| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 583 | 357 | 80 |
| Full Text Views | 6 | 2 | 0 |
| PDF Downloads | 4 | 3 | 0 |
Lymphocytes and Eosinophils in the Immune Response of Rats to Initial and Subsequent Infections with Nippostrongylus Brasiliensis
Bridget M. Ogilvie
Bridget M. Ogilvie
Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, England
Search for other papers by Bridget M. Ogilvie in
Current site
Google Scholar
PubMed
Search for other papers by Bridget M. Ogilvie in
Current site
Google Scholar
PubMed
Charles D. Mackenzie
Charles D. Mackenzie
Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, England
Search for other papers by Charles D. Mackenzie in
Current site
Google Scholar
PubMed
Search for other papers by Charles D. Mackenzie in
Current site
Google Scholar
PubMed
Robert J. Love
Robert J. Love
Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, England
Search for other papers by Robert J. Love in
Current site
Google Scholar
PubMed
Search for other papers by Robert J. Love in
Current site
Google Scholar
PubMed
Nippostrongylus brasiliensis goes through both a tissue and a gut phase during its life cycle in the rat. It enters the body through the skin (experimentally, by subcutaneous injection) as a third stage larva. The larvae migrate rapidly to the lungs where they molt, about 30–40 h after entering the body, to the fourth larval stage. These larvae migrate up the trachea and down the esophagus to the small intestine, where they molt again (about 60–120 h after infection) to the final adult worm stage. The male and female worms do not penetrate into the mucosa but lie tightly coiled between the villi like snakes in the grass. They do not suck blood.
The rejection of Nippostrongylus brasiliensis from rats by the immune response is thought to involve several aspects of the host's immunological armory. In this report we consider the many immune responses detectable during an infection, and attempt to relate their occurrence with the fate of the parasite in primary and subsequent infections.
Author Notes
Present address: Department of Veterinary Medicine, University of Sydney, Sydney, New South Wales, Australia.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 583 | 357 | 80 |
| Full Text Views | 6 | 2 | 0 |
| PDF Downloads | 4 | 3 | 0 |