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Serotypes and Antimicrobial Resistance Patterns of Invasive Non-Typhoidal Salmonella in Uganda
John Bosco Kalule
kaluleb@gmail.com
John Bosco Kalule
Department of Biotechnical and Diagnostic Sciences (BDS), College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, Kampala, Uganda;
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Valeria Nakintu Zalwango
Valeria Nakintu Zalwango
Department of Biotechnical and Diagnostic Sciences (BDS), College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, Kampala, Uganda;
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Pauline Kyazike
Pauline Kyazike
Department of Biotechnical and Diagnostic Sciences (BDS), College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, Kampala, Uganda;
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Samuel Majalija
Samuel Majalija
National Livestock Resources Research Institute (NALIRRI), National Agricultural Research Organization (NARO), Namulonge, Uganda
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Drug-resistant invasive non-typhoidal Salmonella poses a significant challenge to the management of acute febrile illnesses in Uganda. However, the characteristics of invasive non-typhoidal Salmonella strains are not yet well understood. This study aimed to determine the serotypes and antimicrobial resistance patterns of invasive non-typhoidal Salmonella isolates from a local health center in Uganda. Invasive non-typhoidal Salmonella isolates archived over 5 years from febrile patients at a local health center were characterized for serotypes and antimicrobial susceptibility patterns using conventional methods. Among the 80 archived isolates, 18 serotypes of invasive non-typhoidal Salmonella were identified, with Salmonella Typhimurium (42.5%), Salmonella Enteritidis (20%), and Salmonella Haifa (8.8%) being the most prevalent. A total of 81.3% (65/80) of the isolates exhibited resistance to at least one antibiotic, with the highest resistance rates observed for streptomycin (72.5%), trimethoprim-sulfamethoxazole (66.2%), and ampicillin (56.2%). The most common antimicrobial resistance profile, found in 23.1% (15/65) of resistant isolates, was Amp-C-S10-S300-SXT. Notably, 81.5% of the drug-resistant isolates were multi-drug resistant. Invasive non-typhoidal Salmonella in this setting have a high rate of antimicrobial resistance to commonly used antibiotics. Improved treatment guidelines could be adapted for better clinical outcomes.
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Author Notes
Financial support: The research activities were facilitated by
Disclosure: Ethical clearance was obtained from the research and ethics committee of the School of Biomedical, Biotechnical and Laboratory Sciences, Makerere University (HREC 088/2024).
Current contact information: John Bosco Kalule, Valeria Nakintu Zalwango, and Pauline Kyazike, Department of Biotechnical and Diagnostic Sciences, College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, Kampala, Uganda, E-mails: kaluleb@gmail.com, valerianakintu3@gmail.com, and kyazikepauline@gmail.com. Samuel Majalija, National Livestock Resources Research Institute (NALIRRI), National Agricultural Research Organization (NARO), Namulonge, Uganda, E-mail: saraali67@gmail.com.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 125 | 125 | 125 |
| Full Text Views | 4 | 4 | 4 |
| PDF Downloads | 4 | 4 | 4 |