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Kahloun R , Abroug N , Ksiaa I , Mahmoud A , Zeghidi H , Zaouali S , Khairallah M , 2015. Infectious optic neuropathies: a clinical update. Eye Brain 7: 59–81.
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Padhi TR , Das S , Sharma S , Rath S , Rath S , Tripathy D , Panda KG , Basu S , Besirli CG , 2017. Ocular parasitoses: a comprehensive review. Surv Ophthalmol 62: 161–189.
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Reis J , Spencer PS , Román GC , Buguet A , 2021. Environmental neurology in the tropics. J Neurol Sci 421: 117287.
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Joshi V , Agurto C , Barriga S , Nemeth S , Soliz P , MacCormick IJ , Lewallen S , Taylor TE , Harding SP , 2017. Automated detection of malarial retinopathy in digital fundus images for improved diagnosis in Malawian children with clinically defined cerebral malaria. Sci Rep 7: 42703.
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Lewallen S , Bronzan RN , Beare NA , Harding SP , Molyneux ME , Taylor TE , 2008. Using malarial retinopathy to improve the classification of children with cerebral malaria. Trans R Soc Trop Med Hyg 102: 1089–1094.
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| Past two years | Past Year | Past 30 Days | |
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Case Report: Severe Optic Neuritis after Multiple Episodes of Malaria in a Traveler to Africa
Chuan-bin Sun
Chuan-bin Sun
Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China;
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Zhiqiong Ma
Zhiqiong Ma
Department of Ophthalmology, Xiaoshan Hospital, Hangzhou, China;
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Zhe Liu
Zhe Liu
Department of Ophthalmology, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, China
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ABSTRACT.
Although local transmission of malaria has been eliminated, the disease is frequently imported to China by Chinese travelers returning from Africa. Optic neuritis (ON) is occasionally reported in malarial cases and usually shows good visual recovery and prognosis. Herein, we report severe visual loss with poor recovery due to bilateral ON in a malarial patient who traveled from Nigeria. While he was still in Nigeria, his visual acuity dropped to no light perception in both eyes after the third episode of malaria, which was confirmed by a positive blood smear for malarial parasites. His general condition gradually improved after a 6-day course of artesunate therapy. However, visual acuity in both eyes remained unchanged after artesunate therapy alone, with gradual improvement subsequently shown after pulse steroid therapy. Our case indicates that early antimalarial drugs combined with pulse steroid therapy may be of great importance for good visual recovery in ON cases after malarial infection.
Author Notes
Authors’ addresses: Chuan-bin Sun, Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, E-mail: sunshine2012@zju.edu.cn. Zhiqiong Ma, Department of Ophthalmology, Xiaoshan Hospital, Hangzhou, China, E-mail: mazhiqiong@live.com. Zhe Liu, Department of Ophthalmology, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, China, E-mail: doctorliuzhe@126.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Eggenberger ER , 2019. Infectious optic neuropathies. Continuum (Minneap Minn) 25: 1422–1437.
-
2.
Kahloun R , Abroug N , Ksiaa I , Mahmoud A , Zeghidi H , Zaouali S , Khairallah M , 2015. Infectious optic neuropathies: a clinical update. Eye Brain 7: 59–81.
-
3.
Padhi TR , Das S , Sharma S , Rath S , Rath S , Tripathy D , Panda KG , Basu S , Besirli CG , 2017. Ocular parasitoses: a comprehensive review. Surv Ophthalmol 62: 161–189.
-
4.
Reis J , Spencer PS , Román GC , Buguet A , 2021. Environmental neurology in the tropics. J Neurol Sci 421: 117287.
-
5.
Kochar DK , Shubhakaran, Kumawat BL , Thanvi I , Joshi A , Vyas SP , 1998. Ophthalmoscopic abnormalities in adults with falciparum malaria. QJM 91: 845–852.
-
6.
Maude RJ et al., 2009. The spectrum of retinopathy in adults with Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg 103: 665–671.
-
7.
Faber H , Berens P , Rohrbach JM , 2022. Ocular changes as a diagnostic tool for malaria [in German]. Ophthalmologie 119: 693–698.
-
8.
Lewallen S , Taylor TE , Molyneux ME , Wills BA , Courtright P , 1993. Ocular fundus findings in Malawian children with cerebral malaria. Ophthalmology 100: 857–861.
-
9.
Joshi V , Agurto C , Barriga S , Nemeth S , Soliz P , MacCormick IJ , Lewallen S , Taylor TE , Harding SP , 2017. Automated detection of malarial retinopathy in digital fundus images for improved diagnosis in Malawian children with clinically defined cerebral malaria. Sci Rep 7: 42703.
-
10.
Chacko JG , Onteddu S , Rosenbaum ER , 2013. Bilateral optic neuritis due to malaria. J Neuroophthalmol 33: 266–267.
-
11.
Cao S , Wang L , Wei S , 2015. Bilateral optic neuritis secondary to malaria parasite. Chin J Ocul Fundus Dis 31: 600–601.
-
12.
Wadia PZ , 1990. Retrobulbar neuritis in two patients with falciparum malaria. J Assoc Physicians India 38: 800–801.
-
13.
Kale VP , Bichile LS , Bajpai S , 2004. Falciparum malaria induced retrobulbar neuritis. J Postgrad Med 50: 150.
-
14.
Kasundra GM , Bhargava AN , Bhushan B , Shubhakaran K , Sood I , 2015. Post-Plasmodium vivax malaria cerebellar ataxia and optic neuritis: a new form of delayed cerebellar ataxia or cerebellar variant of acute disseminated encephalomyelitis? J Pediatr Neurosci 10: 58–60.
-
15.
Lewallen S , Bronzan RN , Beare NA , Harding SP , Molyneux ME , Taylor TE , 2008. Using malarial retinopathy to improve the classification of children with cerebral malaria. Trans R Soc Trop Med Hyg 102: 1089–1094.
-
16.
Choudhury H , Panchal B , Doshi S , Pathengay A , 2019. Occlusion of the central retinal artery in Plasmodium falciparum malaria. BMJ Case Rep 12: e230137.
-
17.
Flower B , Armstrong-James D , Dance C , Bremner F , Doherty T , 2011. Blind, breathless, and paralysed from benign malaria. Lancet 377: 438.
-
18.
Gallien S , Milea D , Thiebaut MM , Bricaire F , Le Hoang P , 2007. Brain and optic nerve ischemia in malaria with immune disorders. J Infect 54: e1–e3.
-
19.
Sun C , Qing X , Bai H , Xu D , Tang W , 2020. Etiology and ophthalmic characteristics of infectious and infection-related optic neuropathies. Yan Ke Xue Bao 35: 327–336.
-
20.
Neuro-ophthalmology Group of Ophthalmology Branch of Chinese Medical Association , 2022. Chinese expert consensus on the diagnosis and treatment of infiltrative optic neuropathy (2022) [in Chinese]. Chin J Ocul Fundus Dis. 38: 955–962.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1091 | 880 | 130 |
| Full Text Views | 2018 | 171 | 0 |
| PDF Downloads | 198 | 20 | 0 |