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Reference Manager
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Zotero
EndNote
-
1.
Johnson JR et al. 2007. Antimicrobial drug-resistant Escherichia coli from humans and poultry products, Minnesota and Wisconsin, 2002–2004. Emerg Infect Dis 13: 838–846.
-
2.
Nikolich MP, Hong G, Shoemaker NB, Salyers AA, 1994. Evidence for natural horizontal transfer of tetQ between bacteria that normally colonize humans and bacteria that normally colonize livestock. Appl Environ Microbiol 60: 3255–3260.
-
3.
Miles TD, McLaughlin W, Brown PD, 2006. Antimicrobial resistance of Escherichia coli isolates from broiler chickens and humans. BMC Vet Res 2: 7.
-
4.
Rousham EK, Unicomb L, Islam MA, 2018. Human, animal and environmental contributors to antibiotic resistance in low-resource settings: integrating behavioural, epidemiological and one health approaches. Proc Biol Sci 285: 20180332.
-
5.
WHO, 2014. Global Report on Surveillance: Antimicrobial Resistance. Geneva, Switzerland: World Health Organization.
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6.
Collignon P, Powers JH, Chiller TM, Aidara-Kane A, Aarestrup FM, 2009. World Health Organization ranking of antimicrobials according to their importance in human medicine: a critical step for developing risk management strategies for the use of antimicrobials in food production animals. Clin Infect Dis 49: 132–141.
-
7.
Founou RC, Founou LL, Essack SY, 2017. Clinical and economic impact of antibiotic resistance in developing countries: a systematic review and meta-analysis. PLoS One 12: e0189621.
-
8.
Roess AA et al. 2015. Household animal and human medicine use and animal husbandry practices in rural Bangladesh: risk factors for emerging zoonotic disease and antibiotic resistance. Zoonoses Public Health 62: 569–578.
-
9.
Ngure F et al. 2019. Exposure to livestock feces and water quality, sanitation, and hygiene (WASH) conditions among caregivers and young children: formative research in rural Burkina Faso. Am J Trop Med Hyg 100: 998–1004.
-
10.
Ercumen A, Prottas C, Harris A, Dioguardi A, Dowd G, Guiteras R, 2020. Poultry ownership associated with increased risk of child diarrhea: cross-sectional evidence from Uganda. Am J Trop Med Hyg 102: 526–533.
-
11.
Oldenburg CE et al. 2018. Effect of commonly used pediatric antibiotics on gut microbial diversity in preschool children in Burkina Faso: a randomized clinical trial. Open Forum Infect Dis 5: ofy289.
-
12.
Sie A et al. 2018. Effect of antibiotics on short-term growth among children in Burkina Faso: a randomized trial. Am J Trop Med Hyg 99: 789–796.
-
13.
Sie A et al. 2018. Dietary diversity and nutritional status among children in rural Burkina Faso. Int Health 10: 157–162.
-
14.
Oldenburg CE et al. 2020. Gut resistome after oral antibiotics in preschool children in Burkina Faso: a randomized, controlled trial. Clin Infect Dis 70: 525–527.
-
15.
Debela MD, Muyanja DM, Kakuhikire B, Baguma C, Bangsberg DR, Tsai AC, Weil AA, Lai PS, 2018. Acquisition and quantification of antimicrobial resistance genes in the gut microbiome of Ugandan women exposed to small-scale chicken farming. Open Forum Infect Dis 5: S366.
-
16.
Molechan C, Amoako DG, Abia ALK, Somboro AM, Bester LA, Essack SY, 2019. Molecular epidemiology of antibiotic-resistant Enterococcus spp. from the farm-to-fork continuum in intensive poultry production in KwaZulu-Natal, South Africa. Sci Total Environ. 692: 868–878.
-
17.
Kyakuwaire M, Olupot G, Amoding A, Nkedi-Kizza P, Basamba TA, 2019. How safe is chicken litter for land application as an organic fertilizer? A review. Int J Environ Res Public Health 16: E3521.
-
18.
Mahmoud MAM, Abdel-Mohsein HS, 2019. Hysterical tetracycline in intensive poultry farms accountable for substantial gene resistance, health and ecological risk in Egypt- manure and fish. Environ Pollut 255: 113039.
-
19.
Manyi-Loh C, Mamphweli S, Meyer E, Okoh A, 2018. Antibiotic use in agriculture and its consequential resistance in environmental sources: potential public health implications. Molecules 23: 795.
-
20.
