, respectively. All secondary case patients had a history of close contact with blood or body fluids of the index patients. These results indicate that SFTS patients should not be discharged until recovery. When SFTS patients die, the corpses should be transferred directly from the hospital to the crematorium for cremation by persons wearing proper protective equipment to prevent virus transmission.
Author Notes
Financial support: This study was supported by National Natural Science Funds of China (no. 81872675), a grant from the Science Technology Department of Zhejiang Province (no. LGF20H260001), the state project for scientific & technological development of the 13th 5-year plan in China (no. 2017ZX10303404008002), and the medical health science and technology project of Zhejiang Provincial Health Commission (no. 2019KY060).
Authors’ addresses: Mingyong Tao, Ningbo University, Medical School, Ningbo, Zhejiang, China, E-mail: 1911101035@nbu.edu.cn. Ying Liu, Feng Ling, Rong Zhang, Xuguang Shi, Jiangping Ren, Song Guo, Jimin Sun, and Jianmin Jiang, Key Laboratory of Vaccine, Prevention and Control of Infectious Disease of Zhejiang Province, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China, E-mails: yliu@cdc.zj.cn, fengl@cdc.zj.cn, rzhang@cdc.zj.cn, xgshi@cdc.zj.cn, jpren@cdc.zj.cn, sguo@cdc.zj.cn, jmsun@cdc.zj.cn, and jmjiang@cdc.zj.cn.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Yu XJ , 2011. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364: 1523–1532.
-
2.
Deng B , Zhou B , Zhang S , Zhu Y , Han L , Geng Y , Jin Z , Liu H , Wang D , Zhao Y , 2013. Clinical features and factors associated with severity and fatality among patients with severe fever with thrombocytopenia syndrome bunyavirus infection in northeast China. PLoS One 8: e80802.
-
3.
Ding YP , Liang MF , Ye J , Liu Q , Xiong C , Long B , Lin W , Cui N , Zou Z , Song Y , 2014. Prognostic value of clinical and immunological markers in acute phase of SFTS virus infection. Clin Microbiol Infect 20: O870–O878.
-
4.
Gai Z , Liang M , Zhang Y , Zhang S , Jin C , Wang SW , Sun L , Zhou N , Zhang Q , Sun Y , 2012. Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact. Clin Infect Dis 54: 249–252.
-
5.
Liu MM , Lei XY , Yu XJ , 2016. Meta-analysis of the clinical and laboratory parameters of SFTS patients in China. Virol J 13: 1–6.
-
6.
Sun J , Lu L , Wu H , Yang J , Liu K , Liu Q , 2018. Spatiotemporal patterns of severe fever with thrombocytopenia syndrome in China, 2011–2016. Ticks Tick Borne Dis 9: 927–933.
-
7.
Kim KH et al.2013. Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis 19: 1892–1894.
-
8.
Takahashi T et al., 2014. The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan. J Infect Dis 209: 816–827.
-
9.
Tran XC , Yun Y , Le Van An SHK , Thao NTP , Man PKC , Yoo JR , Heo ST , Cho N-H , Lee KH , 2019. Endemic severe fever with thrombocytopenia syndrome, Vietnam. Emerg Infect Dis 25: 1029.
-
10.
McMullan LK et al., 2012. A new phlebovirus associated with severe febrile illness in Missouri. N Engl J Med 367: 834–841.
-
11.
Kohl C , Brinkmann A , Radonic A , Dabrowski PW , Nitsche A , Muhldorfer K , Wibbelt G , Kurth A , 2020. Zwiesel bat banyangvirus, a potentially zoonotic Huaiyangshan banyangvirus (formerly known as SFTS)-like banyangvirus in northern bats from Germany. Sci Rep 10: 1370.
-
12.
Luo LM , Zhao L , Wen HL , Zhang ZT , Liu JW , Fang LZ , Xue ZF , Ma DQ , Zhang XS , Ding SJ , 2015. Haemaphysalis longicornis ticks as reservoir and vector of severe fever with thrombocytopenia syndrome virus in China. Emerg Infect Dis 21: 1770.
-
13.
Tang X et al., 2013. Human-to-human transmission of severe fever with thrombocytopenia syndrome bunyavirus through contact with infectious blood. J Infect Dis 207: 736–739.
-
14.
Liu JW et al., 2014. Prevalence of SFTSV among Asian house shrews and rodents, China, January–August 2013. Emerg Infect Dis 20: 2126–2128.
-
15.
