ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2015. Investing to Overcome the Global Impact of Neglected Tropical Diseases. Available at: http://apps.who.int/iris/bitstream/handle/10665/152781/9789241564861_eng.pdf;jsessionid=18597B05AB847F722F55E597A5ED356C?sequence=1. Accessed November 11, 2018.
-
2.
Bhatt S et al. 2013. The global distribution and burden of dengue. Nature 496: 504–507.
-
3.
World Health Organization, 2009. Dengue: Guidelines for Diagnosis, Treatment Prevention and Control. New edition. Available at: http://apps.who.int/iris/bitstream/handle/10665/44188/9789241547871_eng.pdf?sequence=1. Accessed November 11, 2018.
-
4.
Ministry of Health, Labour and Welfare. Dengue Fever, Notification from Physician and Veterinarian Based on Infectious Disease Act. Available at: https://www.mhlw.go.jp/bunya/kenkou/kekkaku-kansenshou11/01-04-19.html. Accessed May 27, 2019.
-
5.
National Institute of Infectious Diseases, 2016. Category IV, Annual Surveillance Data Table -2016- (Japanese). Available at: https://www.niid.go.jp/niid/ja/survei/2085-idwr/ydata/7310-report-ja2016-20.html. Accessed August 12, 2018.
-
6.
National Institute of Infectious Diseases, 2016. Dengue Virus Infection Information (Japanese). Available at: http://www0.nih.go.jp/vir1/NVL/dengue.htm. Accessed August 12, 2018.
-
7.
Japan International Corporation of Welfare Services, 2015. Infection Is Not a Problem for Single Country: As an Example the Ebola Hemorrhagic Fever and Dengue Fever.
-
8.
Tajima S, Nakayama E, Kotaki A, Moi ML, Ikeda M, Yagasaki K, Saito Y, Shibasaki KI, Saijo M, Takasaki T, 2017. Whole genome sequencing-based molecular epidemiologic analysis of autochthonous dengue virus type 1 strains circulating in Japan in 2014. Jpn J Infect Dis 70: 45–49.
-
9.
Tokyo Metropolitan Government, 2014. Tokyo Mosquito-Borne Disease Countermeasure Meeting. Report Appendix 2. Available at: http://www.metro.tokyo.jp/INET/KONDAN/2014/12/DATA/40oco101.pdf. Accessed May 1, 2019.
-
10.
Hamada A et al. 2014. Dengue Clinical Guideline (Japanese), 1st edition. Available at: https://www.mhlw.go.jp/file/04-Houdouhappyou-10906000-Kenkoukyoku-Kekkakukansenshouka/0000057969.pdf. Accessed November 11, 2018.
-
11.
Lye DC et al. 2017. Prophylactic platelet transfusion plus supportive care versus supportive care alone in adults with dengue and thrombocytopenia: a multicentre, open-label, randomised, superiority trial. Lancet 389: 1611–1618.
-
12.
Ministry of health, Labour and Welfare. Changes in Electric Claims Data at Medical Institution Based on Numbers of Claims Data. Available at: https://www.mhlw.go.jp/file/06-Seisakujouhou-12400000-Hokenkyoku/0000099002.pdf. Accessed August 8, 2018.
-
13.
Ministry of Health, Labour and Welfare, 2016. Guideline for Provision of Claims Data and Special Health Checkup Result etc. 2015 (Japanese). Available at: https://www.mhlw.go.jp/file/05-Shingikai-12401000-Hokenkyoku-Soumuka/0000135460.pdf. Accessed August 19, 2018.
-
14.
Teixeira MG, Costa MC, Coelho G, Barreto ML, 2008. Recent shift in age pattern of dengue hemorrhagic fever, Brazil. Emerg Infect Dis 14: 1663.
-
15.
Pemde HK, Dutta AK, Sodani R, Mishra K, 2015. Isotonic intravenous maintenance fluid reduces hospital acquired hyponatremia in young children with central nervous system infections. Indian J Pediatr 82: 13–18.
-
16.
Leroy PL, Hoorn EJ, 2017. Should we use hypotonic or isotonic maintenance intravenous fluids in sick patients? Why a study in healthy volunteers will not provide the answer: response to: effect of isotonic versus hypotonic maintenance fluid therapy on urine output, fluid balance, and electrolyte homeostasis: a crossover study in fasting adult volunteers. Br J Anaesth.119: 836–837.
-
17.
García Rodríguez LA, Barreales Tolosa L, 2007. Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population. Gastroenterology 132: 498–506.
-
18.