Ventola CL, 2015. The antibiotic resistance: part 1: causes and threats. P&T 40: 277–283.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 3058 | 2371 | 122 |
| Full Text Views | 416 | 76 | 2 |
| PDF Downloads | 208 | 15 | 2 |
Poultry Ownership and Genetic Antibiotic Resistance Determinants in the Gut of Preschool Children
Jessica M. Brogdon
Jessica M. Brogdon
Francis I Proctor Foundation, University of California, San Francisco, San Francisco, California;
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Ali Sié
Ali Sié
Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso;
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Clarisse Dah
Clarisse Dah
Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso;
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Lucienne Ouermi
Lucienne Ouermi
Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso;
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Boubacar Coulibaly
Boubacar Coulibaly
Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso;
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Elodie Lebas
Elodie Lebas
Francis I Proctor Foundation, University of California, San Francisco, San Francisco, California;
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Lina Zhong
Lina Zhong
Francis I Proctor Foundation, University of California, San Francisco, San Francisco, California;
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Cindi Chen
Cindi Chen
Francis I Proctor Foundation, University of California, San Francisco, San Francisco, California;
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Thomas M. Lietman
Thomas M. Lietman
Francis I Proctor Foundation, University of California, San Francisco, San Francisco, California;
Department of Ophthalmology, University of California, San Francisco, San Francisco, California;
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California
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Department of Ophthalmology, University of California, San Francisco, San Francisco, California;
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California
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Jeremy D. Keenan
Jeremy D. Keenan
Francis I Proctor Foundation, University of California, San Francisco, San Francisco, California;
Department of Ophthalmology, University of California, San Francisco, San Francisco, California;
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California
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Department of Ophthalmology, University of California, San Francisco, San Francisco, California;
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California
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Thuy Doan
Thuy Doan
Francis I Proctor Foundation, University of California, San Francisco, San Francisco, California;
Department of Ophthalmology, University of California, San Francisco, San Francisco, California;
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Department of Ophthalmology, University of California, San Francisco, San Francisco, California;
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Catherine E. Oldenburg
Catherine E. Oldenburg
Francis I Proctor Foundation, University of California, San Francisco, San Francisco, California;
Department of Ophthalmology, University of California, San Francisco, San Francisco, California;
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California
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Department of Ophthalmology, University of California, San Francisco, San Francisco, California;
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ABSTRACT
Zoonotic transmission is likely a pathway for antibiotic resistance. Data from a randomized trial of pediatric antibiotic administration were secondarily evaluated to determine if poultry ownership was significantly associated with the presence of gut genetic antibiotic resistance determinants among 118 children in Burkina Faso. Antimicrobial resistance (AMR) determinants were classified using DNA sequencing. We measured the relationship between genetic resistance determinants and chicken ownership using a logistic regression model adjusted for confounding variables. Children in households reporting poultry ownership had four times the odds of tetracycline resistance determinants in the gut compared with those without household poultry (odds ratio [OR]: 4.08, 95% CI: 1.08–15.44, P = 0.04). There was no statistically significant difference found for other antibiotic classes. Understanding the origins of antibiotic resistance may help spur the development of interventions to combat the global AMR crisis.
Author Notes
Disclosure: All authors submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.
Financial support: This trial was supported by the National Eye Institute of the NIH under award K08EY026986 and by the Research to Prevent Blindness Career Development Award.
Authors’ addresses: Jessica M. Brogdon, Elodie Lebas, Lina Zhong, Cindi Chen, Thomas Lietman, Thuy Doan, and Catherine E. Oldenburg, Francis I Proctor Foundation, University of California, San Francisco, San Francisco, CA, E-mails: jessica.brogdon@ucsf.edu, elodie.Lebas@ucsf.edu, lina.zhong@ucsf.edu, cindi.chen@ucsf.edu, tom.lietman@ucsf.edu, thuy.doan@ucsf.edu, and catherine.oldenburg@ucsf.edu. Ali Sié, Clarisse Dah, Lucienne Ouermi, and Boubacar Coulibaly, Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso, E-mails: alisie@yahoo.fr, n.clarissedah@yahoo.fr, ouermil@yahoo.fr, and boubacar@fasonet.bf. Jeremy D. Keenan, F.I. Proctor Foundation and Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, E-mail: jessica.brogdon@ucsf.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Johnson JR et al. 2007. Antimicrobial drug-resistant Escherichia coli from humans and poultry products, Minnesota and Wisconsin, 2002–2004. Emerg Infect Dis 13: 838–846.
