- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- Opisthorchiasis increases the liver-to-body weight ratio in HFF diet–fed hamsters.
- Opisthorchiasis increases IR in HFF diet–fed hamsters.
- Opisthorchiasis causes dyslipidemia during HFF diet.
- Opisthorchis viverrini infection augments the severity of NAFLD in HFF diet–fed hamsters.
- Opisthorchiasis induces organelle abnormalities in hepatocytes of hamsters fed HFF diet.
- DISCUSSION
- Supplemental table appears
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Sithithaworn P, Andrews RH, Nguyen VD, Wongsaroj T, Sinuon M, Odermatt P, Nawa Y, Liang S, Brindley PJ, Sripa B, 2012. The current status of opisthorchiasis and clonorchiasis in the Mekong basin. Parasitol Int 61: 10–16.
-
2.
Jittimanee J, Sermswan RW, Puapairoj A, Maleewong W, Wongratanacheewin S, 2007. Cytokine expression in hamsters experimentally infected with Opisthorchis viverrini. Parasite Immunol 29: 159–167.
-
3.
Prakobwong S, Pinlaor S, Yongvanit P, Sithithaworn P, Pairojkul C, Hiraku Y, 2009. Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagens in hamsters infected with Opisthorchis viverrini with special reference to peribiliary fibrosis and liver injury. Int J Parasitol 39: 825–835.
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Laothong U, Pinlaor P, Boonsiri P, Hiraku Y, Khoontawad J, Hongsrichan N, Charoensuk L, Pinlaor S, 2013. α-Tocopherol and lipid profiles in plasma and the expression of alpha-tocopherol-related molecules in the liver of Opisthorchis viverrini-infected hamsters. Parasitol Int 62: 127–133.
-
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Adam R, Hinz E, Sithithaworn P, Pipitgool V, Storch V, 1993. Ultrastructural hepatic alterations in hamsters and jirds after experimental infection with the liver fluke Opisthorchis viverrini. Parasitol Res 79: 357–364.
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Laothong U, Pinlaor P, Boonsiri P, Pairojkul C, Priprem A, Johns NP, Charoensuk L, Intuyod K, Pinlaor S, 2013. Melatonin inhibits cholangiocarcinoma and reduces liver injury in Opisthorchis viverrini-infected and N-nitrosodimethylamine-treated hamsters. J Pineal Res 55: 257–266.
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Chaidee A et al. 2018. Co-occurrence of opisthorchiasis and diabetes exacerbates morbidity of the hepatobiliary tract disease. Plos Negl Trop Dis 12: e0006611.
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Rinella ME, 2015. Nonalcoholic fatty liver disease: a systematic review. JAMA 313: 2263–2273.
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Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M, Landt CL, Harrison SA, 2011. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 140: 124–131.
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Birkenfeld AL, Shulman GI, 2014. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology 59: 713–723.
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Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M, 2016. Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 64: 73–84.
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Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J, Bugianesi E, 2018. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol 15: 11–20.
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Tacke F, Yoneyama H, 2013. From NAFLD to NASH to fibrosis to HCC: role of dendritic cell populations in the liver. Hepatology 58: 494–496.
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Chen Y, Yousaf MN, Mehal WZ, 2018. Role of sterile inflammation in fatty liver diseases. Liver Res 2: 21–29.
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Ganz M, Bukong TN, Csak T, Saha B, Park JK, Ambade A, Kodys K, Szabo G, 2015. Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice. J Transl Med 13: 193.
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Angulo P et al. 2015. Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology 149: 389–397 e10.
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Kanwal F et al. 2018. Risk of hepatocellular cancer in patients with non-alcoholic fatty liver disease. Gastroenterology 155: 1828–1837 e2.
