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-
1.
Claushuis TA, 2016. Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients. Blood 127: 3062–3072.
-
2.
Vieira-de-Abreu A, Campbell RA, Weyrich AS, Zimmerman GA, 2012. Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum. Semin Immunopathol 34: 5–30.
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3.
Birnie E, Koh GCKW, Löwenberg EC, Meijers JCM, Maude RR, Day NPJ, Peacock SJ, van der Poll T, Wiersinga WJ, 2017. Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis. PLoS Negl Trop Dis 11: e0005468.
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4.
Birnie E et al. 2018. Thrombocytopenia impairs host defense against Burkholderia pseudomallei (melioidosis). J Infect Dis, doi: 10.1093/infdis/jiy541 (Epub ahead of print).
-
5.
Cheng AC, Jacups SP, Anstey NM, Currie BJ, 2003. A proposed scoring system for predicting mortality in melioidosis. Trans R Soc Trop Med Hyg 97: 577–581.
-
6.
Currie BJ, Ward L, Cheng AC, 2010. The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis 4: e900.
-
7.
Stewart JD, Smith S, Binotto E, McBride WJ, Currie BJ, Hanson J, 2017. The epidemiology and clinical features of melioidosis in Far North Queensland: implications for patient management. PLoS Negl Trop Dis 11: e0005411.
-
8.
Cheng AC, O’Brien M, Jacups SP, Anstey NM, Currie BJ, 2004. C-reactive protein in the diagnosis of melioidosis. Am J Trop Med Hyg 70: 580–582.
-
9.
Venkata C, Kashyap R, Farmer JC, Afessa B, 2013. Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome. J Intensive Care 1: 9.
-
10.
Kremer Hovinga JA, Zeerleder S, Kessler P, Romani de Wit T, van Mourik JA, Hack CE, ten Cate H, Reitsma PH, Wuillemin WA, Lämmle B, 2007. ADAMTS-13, von Willebrand factor and related parameters in severe sepsis and septic shock. J Thromb Haemost 5: 2284–2290.
-
11.
Smith S, Munas AM, Hanson J, 2018. Haemophagocytic lymphohistiocytosis complicating melioidosis. Am J Trop Med Hyg 99: 557–558.
-
12.
de Stoppelaar SF, van ’t Veer C, Claushuis TA, Albersen BJ, Roelofs JJ, van der Poll T, 2014. Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice. Blood 124: 3781–3790.
-
13.
Wiersinga WJ, Virk HS, Torres AG, Currie BJ, Peacock SJ, Dance DAB, Limmathurotsakul D, 2018. Melioidosis. Nat Rev Dis Primers 4: 17107.
| Past two years | Past Year | Past 30 Days | |
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Clinical Utility of Platelet Count as a Prognostic Marker for Melioidosis
Philippa Kirby
Philippa Kirby
Global and Tropical Health Division, Menzies School of Health Research, Darwin, Australia;
Infectious Diseases Department and Northern Territory Medical Program, Royal Darwin Hospital, Darwin, Australia;
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Infectious Diseases Department and Northern Territory Medical Program, Royal Darwin Hospital, Darwin, Australia;
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Simon Smith
Simon Smith
Department of Medicine, Cairns Hospital, Cairns, Australia;
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Linda Ward
Linda Ward
Global and Tropical Health Division, Menzies School of Health Research, Darwin, Australia;
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Josh Hanson
Josh Hanson
Global and Tropical Health Division, Menzies School of Health Research, Darwin, Australia;
Department of Medicine, Cairns Hospital, Cairns, Australia;
Kirby Institute, University of New South Wales, Kensington, Australia
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Department of Medicine, Cairns Hospital, Cairns, Australia;
Kirby Institute, University of New South Wales, Kensington, Australia
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Bart J. Currie
Bart J. Currie
Global and Tropical Health Division, Menzies School of Health Research, Darwin, Australia;
Infectious Diseases Department and Northern Territory Medical Program, Royal Darwin Hospital, Darwin, Australia;
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Infectious Diseases Department and Northern Territory Medical Program, Royal Darwin Hospital, Darwin, Australia;
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Thromobocytopenia predicts mortality in patients with melioidosis in Thailand. We analyzed platelet counts in two large cohorts of melioidosis patients in tropical northern Australia to assess utility in a different clinical setting. Admission platelet counts were compared between subgroups of patients with different clinical outcomes. Patients with more severe disease (indicated by bacteremia, septic shock, and death) had significantly lower platelet counts than those with less severe disease. Logistic regression analysis was carried out for potential predictors of mortality among various clinical parameters, and platelet count was shown to be an independent predictor of mortality. Furthermore, in patients critically ill with melioidosis, an increasing platelet count after admission was associated with a significantly greater chance of survival. However, given that most patients with severe disease still had platelet counts within the normal range, platelet count is not a useful biomarker for predicting the severity of melioidosis in a clinical context.