-
2.
Nikolich MP, Hong G, Shoemaker NB, Salyers AA, 1994. Evidence for natural horizontal transfer of tetQ between bacteria that normally colonize humans and bacteria that normally colonize livestock. Appl Environ Microbiol 60: 3255–3260.
-
3.
Miles TD, McLaughlin W, Brown PD, 2006. Antimicrobial resistance of Escherichia coli isolates from broiler chickens and humans. BMC Vet Res 2: 7.
-
4.
Rousham EK, Unicomb L, Islam MA, 2018. Human, animal and environmental contributors to antibiotic resistance in low-resource settings: integrating behavioural, epidemiological and one health approaches. Proc Biol Sci 285: 20180332.
-
5.
WHO, 2014. Global Report on Surveillance: Antimicrobial Resistance. Geneva, Switzerland: World Health Organization.
-
6.
Collignon P, Powers JH, Chiller TM, Aidara-Kane A, Aarestrup FM, 2009. World Health Organization ranking of antimicrobials according to their importance in human medicine: a critical step for developing risk management strategies for the use of antimicrobials in food production animals. Clin Infect Dis 49: 132–141.
-
7.
Founou RC, Founou LL, Essack SY, 2017. Clinical and economic impact of antibiotic resistance in developing countries: a systematic review and meta-analysis. PLoS One 12: e0189621.
-
8.
Roess AA et al. 2015. Household animal and human medicine use and animal husbandry practices in rural Bangladesh: risk factors for emerging zoonotic disease and antibiotic resistance. Zoonoses Public Health 62: 569–578.
-
9.
Ngure F et al. 2019. Exposure to livestock feces and water quality, sanitation, and hygiene (WASH) conditions among caregivers and young children: formative research in rural Burkina Faso. Am J Trop Med Hyg 100: 998–1004.
-
10.
Ercumen A, Prottas C, Harris A, Dioguardi A, Dowd G, Guiteras R, 2020. Poultry ownership associated with increased risk of child diarrhea: cross-sectional evidence from Uganda. Am J Trop Med Hyg 102: 526–533.
-
11.
Oldenburg CE et al. 2018. Effect of commonly used pediatric antibiotics on gut microbial diversity in preschool children in Burkina Faso: a randomized clinical trial. Open Forum Infect Dis 5: ofy289.
-
12.
Sie A et al. 2018. Effect of antibiotics on short-term growth among children in Burkina Faso: a randomized trial. Am J Trop Med Hyg 99: 789–796.
-
13.
Sie A et al. 2018. Dietary diversity and nutritional status among children in rural Burkina Faso. Int Health 10: 157–162.
-
14.
Oldenburg CE et al. 2020. Gut resistome after oral antibiotics in preschool children in Burkina Faso: a randomized, controlled trial. Clin Infect Dis 70: 525–527.
-
15.
Debela MD, Muyanja DM, Kakuhikire B, Baguma C, Bangsberg DR, Tsai AC, Weil AA, Lai PS, 2018. Acquisition and quantification of antimicrobial resistance genes in the gut microbiome of Ugandan women exposed to small-scale chicken farming. Open Forum Infect Dis 5: S366.
-
16.
Molechan C, Amoako DG, Abia ALK, Somboro AM, Bester LA, Essack SY, 2019. Molecular epidemiology of antibiotic-resistant Enterococcus spp. from the farm-to-fork continuum in intensive poultry production in KwaZulu-Natal, South Africa. Sci Total Environ. 692: 868–878.
-
17.
Kyakuwaire M, Olupot G, Amoding A, Nkedi-Kizza P, Basamba TA, 2019. How safe is chicken litter for land application as an organic fertilizer? A review. Int J Environ Res Public Health 16: E3521.
-
18.
Mahmoud MAM, Abdel-Mohsein HS, 2019. Hysterical tetracycline in intensive poultry farms accountable for substantial gene resistance, health and ecological risk in Egypt- manure and fish. Environ Pollut 255: 113039.
-
19.
Manyi-Loh C, Mamphweli S, Meyer E, Okoh A, 2018. Antibiotic use in agriculture and its consequential resistance in environmental sources: potential public health implications. Molecules 23: 795.
-
20.
Ventola CL, 2015. The antibiotic resistance: part 1: causes and threats. P&T 40: 277–283.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 3058 | 2371 | 122 |
| Full Text Views | 416 | 76 | 2 |
| PDF Downloads | 208 | 15 | 2 |