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Migratory Soft-Tissue Swelling Owing to Subcutaneous Dirofilariasis
Chudapa Sereeaphinan
Chudapa Sereeaphinan
Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand;
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Suchanan Hanamornroongruang
Suchanan Hanamornroongruang
Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand;
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Panitta Sitthinamsuwan
Panitta Sitthinamsuwan
Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand;
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Patsharaporn T. Sarasombath
Patsharaporn T. Sarasombath
Siriraj Integrative Center for Neglected Parasitic Diseases, Department of Parasitology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
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Chuda Rujitharanawong
maichudaruji@gmail.com
Chuda Rujitharanawong
Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand;
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Dirofilariasis is an emerging zoonotic infection caused by filarial nematodes from the Dirofilaria genus, typically transmitted through mosquito bites. This case is unique because of the migratory nature of subcutaneous nodules, a presentation seldom associated with Dirofilaria infections. A 51-year-old Thai female presented with migratory subcutaneous nodules on her left arm. Initially misdiagnosed as cellulitis, she received empirical antibiotics, showing only partial improvement, and subsequently developed new nodules. A skin biopsy revealed nematode segments, and molecular identification confirmed Dirofilaria repens using polymerase chain reaction targeting the filarial mitochondrial 12s ribosomal RNA and internal transcribed spacer 1 genes. Treatment with a 3-week course of 400 mg oral albendazole resulted in complete resolution of the lesions. This case underscores the importance of molecular diagnostics when morphological identification is challenging as it enables accurate species identification, enhances disease management, and supports optimized treatment of unusual presentations of dirofilariasis.
Author Notes
Financial support: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Current contact information: Chudapa Sereeaphinan and Chuda Rujitharanawong, Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, E-mails: chudapa.se@gmail.com and maichudaruji@gmail.com. Suchanan Hanamornroongruang and Panitta Sitthinamsuwan, Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, E-mails: suchananice@hotmail.com and panitta.sit@mahidol.ac.th. Patsharaporn T. Sarasombath, Siriraj Integrative Center for Neglected Parasitic Diseases, Department of Parasitology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, E-mail: p.techasintana@gmail.com.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 98 | 98 | 98 |
| Full Text Views | 16 | 16 | 16 |
| PDF Downloads | 2 | 2 | 2 |