Yuhara H, Corley DA, Nakahara F, Nakajima T, Koike J, Igarashi M, Suauki T, Mine T, 2014. Aspirin and non-aspirin NSAIDs increase risk of colonic diverticular bleeding: a systematic review and meta-analysis. J Gastroenterol 49: 992–1000.
-
19.
Ministry of Health, Labour and Welfare, 2018. Information Regarding to Drug Price Standard Items List and Generic Drugs (Japanese). Available at: https://www.mhlw.go.jp/topics/2018/04/tp20180401-01.html. Accessed August 21, 2018.
-
20.
Organisation for Economic Co-operation and Development. Purchasing Power Parities for GDP and Related Indicators. Available at: https://stats.oecd.org/Index.aspx?DataSetCode=PPPGDP. Accessed August 5, 2018.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 475 | 366 | 52 |
| Full Text Views | 973 | 18 | 1 |
| PDF Downloads | 345 | 19 | 1 |
Clinical Management of Patients with Dengue Infection in Japan: Results from National Database of Health Insurance Claims
Yusuke Kajimoto
Yusuke Kajimoto
Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan;
Global Health Research Coordinating Center, Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan;
Search for other papers by Yusuke Kajimoto in
Current site
Google Scholar
PubMed
Global Health Research Coordinating Center, Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan;
Search for other papers by Yusuke Kajimoto in
Current site
Google Scholar
PubMed
Tsutomu Kitajima
Tsutomu Kitajima
Faculty of Social Sciences, Kyorin University, Tokyo, Japan
Search for other papers by Tsutomu Kitajima in
Current site
Google Scholar
PubMed
Search for other papers by Tsutomu Kitajima in
Current site
Google Scholar
PubMed
Dengue guidelines for diagnosis, treatment, prevention, and control (WHO, 2011) recommend acetaminophen and isotonic fluid for patients with dengue infection but do not recommend nonsteroidal anti-inflammatory drugs (NSAIDs) and hypotonic fluid. Other research showed no evidence of efficacy of platelet infusion in prophylactic. This research aims to clarify to what extent dengue patients were managed in accordance with the guidelines in Japan. We extracted claim data of patients with either dengue fever (DF) or dengue hemorrhagic fever (DHF) from the National Database of Health Insurance Claims and Specific Health Checkups of Japan between 2011 and 2015. The total number of patients was 1,370, which consisted of 1,306 DF patients and 64 DHF patients; 185 patients were younger than (<) 20 years and 1,185 patients were aged 20 years or older (≥). Among them, 24.5% of DF patients and 48.4% of DHF patients received hypotonic intravenous fluid, 12.9% and 18.8% NSAIDs, and 1.3% and 17.2% platelet transfusion, respectively. Comparing patients aged < 20 years with patients aged ≥ 20 years, 57.8% and 54.5% received acetaminophen, 6.5% and 14.3% received NSAIDs, 40.0% and 38.3% received isotonic fluid, and 37.8% and 23.7% received hypotonic fluid, respectively. Platelet transfusion was used for 1.3% of DH and 17.2% of DHF patients. The study indicated that dengue patients in Japan might have increased risks of developing adverse events because of receiving the treatment that the guidelines do not recommend. More effort is needed to facilitate medical practitioners to follow the guidelines.
Author Notes
Authors’ addresses: Yusuke Kajimoto, Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan, and Global Health Research Coordinating Center, Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan, E-mail: ykajimoto234@g.ecc.u-tokyo.ac.jp. Tsutomu Kitajima, Faculty of Social Sciences, Kyorin University, Tokyo, Japan, E-mail: kitajima@ks.kyorin-u.ac.jp.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2015. Investing to Overcome the Global Impact of Neglected Tropical Diseases. Available at: http://apps.who.int/iris/bitstream/handle/10665/152781/9789241564861_eng.pdf;jsessionid=18597B05AB847F722F55E597A5ED356C?sequence=1. Accessed November 11, 2018.
-
2.
Bhatt S et al. 2013. The global distribution and burden of dengue. Nature 496: 504–507.
-
3.
World Health Organization, 2009. Dengue: Guidelines for Diagnosis, Treatment Prevention and Control. New edition. Available at: http://apps.who.int/iris/bitstream/handle/10665/44188/9789241547871_eng.pdf?sequence=1. Accessed November 11, 2018.
-
4.
Ministry of Health, Labour and Welfare. Dengue Fever, Notification from Physician and Veterinarian Based on Infectious Disease Act. Available at: https://www.mhlw.go.jp/bunya/kenkou/kekkaku-kansenshou11/01-04-19.html. Accessed May 27, 2019.
