Article Category:
Case Report

Chagas Meningoencephalitis Diagnosed in Heart Transplant Patient Using Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid

Jill Teitelbaum Albert Einstein College of Medicine, Bronx, New York;

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Shivank Madan Albert Einstein College of Medicine, Bronx, New York;
Montefiore Medical Center, Bronx, New York;

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Snehal Patel Albert Einstein College of Medicine, Bronx, New York;
Montefiore Medical Center, Bronx, New York;

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Christina Coyle Albert Einstein College of Medicine, Bronx, New York;

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Charles Y. Chiu Department of Laboratory Medicine and UCSF Clinical Microbiology Laboratory, University of California San Francisco, San Francisco, California

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Phyu M. Thwe Albert Einstein College of Medicine, Bronx, New York;
Montefiore Medical Center, Bronx, New York;

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Mayuko Uehara Montefiore Medical Center, Bronx, New York;

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Rita Jermyn Montefiore Medical Center, Bronx, New York;

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Vagish Hemmige Albert Einstein College of Medicine, Bronx, New York;
Montefiore Medical Center, Bronx, New York;

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DOI:
https://doi.org/10.4269/ajtmh.24-0553
Volume/Issue:
Ahead of Print
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Chagas meningoencephalitis can present in immunocompromised patients after organ transplantation. We present the first reported instance in which metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid diagnosed Chagas meningoencephalitis in a patient. The diagnosis of Chagas in this case underscores the role of mNGS in identifying rare or unexpected pathogens.

Author Notes

Disclosures: C. Y. Chiu is a co-founder of Delve Bio and serves on the scientific advisory boards for Delve Bio, Flightpath Biosciences, Biomeme, Mammoth Biosciences, BiomeSense, and Poppy Health. C. Y. Chiu receives research support from Delve Bio and Abbott Laboratories, Inc. V. Hemmige received funding from Merck for a pneumococcal vaccine study. Informed consent was obtained from the patient.

Current contact information: Jill Teitelbaum, Christina Coyle, and Phyu M. Thwe, Albert Einstein College of Medicine, Bronx, NY, E-mails: jill.teitelbaum@einsteinmed.edu, christina.coyle@einsteinmed.edu, and pthwe@montefiore.org. Shivank Madan, Snehal Patel, Mayuko Uehara, Rita Jermyn, and Vagish Hemmige, Montefiore Medical Center, Bronx, NY, E-mails: smadan@montefiore.org, snepatel@montefiore.org, muehara@montefiore.org, rjermyn@montefiore.org, and vahemmig@montefiore.org. Charles Y. Chiu, Department of Laboratory Medicine and UCSF Clinical Microbiology Laboratory, University of California San Francisco, San Francisco, CA, E-mail: charles.chiu@ucsf.edu.

Address correspondence to Vagish Hemmige, Montefiore Medical Center, 1300 Morris Park Ave., Bronx, NY 10461. E-mail: vahemmig@montefiore.org
Copyright:
© American Society of Tropical Medicine and Hygiene 2025
Received:
20 Aug 2024
|
Accepted:
30 Jan 2025
|
Published Online:
06 May 2025
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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