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Opisthorchis viverrini Infection Augments the Severity of Nonalcoholic Fatty Liver Disease in High-Fat/High-Fructose Diet–Fed Hamsters
Apisit Chaidee
Apisit Chaidee
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET) Working Group, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET) Working Group, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Sudarat Onsurathum
Sudarat Onsurathum
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET) Working Group, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET) Working Group, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Kitti Intuyod
Kitti Intuyod
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET) Working Group, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET) Working Group, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Ornuma Haonon
Ornuma Haonon
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET) Working Group, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET) Working Group, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Patchareewan Pannangpetch
Patchareewan Pannangpetch
Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Chatlert Pongchaiyakul
Chatlert Pongchaiyakul
Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Porntip Pinlaor
Porntip Pinlaor
Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET) Working Group, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand;
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Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand;
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Chawalit Pairojkul
Chawalit Pairojkul
Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Jariya Umka Welbat
Jariya Umka Welbat
Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Wannaporn Ittiprasert
Wannaporn Ittiprasert
Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, The George Washington University, Washington, District of Columbia
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Christina J. Cochran
Christina J. Cochran
Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, The George Washington University, Washington, District of Columbia
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Victoria H. Mann
Victoria H. Mann
Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, The George Washington University, Washington, District of Columbia
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Paul J. Brindley
Paul J. Brindley
Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, The George Washington University, Washington, District of Columbia
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Somchai Pinlaor
Somchai Pinlaor
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET) Working Group, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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Chronic Kidney Disease Prevention in The Northeast of Thailand (CKDNET) Working Group, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
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The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide, including in regions where helminth infections such as the fish-borne liver fluke Opisthorchis viverrini (Ov) also occur. We investigated the effects of a high-fat and high-fructose (HFF) diet on the development and progression of NAFLD in experimental opisthorchiasis. Two groups of hamsters were infected with Ov for 4 months before the experiment to induce chronic inflammation. One of these groups (OvHFF) was fed with a HFF diet for up to further 4 months. One uninfected group of hamsters served as the normal control group, and another received the HFF diet (HFF group) for up to 4 months. Histopathology, biochemical parameters, and ultrastructural features of liver were investigated. In a short-term treatment, the OvHFF group showed significantly better homeostatic model assessment for insulin resistance level and lower liver lipid than did the HFF group. By contrast, histopathological characteristics of severe NAFLD were prominent in the OvHFF group after 4 months on the HFF diet, findings which were supported by confirmatory ultrastructural changes. In conclusion, opisthorchiasis induced the severe NAFLD in hamsters fed high-fat/high-fructose diets.
- Supplemental Materials (MS Word 16 KB)
Author Notes
Financial support: The Thailand Research Fund (RSA5780046) (S. P.) supported this project. A. C. is a graduate student supported by the Faculty of Medicine, Khon Kaen University, Ph.D.-M.D. Program, and the Thailand Research Fund and Khon Kaen University through the Royal Golden Jubilee Ph.D. Program (grant number PHD/0011/2555) (to A. C. and S. P.) and Invitation Research Fund and Research assistant, the Faculty of Medicine, Khon Kaen University, Thailand (IN59158).
Authors’ addresses: Apisit Chaidee, Sudarat Onsurathum, Kitti Intuyod, Ornuma Haonon, and Somchai Pinlaor, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mails: apisit.chaidee@gmail.com, onsurathum.s@gmail.com, kitti.i@kkumail.com, ornuma_hao@kkumail.com, and psomec@kku.ac.th. Patchareewan Pannangpetch, Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mail: patc_pan@kku.ac.th. Chatlert Pongchaiyakul, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mail: pchatl@kku.ac.th. Porntip Pinlaor, Center for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand, E-mail: porawa@kku.ac.th. Chawalit Pairojkul, Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mail: chawalit.pjk2011@gmail.com. Jariya Umka Welbat, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mail: jariya_umka@yahoo.com. Wannaporn Ittiprasert, Christina J. Cochran, Victoria H. Mann, and Paul J. Brindley, Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, The George Washington University, Washington, DC, E-mails: wannaporni@gwu.edu, tinajcochran@hotmail.com, vmann@gwu.edu, and pbrindley@gwu.edu.
- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- Opisthorchiasis increases the liver-to-body weight ratio in HFF diet–fed hamsters.
- Opisthorchiasis increases IR in HFF diet–fed hamsters.
- Opisthorchiasis causes dyslipidemia during HFF diet.