Niu G , Li J , Liang M , Jiang X , Jiang M , Yin H , Wang Z , Li C , Zhang Q , Jin C , 2013. Severe fever with thrombocytopenia syndrome virus among domesticated animals, China. Emerg Infect Dis 19: 756.
-
16.
Huang XY , Du YH , Wang HF , You AG , Li Y , Su J , Nie YF , Ma HX , Xu BL , 2019. Prevalence of severe fever with thrombocytopenia syndrome virus in animals in Henan Province, China. Infect Dis Poverty 8: 56.
-
17.
Kida K et al., 2019. A case of cat-to-human transmission of severe fever with thrombocytopenia syndrome virus. Jpn J Infect Dis 72: 356–358.
-
18.
Liu Y , Li Q , Hu W , Wu J , Wang Y , Mei L , Walker DH , Ren J , Wang Y , Yu XJ , 2012. Person-to-person transmission of severe fever with thrombocytopenia syndrome virus. Vector Borne Zoonotic Dis 12: 156–160.
-
19.
Chen H , Hu K , Zou J , Xiao J , 2013. A cluster of cases of human-to-human transmission caused by severe fever with thrombocytopenia syndrome bunyavirus. Int J Infect Dis 17: e206–e208.
-
20.
Jiang XL et al., 2015. A cluster of person-to-person transmission cases caused by SFTS virus in Penglai, China. Clin Microbiol Infect 21: 274–279.
-
21.
Wang S , Li J , Niu G , Wang X , Ding S , Jiang X , Li C , Zhang Q , Liang M , Bi Z , 2015. SFTS virus in ticks in an endemic area of China. Am J Trop Med Hyg 92: 684–689.
-
22.
Gong Z , Gu S , Zhang Y , Sun J , Wu X , Ling F , Shi W , Zhang P , Li D , Mao H , 2015. Probable aerosol transmission of severe fever with thrombocytopenia syndrome virus in southeastern China. Clin Microbiol Infect 21: 1115–1120.
-
23.
Moon J et al., 2018. Aerosol transmission of severe fever with thrombocytopenia syndrome virus during resuscitation. Infect Control Hosp Epidemiol 40: 238–241.
-
24.
Zhan J , Wang Q , Cheng J , Hu B , Li J , Zhan F , Song Y , Guo D , 2017. Current status of severe fever with thrombocytopenia syndrome in China. Virol Sin 32: 51–62.
-
25.
Sun J , Tang Y , Ling F , Chang Y , Ye X , Shi W , Zhang L , Chen Z , Lin H , Qiu Z , 2015. Genetic susceptibility is one of the determinants for severe fever with thrombocytopenia syndrome virus infection and fatal outcome: an epidemiological investigation. PLoS One 10: e0132968.
-
26.
Sun J et al., 2014. Epidemiological characteristics of severe fever with thrombocytopenia syndrome in Zhejiang Province, China. Int J Infect Dis 25: 180–185.
-
27.
Sun J et al., 2016. Factors associated with severe fever with thrombocytopenia syndrome infection and fatal outcome. Sci Rep 6: 33175.
-
28.
Lin G , 2013. From “dying without a burial place” to “resting in peace”: research on the reform of Chinese funeral service system under the four-dimensional visual threshold. J Zhejiang Univ Humanit Soc Sci 3: 1–2.
-
29.
Ming W , 2012. The immortal of trailbreaker: the image and character of Fangxiang in ancient Chinese funeral ritual. J Tsinghua Univ Soc Sci 2: 116–125.
-
30.
Kun Q , 2014. Sonic expressions of cosmological awareness: a comparative study of funeral rituals among Han Chinese living in the Yangzi River Valley. Yearb Tradit Music 46: 159–169.
-
31.
Chan CLW , Chow AYM , Ho SMY , Tsui YKY , Tin AF , Koo BWK , Koo EWK , 2005. The experience of Chinese bereaved persons: a preliminary study of meaning making and continuing bonds. Death Stud 29: 923–947.
-
32.
National Health Commission of the People’s Republic of China , 2011. Points for Prevention and Control of Spread of Severe Syndrome with Thrombocytopenia by Contact. Available at: http://www.nhc.gov.cn/zwgk/wtwj/201304/447234f04fb54e38b91a2b1b900aa27d.shtml. Accessed August 12, 2011.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1237 | 378 | 19 |
| Full Text Views | 396 | 36 | 1 |
| PDF Downloads | 185 | 20 | 1 |