Author:
- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- Diminished levels of adiponectin and leptin and elevated levels of resistin in PTB.
- Adipokine levels in PTB do not reflect disease extent or severity.
- Adipokine levels in PTB do not reflect bacterial burdens, but adiponectin exhibits a negative relationship with BMI.
- Effect of ATT on adipokine levels in PTB.
- DISCUSSION
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Tilg H, Moschen AR, 2006. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6: 772–783.
-
2.
Wellen KE, Hotamisligil GS, 2005. Inflammation, stress, and diabetes. J Clin Invest 115: 1111–1119.
-
3.
Calle EE, Kaaks R, 2004. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4: 579–591.
-
4.
La Cava A, Matarese G, 2004. The weight of leptin in immunity. Nat Rev Immunol 4: 371–379.
-
5.
Kusminski CM, McTernan PG, Kumar S, 2005. Role of resistin in obesity, insulin resistance and type II diabetes. Clin Sci (Lond) 109: 243–256.
-
6.
Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel RL, Ferrante AW Jr., 2006. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116: 115–124.
-
7.
Shehzad A, Iqbal W, Shehzad O, Lee YS, 2012. Adiponectin: regulation of its production and its role in human diseases. Hormones (Athens) 11: 8–20.
-
8.
Cheng X, Folco EJ, Shimizu K, Libby P, 2012. Adiponectin induces pro-inflammatory programs in human macrophages and CD4+ T cells. J Biol Chem 287: 36896–36904.
-
9.
Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A, 2005. Resistin, an adipokine with potent proinflammatory properties. J Immunol 174: 5789–5795.
-
10.
Wiedmer P, Nogueiras R, Broglio F, D’Alessio D, Tschop MH, 2007. Ghrelin, obesity and diabetes. Nat Clin Pract Endocrinol Metab 3: 705–712.
-
11.
Leite-Moreira AF, Soares JB, 2007. Physiological, pathological and potential therapeutic roles of ghrelin. Drug Discov Today 12: 276–288.
-
12.
Fernandez-Riejos P, Najib S, Santos-Alvarez J, Martin-Romero C, Perez-Perez A, Gonzalez-Yanes C, Sanchez-Margalet V, 2010. Role of leptin in the activation of immune cells. Mediators Inflamm 2010: 568343.
-
13.
Kim JH, Lee CT, Yoon HI, Song J, Shin WG, Lee JH, 2010. Relation of ghrelin, leptin and inflammatory markers to nutritional status in active pulmonary tuberculosis. Clin Nutr 29: 512–518.
-
14.
van Crevel R, Karyadi E, Netea MG, Verhoef H, Nelwan RH, West CE, van der Meer JW, 2002. Decreased plasma leptin concentrations in tuberculosis patients are associated with wasting and inflammation. J Clin Endocrinol Metab 87: 758–763.
-
15.
Keicho N, Matsushita I, Tanaka T, Shimbo T, Hang NT, Sakurada S, Kobayashi N, Hijikata M, Thuong PH, Lien LT, 2012. Circulating levels of adiponectin, leptin, fetuin-A and retinol-binding protein in patients with tuberculosis: markers of metabolism and inflammation. PLoS One 7: e38703.
-
16.
Ehtesham NZ, Nasiruddin M, Alvi A, Kumar BK, Ahmed N, Peri S, Murthy KJ, Hasnain SE, 2011. Treatment end point determinants for pulmonary tuberculosis: human resistin as a surrogate biomarker. Tuberculosis (Edinb) 91: 293–299.
-
17.
Deepa M, Pradeepa R, Rema M, Mohan A, Deepa R, Shanthirani S, Mohan V, 2003. The Chennai Urban Rural Epidemiology Study (CURES)–study design and methodology (urban component) (CURES-I). J Assoc Physicians India 51: 863–870.
-
18.
Makki K, Froguel P, Wolowczuk I, 2013. Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. ISRN Inflamm 2013: 139239.
-
19.
Tsang JY, Li D, Ho D, Peng J, Xu A, Lamb J, Chen Y, Tam PK, 2011. Novel immunomodulatory effects of adiponectin on dendritic cell functions. Int Immunopharmacol 11: 604–609.
-
20.
Santucci N, D’Attilio L, Kovalevski L, Bozza V, Besedovsky H, del Rey A, Bay ML, Bottasso O, 2011. A multifaceted analysis of immune-endocrine-metabolic alterations in patients with pulmonary tuberculosis. PLoS One 6: e26363.
-
21.
Chang SW, Pan WS, Lozano Beltran D, Oleyda Baldelomar L, Solano MA, Tuero I, Friedland JS, Torrico F, Gilman RH, 2013. Gut hormones, appetite suppression and cachexia in patients with pulmonary TB. PLoS One 8: e54564.
-
22.
Pan L et al. 2017. Genome-wide transcriptional profiling identifies potential signatures in discriminating active tuberculosis from latent infection. Oncotarget 8: 112907–112916.