-
5.
National Institute of Infectious Diseases, 2016. Category IV, Annual Surveillance Data Table -2016- (Japanese). Available at: https://www.niid.go.jp/niid/ja/survei/2085-idwr/ydata/7310-report-ja2016-20.html. Accessed August 12, 2018.
-
6.
National Institute of Infectious Diseases, 2016. Dengue Virus Infection Information (Japanese). Available at: http://www0.nih.go.jp/vir1/NVL/dengue.htm. Accessed August 12, 2018.
-
7.
Japan International Corporation of Welfare Services, 2015. Infection Is Not a Problem for Single Country: As an Example the Ebola Hemorrhagic Fever and Dengue Fever.
-
8.
Tajima S, Nakayama E, Kotaki A, Moi ML, Ikeda M, Yagasaki K, Saito Y, Shibasaki KI, Saijo M, Takasaki T, 2017. Whole genome sequencing-based molecular epidemiologic analysis of autochthonous dengue virus type 1 strains circulating in Japan in 2014. Jpn J Infect Dis 70: 45–49.
-
9.
Tokyo Metropolitan Government, 2014. Tokyo Mosquito-Borne Disease Countermeasure Meeting. Report Appendix 2. Available at: http://www.metro.tokyo.jp/INET/KONDAN/2014/12/DATA/40oco101.pdf. Accessed May 1, 2019.
-
10.
Hamada A et al. 2014. Dengue Clinical Guideline (Japanese), 1st edition. Available at: https://www.mhlw.go.jp/file/04-Houdouhappyou-10906000-Kenkoukyoku-Kekkakukansenshouka/0000057969.pdf. Accessed November 11, 2018.
-
11.
Lye DC et al. 2017. Prophylactic platelet transfusion plus supportive care versus supportive care alone in adults with dengue and thrombocytopenia: a multicentre, open-label, randomised, superiority trial. Lancet 389: 1611–1618.
-
12.
Ministry of health, Labour and Welfare. Changes in Electric Claims Data at Medical Institution Based on Numbers of Claims Data. Available at: https://www.mhlw.go.jp/file/06-Seisakujouhou-12400000-Hokenkyoku/0000099002.pdf. Accessed August 8, 2018.
-
13.
Ministry of Health, Labour and Welfare, 2016. Guideline for Provision of Claims Data and Special Health Checkup Result etc. 2015 (Japanese). Available at: https://www.mhlw.go.jp/file/05-Shingikai-12401000-Hokenkyoku-Soumuka/0000135460.pdf. Accessed August 19, 2018.
-
14.
Teixeira MG, Costa MC, Coelho G, Barreto ML, 2008. Recent shift in age pattern of dengue hemorrhagic fever, Brazil. Emerg Infect Dis 14: 1663.
-
15.
Pemde HK, Dutta AK, Sodani R, Mishra K, 2015. Isotonic intravenous maintenance fluid reduces hospital acquired hyponatremia in young children with central nervous system infections. Indian J Pediatr 82: 13–18.
-
16.
Leroy PL, Hoorn EJ, 2017. Should we use hypotonic or isotonic maintenance intravenous fluids in sick patients? Why a study in healthy volunteers will not provide the answer: response to: effect of isotonic versus hypotonic maintenance fluid therapy on urine output, fluid balance, and electrolyte homeostasis: a crossover study in fasting adult volunteers. Br J Anaesth.119: 836–837.
-
17.
García Rodríguez LA, Barreales Tolosa L, 2007. Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population. Gastroenterology 132: 498–506.
-
18.
Yuhara H, Corley DA, Nakahara F, Nakajima T, Koike J, Igarashi M, Suauki T, Mine T, 2014. Aspirin and non-aspirin NSAIDs increase risk of colonic diverticular bleeding: a systematic review and meta-analysis. J Gastroenterol 49: 992–1000.
-
19.
Ministry of Health, Labour and Welfare, 2018. Information Regarding to Drug Price Standard Items List and Generic Drugs (Japanese). Available at: https://www.mhlw.go.jp/topics/2018/04/tp20180401-01.html. Accessed August 21, 2018.
-
20.
Organisation for Economic Co-operation and Development. Purchasing Power Parities for GDP and Related Indicators. Available at: https://stats.oecd.org/Index.aspx?DataSetCode=PPPGDP. Accessed August 5, 2018.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 475 | 366 | 52 |
| Full Text Views | 973 | 18 | 1 |
| PDF Downloads | 345 | 19 | 1 |