Author Notes
Financial support: This study was supported by grants from the Australian National Health and Medical Research Council: grant numbers 1046812, 1098337 and 1131932 (The HOT NORTH initiative).
Authors’ addresses: Philippa Kirby, Linda Ward, and Bart J. Currie, Menzies School of Health Research, Royal Darwin Hospital, Darwin, Australia, E-mails: philippa.kirby@hotmail.com, linda.ward@menzies.edu.au, and bart.currie@menzies.edu.au. Simon Smith, Department of Medicine, Cairns Hospital, Cairns, Australia, E-mail: sismith17@hotmail.com. Josh Hanson, Kirby Institute, University of New South Wales, Sydney, Australia, and General Medicine, Cairns Hospital, Cairns, Australia, E-mail: drjoshhanson@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Claushuis TA, 2016. Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients. Blood 127: 3062–3072.
-
2.
Vieira-de-Abreu A, Campbell RA, Weyrich AS, Zimmerman GA, 2012. Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum. Semin Immunopathol 34: 5–30.
-
3.
Birnie E, Koh GCKW, Löwenberg EC, Meijers JCM, Maude RR, Day NPJ, Peacock SJ, van der Poll T, Wiersinga WJ, 2017. Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis. PLoS Negl Trop Dis 11: e0005468.
-
4.
Birnie E et al. 2018. Thrombocytopenia impairs host defense against Burkholderia pseudomallei (melioidosis). J Infect Dis, doi: 10.1093/infdis/jiy541 (Epub ahead of print).
-
5.
Cheng AC, Jacups SP, Anstey NM, Currie BJ, 2003. A proposed scoring system for predicting mortality in melioidosis. Trans R Soc Trop Med Hyg 97: 577–581.
-
6.
Currie BJ, Ward L, Cheng AC, 2010. The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis 4: e900.
-
7.
Stewart JD, Smith S, Binotto E, McBride WJ, Currie BJ, Hanson J, 2017. The epidemiology and clinical features of melioidosis in Far North Queensland: implications for patient management. PLoS Negl Trop Dis 11: e0005411.
-
8.
Cheng AC, O’Brien M, Jacups SP, Anstey NM, Currie BJ, 2004. C-reactive protein in the diagnosis of melioidosis. Am J Trop Med Hyg 70: 580–582.
-
9.
Venkata C, Kashyap R, Farmer JC, Afessa B, 2013. Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome. J Intensive Care 1: 9.
-
10.
Kremer Hovinga JA, Zeerleder S, Kessler P, Romani de Wit T, van Mourik JA, Hack CE, ten Cate H, Reitsma PH, Wuillemin WA, Lämmle B, 2007. ADAMTS-13, von Willebrand factor and related parameters in severe sepsis and septic shock. J Thromb Haemost 5: 2284–2290.
-
11.
Smith S, Munas AM, Hanson J, 2018. Haemophagocytic lymphohistiocytosis complicating melioidosis. Am J Trop Med Hyg 99: 557–558.
-
12.
de Stoppelaar SF, van ’t Veer C, Claushuis TA, Albersen BJ, Roelofs JJ, van der Poll T, 2014. Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice. Blood 124: 3781–3790.
-
13.
Wiersinga WJ, Virk HS, Torres AG, Currie BJ, Peacock SJ, Dance DAB, Limmathurotsakul D, 2018. Melioidosis. Nat Rev Dis Primers 4: 17107.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 323 | 288 | 43 |
| Full Text Views | 704 | 12 | 1 |
| PDF Downloads | 185 | 14 | 1 |