-
23.
van Lettow M, van der Meer JW, West CE, van Crevel R, Semba RD, 2005. Interleukin-6 and human immunodeficiency virus load, but not plasma leptin concentration, predict anorexia and wasting in adults with pulmonary tuberculosis in Malawi. J Clin Endocrinol Metab 90: 4771–4776.
-
24.
Yurt S, Erman H, Korkmaz GG, Kosar AF, Uysal P, Gelisgen R, Simsek G, Uzun H, 2013. The role of feed regulating peptides on weight loss in patients with pulmonary tuberculosis. Clin Biochem 46: 40–44.
-
25.
Wieland CW, Florquin S, Chan ED, Leemans JC, Weijer S, Verbon A, Fantuzzi G, van der Poll T, 2005. Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice. Int Immunol 17: 1399–1408.
-
26.
Perna V, Perez-Perez A, Fernandez-Riejos P, Polo-Padillo J, Batista N, Dominguez-Castellano A, Sanchez-Margalet V, 2013. Effective treatment of pulmonary tuberculosis restores plasma leptin levels. Eur Cytokine Netw 24: 157–161.
-
27.
Yuksel I, Sencan M, Dokmetas HS, Dokmetas I, Ataseven H, Yonem O, 2003. The relation between serum leptin levels and body fat mass in patients with active lung tuberculosis. Endocr Res 29: 257–264.
-
28.
Mexitalia M, Dewi YO, Pramono A, Anam MS, 2017. Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children. Korean J Pediatr 60: 118–123.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1034 | 922 | 87 |
| Full Text Views | 473 | 8 | 2 |
| PDF Downloads | 144 | 12 | 2 |
Altered Systemic Adipokine Levels in Pulmonary Tuberculosis and Changes following Treatment
Kadar Moideen
Kadar Moideen
National Institutes of Health—International Center for Excellence in Research, Chennai, India;
National Institute for Research in Tuberculosis, Chennai, India;
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National Institute for Research in Tuberculosis, Chennai, India;
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Nathella Pavan Kumar
Nathella Pavan Kumar
National Institutes of Health—International Center for Excellence in Research, Chennai, India;
National Institute for Research in Tuberculosis, Chennai, India;
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National Institute for Research in Tuberculosis, Chennai, India;
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Dina Nair
Dina Nair
National Institute for Research in Tuberculosis, Chennai, India;
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Vaithilingam V. Banurekha
Vaithilingam V. Banurekha
National Institute for Research in Tuberculosis, Chennai, India;
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Subash Babu
Subash Babu
National Institutes of Health—International Center for Excellence in Research, Chennai, India;
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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Pulmonary tuberculosis (PTB) is associated with modulation of levels of adipokines, specifically adiponectin and leptin, but the effect of standard antituberculosis treatment (ATT) on the systemic levels of adiponectin, resistin, and leptin has not been well explored. To identify the association of adipokines with PTB and their relationship with disease severity and bacterial burden, we measured the levels of adiponectin, resistin, and leptin in PTB individuals and compared them with latent tuberculosis (LTB) and healthy control (HC) individuals. Pulmonary tuberculosis was characterized by diminished circulating levels of adiponectin and leptin and heightened circulating levels of resistin in comparison to that in LTB and HC individuals. However, PTB with bilateral or cavitary disease did not exhibit any increased systemic levels of these adipokines in comparison with those with unilateral or non-cavitary disease, respectively. In addition, none of the adipokines exhibited a positive correlation with bacterial burdens, but adiponectin alone exhibited a negative correlation with body mass index in PTB individuals. Finally, on successful completion of ATT, PTB individuals exhibited significantly increased levels of adiponectin and leptin and significantly decreased levels of resistin. Therefore, our data identify an important association of systemic adipokine levels with PTB disease and its alteration following ATT.
Author Notes
Financial support: This work was funded by the Division of Intramural Research, NIAID, NIH.
Authors’ addresses: Kadar Moideen, Nathella Pavan Kumar, and Subash Babu, National Institutes of Health-National Institute for Research in Tuberculosis-International Center for Excellence in Research, International Center for Excellence in Research, Chennai, India, E-mails: kadar.m@nirt.res.in, pavankumarn@nirt.res.in, and sbabu@niaid.nih.gov. Dina Nair and Vaithilingam V. Banurekha, National Institute for Research in Tuberculosis, Clinical Research, Chennai, India, E-mails: dinanair@nirt.res.in and banurekha@nirt.res.in.
- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- Diminished levels of adiponectin and leptin and elevated levels of resistin in PTB.
- Adipokine levels in PTB do not reflect disease extent or severity.
- Adipokine levels in PTB do not reflect bacterial burdens, but adiponectin exhibits a negative relationship with BMI.
- Effect of ATT on adipokine levels in PTB.
- DISCUSSION
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Tilg H, Moschen AR, 2006. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6: 772–783.
-
2.
Wellen KE, Hotamisligil GS, 2005. Inflammation, stress, and diabetes. J Clin Invest 115: 1111–1119.
-
3.
Calle EE, Kaaks R, 2004. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4: 579–591.
-
4.
La Cava A, Matarese G, 2004. The weight of leptin in immunity. Nat Rev Immunol 4: 371–379.
-
5.
