| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 192 | 192 | 192 |
| Full Text Views | 2 | 2 | 2 |
| PDF Downloads | 3 | 3 | 3 |
Uropathogens and Their Antimicrobial Resistance Profile at a Pediatric Tertiary Care Hospital in Kathmandu, Nepal
Sohani Bajracharya
Sohani Bajracharya
Department of Microbiology, Kanti Children’s Hospital, Kathmandu, Nepal;
Search for other papers by Sohani Bajracharya in
Current site
Google Scholar
PubMed
Search for other papers by Sohani Bajracharya in
Current site
Google Scholar
PubMed
Ajaya Basnet
abasnet.microberesearch@gmail.com
Ajaya Basnet
Department of Microbiology, Nepal Armed Police Force Hospital, Kathmandu, Nepal;
Search for other papers by Ajaya Basnet in
Current site
Google Scholar
PubMed
Search for other papers by Ajaya Basnet in
Current site
Google Scholar
PubMed
Nayanum Pokhrel
Nayanum Pokhrel
Research Section, Nepal Health Research Council, Kathmandu, Nepal;
Search for other papers by Nayanum Pokhrel in
Current site
Google Scholar
PubMed
Search for other papers by Nayanum Pokhrel in
Current site
Google Scholar
PubMed
Aashish Gupta
Aashish Gupta
Department of Microbiology, Nepal Police Hospital, Kathmandu, Nepal;
Search for other papers by Aashish Gupta in
Current site
Google Scholar
PubMed
Search for other papers by Aashish Gupta in
Current site
Google Scholar
PubMed
Laxmi Kant Khanal
Laxmi Kant Khanal
Department of Microbiology, Nepal Medical College Teaching Hospital, Kathmandu, Nepal
Search for other papers by Laxmi Kant Khanal in
Current site
Google Scholar
PubMed
Search for other papers by Laxmi Kant Khanal in
Current site
Google Scholar
PubMed
Urinary tract infections (UTIs) are treated based on local antimicrobial susceptibility patterns; however, growing antimicrobial resistance necessitates continuous monitoring. This retrospective study examined the prevalence of pediatric UTIs, identified causative pathogens, and evaluated their antibiograms and resistance patterns. We examined the demographic data, microbiological profiles, and antimicrobial susceptibility results (September 2019–August 2021) of pediatric patients (neonates to 14 years) with positive urine culture results at Kanti Children’s Hospital, Kathmandu, Nepal, using SPSS version 17.0 (IBM Corp., Armonk, NY). Among 8,072 urine specimens, 575 (7.1%) (95% CI: 6.6–7.7) tested positive for significant infections, primarily from outpatients (88.2%) and males (54.1%), with a median age of 2 years. Most UTIs (93.0%; 535/575) were caused by bacteria, primarily Escherichia coli (78.5%; 420/535). Cumulative resistance rates were 92.4% for penicillin, 69.3% for cephalosporins, 39.7% for quinolones, 30.2% for carbapenems, and 14.3% for aminoglycosides. One hundred sixty-eight (40.0%) E. coli strains and four (33.3%) Pseudomonas aeruginosa strains were multidrug-resistant. Seven (9.0%) Klebsiella pneumoniae strains were extensively drug-resistant (XDR), and 15 (21.1%) were extended-spectrum β-lactamase (ESBL) producers. Multidrug-resistant strains (36.5%; 210/575), XDR strains (22.6%; 15/575), and ESBL producers (14.4%; 83/575) showed >70.0% resistance to ampicillin, cefotaxime-clavulanate, and cefixime. Over the years, resistance to β-lactams has risen, whereas resistance to aminoglycosides, carbapenems, and cotrimoxazole has decreased. Resistance to quinolones has remained consistent. Pediatric UTIs were least common in this hospital, with the majority caused by E. coli. Multidrug-resistant bacteria were more prevalent than XDR and ESBL-producing bacteria. Although resistance to β-lactam antibiotics increased over the years, resistance to aminoglycosides, carbapenems, and cotrimoxazole declined.
- Supplemental Materials (PDF 545.04 KB)
Author Notes
Disclosure: This study was approved by the Institutional Review Committee of Kanti Children’s Hospital (reference number 1289), which waived the informed consent requirement because of its retrospective nature.
Current contact information: Sohani Bajracharya, Department of Microbiology, Pokhara Academy of Health Sciences, Pokhara, Nepal, E-mail: bjr.sohani@gmail.com. Ajaya Basnet, Department of Microbiology, Nepal Armed Police Force Hospital, Kathmandu, Nepal, E-mail: abasnet.microberesearch@gmail.com. Nayanum Pokhrel, Research Section, Nepal Health Research Council, Kathmandu, Nepal, E-mail: nayanumpr@gmail.com. Aashish Gupta, Department of Microbiology, Nepal Police Hospital, Kathmandu, Nepal, E-mail: aguptamicrobiologist@yahoo.com. Laxmi Kant Khanal, Department of Microbiology, Nepal Medical College Teaching Hospital, Kathmandu, Nepal, E-mail: khanallk2017@gmail.com.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 192 | 192 | 192 |
| Full Text Views | 2 | 2 | 2 |
| PDF Downloads | 3 | 3 | 3 |