- Opisthorchis viverrini infection augments the severity of NAFLD in HFF diet–fed hamsters.
- Opisthorchiasis induces organelle abnormalities in hepatocytes of hamsters fed HFF diet.
- DISCUSSION
- Supplemental table appears
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Sithithaworn P, Andrews RH, Nguyen VD, Wongsaroj T, Sinuon M, Odermatt P, Nawa Y, Liang S, Brindley PJ, Sripa B, 2012. The current status of opisthorchiasis and clonorchiasis in the Mekong basin. Parasitol Int 61: 10–16.
-
2.
Jittimanee J, Sermswan RW, Puapairoj A, Maleewong W, Wongratanacheewin S, 2007. Cytokine expression in hamsters experimentally infected with Opisthorchis viverrini. Parasite Immunol 29: 159–167.
-
3.
Prakobwong S, Pinlaor S, Yongvanit P, Sithithaworn P, Pairojkul C, Hiraku Y, 2009. Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagens in hamsters infected with Opisthorchis viverrini with special reference to peribiliary fibrosis and liver injury. Int J Parasitol 39: 825–835.
-
4.
Yongvanit P, Pinlaor S, Bartsch H, 2012. Oxidative and nitrative DNA damage: key events in opisthorchiasis-induced carcinogenesis. Parasitol Int 61: 130–135.
-
5.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2012. Biological agents. Volume 100 B. A review of human carcinogens. IARC Monogr Eval Carcinog Risks Hum 100: 1–441.
-
6.
Laothong U, Pinlaor P, Boonsiri P, Hiraku Y, Khoontawad J, Hongsrichan N, Charoensuk L, Pinlaor S, 2013. α-Tocopherol and lipid profiles in plasma and the expression of alpha-tocopherol-related molecules in the liver of Opisthorchis viverrini-infected hamsters. Parasitol Int 62: 127–133.
-
7.
Adam R, Hinz E, Sithithaworn P, Pipitgool V, Storch V, 1993. Ultrastructural hepatic alterations in hamsters and jirds after experimental infection with the liver fluke Opisthorchis viverrini. Parasitol Res 79: 357–364.
-
8.
Laothong U, Pinlaor P, Boonsiri P, Pairojkul C, Priprem A, Johns NP, Charoensuk L, Intuyod K, Pinlaor S, 2013. Melatonin inhibits cholangiocarcinoma and reduces liver injury in Opisthorchis viverrini-infected and N-nitrosodimethylamine-treated hamsters. J Pineal Res 55: 257–266.
-
9.
Chaidee A et al. 2018. Co-occurrence of opisthorchiasis and diabetes exacerbates morbidity of the hepatobiliary tract disease. Plos Negl Trop Dis 12: e0006611.
-
10.
Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M, Sanyal AJ; American Gastroenterological Association, American Association for the Study of Liver Diseases, American College of Gastroenterologyh, 2012. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 142: 1592–1609.
-
11.
Rinella ME, 2015. Nonalcoholic fatty liver disease: a systematic review. JAMA 313: 2263–2273.
-
12.
Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M, Landt CL, Harrison SA, 2011. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 140: 124–131.
-
13.
Birkenfeld AL, Shulman GI, 2014. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology 59: 713–723.
-
14.
Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M, 2016. Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 64: 73–84.
-
15.
Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J, Bugianesi E, 2018. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol 15: 11–20.
-
16.
Tacke F, Yoneyama H, 2013. From NAFLD to NASH to fibrosis to HCC: role of dendritic cell populations in the liver. Hepatology 58: 494–496.
-
17.
Chen Y, Yousaf MN, Mehal WZ, 2018. Role of sterile inflammation in fatty liver diseases. Liver Res 2: 21–29.
-
18.
Ganz M, Bukong TN, Csak T, Saha B, Park JK, Ambade A, Kodys K, Szabo G, 2015. Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice. J Transl Med 13: 193.
-
19.
Angulo P et al. 2015. Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology 149: 389–397 e10.
-
20.
Kanwal F et al. 2018. Risk of hepatocellular cancer in patients with non-alcoholic fatty liver disease. Gastroenterology 155: 1828–1837 e2.
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