| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 22166 | 22166 | 22166 |
| Full Text Views | 104 | 104 | 104 |
| PDF Downloads | 48 | 48 | 48 |
Development of Carbapenem Resistance While on Antibiotic Therapy in a Patient with Melioidosis
Matthew Chung Yi Koh
matthew.koh@mohh.com.sg
Matthew Chung Yi Koh
Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore;
Search for other papers by Matthew Chung Yi Koh in
Current site
Google Scholar
PubMed
Search for other papers by Matthew Chung Yi Koh in
Current site
Google Scholar
PubMed
Alicia Ang
Alicia Ang
Department of Infectious Diseases, Woodlands Health, Singapore, Singapore;
Search for other papers by Alicia Ang in
Current site
Google Scholar
PubMed
Search for other papers by Alicia Ang in
Current site
Google Scholar
PubMed
Jinghao Nicholas Ngiam
Jinghao Nicholas Ngiam
Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore;
Search for other papers by Jinghao Nicholas Ngiam in
Current site
Google Scholar
PubMed
Search for other papers by Jinghao Nicholas Ngiam in
Current site
Google Scholar
PubMed
David Michael Allen
David Michael Allen
Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore;
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
Search for other papers by David Michael Allen in
Current site
Google Scholar
PubMed
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
Search for other papers by David Michael Allen in
Current site
Google Scholar
PubMed
Brenda Sze Peng Ang
Brenda Sze Peng Ang
Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore
Search for other papers by Brenda Sze Peng Ang in
Current site
Google Scholar
PubMed
Search for other papers by Brenda Sze Peng Ang in
Current site
Google Scholar
PubMed
We present a case of a 46-year-old male with disseminated melioidosis. He initially presented with primary bacteremia but eventually developed a recrudescent infection characterized by meningo-rhombencephalitis, as well as pulmonary and splenic abscesses. This was attributed to the emergence of carbapenem resistance, which developed while he was receiving parenteral antibiotic therapy. The patient eventually improved after switching his antibiotics to a combination of ceftazidime and trimethoprim-sulfamethoxazole. The development of carbapenem resistance in Burkholderia pseudomallei during therapy is rare but may be attributed to mutations resulting in the overexpression of efflux pumps. Combination therapy may play a role in such cases by limiting the emergence of antibiotic resistance.
Author Notes
Disclosures: Written informed consent was obtained from the patient prior to this report. The authors declare no conflicts of interest. Data may be made available upon reasonable request from the corresponding author.
Current contact information: Matthew Chung Yi Koh, Jinghao Nicholas Ngiam, and David Michael Allen, Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore, E-mails: matthew.koh@mohh.com.sg, nicholas_ngiam@nuhs.edu.sg, and mdcdma@nus.edu.sg. Alicia Ang, Department of Infectious Diseases, Woodlands Health, Singapore, Singapore, E-mail: alicia_xy_ang@wh.com.sg. Brenda Sze Peng Ang, Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore, E-mail: brenda_ang@ttsh.com.sg.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 22166 | 22166 | 22166 |
| Full Text Views | 104 | 104 | 104 |
| PDF Downloads | 48 | 48 | 48 |