Kusminski CM, McTernan PG, Kumar S, 2005. Role of resistin in obesity, insulin resistance and type II diabetes. Clin Sci (Lond) 109: 243–256.
-
6.
Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel RL, Ferrante AW Jr., 2006. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116: 115–124.
-
7.
Shehzad A, Iqbal W, Shehzad O, Lee YS, 2012. Adiponectin: regulation of its production and its role in human diseases. Hormones (Athens) 11: 8–20.
-
8.
Cheng X, Folco EJ, Shimizu K, Libby P, 2012. Adiponectin induces pro-inflammatory programs in human macrophages and CD4+ T cells. J Biol Chem 287: 36896–36904.
-
9.
Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A, 2005. Resistin, an adipokine with potent proinflammatory properties. J Immunol 174: 5789–5795.
-
10.
Wiedmer P, Nogueiras R, Broglio F, D’Alessio D, Tschop MH, 2007. Ghrelin, obesity and diabetes. Nat Clin Pract Endocrinol Metab 3: 705–712.
-
11.
Leite-Moreira AF, Soares JB, 2007. Physiological, pathological and potential therapeutic roles of ghrelin. Drug Discov Today 12: 276–288.
-
12.
Fernandez-Riejos P, Najib S, Santos-Alvarez J, Martin-Romero C, Perez-Perez A, Gonzalez-Yanes C, Sanchez-Margalet V, 2010. Role of leptin in the activation of immune cells. Mediators Inflamm 2010: 568343.
-
13.
Kim JH, Lee CT, Yoon HI, Song J, Shin WG, Lee JH, 2010. Relation of ghrelin, leptin and inflammatory markers to nutritional status in active pulmonary tuberculosis. Clin Nutr 29: 512–518.
-
14.
van Crevel R, Karyadi E, Netea MG, Verhoef H, Nelwan RH, West CE, van der Meer JW, 2002. Decreased plasma leptin concentrations in tuberculosis patients are associated with wasting and inflammation. J Clin Endocrinol Metab 87: 758–763.
-
15.
Keicho N, Matsushita I, Tanaka T, Shimbo T, Hang NT, Sakurada S, Kobayashi N, Hijikata M, Thuong PH, Lien LT, 2012. Circulating levels of adiponectin, leptin, fetuin-A and retinol-binding protein in patients with tuberculosis: markers of metabolism and inflammation. PLoS One 7: e38703.
-
16.
Ehtesham NZ, Nasiruddin M, Alvi A, Kumar BK, Ahmed N, Peri S, Murthy KJ, Hasnain SE, 2011. Treatment end point determinants for pulmonary tuberculosis: human resistin as a surrogate biomarker. Tuberculosis (Edinb) 91: 293–299.
-
17.
Deepa M, Pradeepa R, Rema M, Mohan A, Deepa R, Shanthirani S, Mohan V, 2003. The Chennai Urban Rural Epidemiology Study (CURES)–study design and methodology (urban component) (CURES-I). J Assoc Physicians India 51: 863–870.
-
18.
Makki K, Froguel P, Wolowczuk I, 2013. Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. ISRN Inflamm 2013: 139239.
-
19.
Tsang JY, Li D, Ho D, Peng J, Xu A, Lamb J, Chen Y, Tam PK, 2011. Novel immunomodulatory effects of adiponectin on dendritic cell functions. Int Immunopharmacol 11: 604–609.
-
20.
Santucci N, D’Attilio L, Kovalevski L, Bozza V, Besedovsky H, del Rey A, Bay ML, Bottasso O, 2011. A multifaceted analysis of immune-endocrine-metabolic alterations in patients with pulmonary tuberculosis. PLoS One 6: e26363.
-
21.
Chang SW, Pan WS, Lozano Beltran D, Oleyda Baldelomar L, Solano MA, Tuero I, Friedland JS, Torrico F, Gilman RH, 2013. Gut hormones, appetite suppression and cachexia in patients with pulmonary TB. PLoS One 8: e54564.
-
22.
Pan L et al. 2017. Genome-wide transcriptional profiling identifies potential signatures in discriminating active tuberculosis from latent infection. Oncotarget 8: 112907–112916.
-
23.
van Lettow M, van der Meer JW, West CE, van Crevel R, Semba RD, 2005. Interleukin-6 and human immunodeficiency virus load, but not plasma leptin concentration, predict anorexia and wasting in adults with pulmonary tuberculosis in Malawi. J Clin Endocrinol Metab 90: 4771–4776.
-
24.
Yurt S, Erman H, Korkmaz GG, Kosar AF, Uysal P, Gelisgen R, Simsek G, Uzun H, 2013. The role of feed regulating peptides on weight loss in patients with pulmonary tuberculosis. Clin Biochem 46: 40–44.
-
25.
Wieland CW, Florquin S, Chan ED, Leemans JC, Weijer S, Verbon A, Fantuzzi G, van der Poll T, 2005. Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice. Int Immunol 17: 1399–1408.
-
26.
Perna V, Perez-Perez A, Fernandez-Riejos P, Polo-Padillo J, Batista N, Dominguez-Castellano A, Sanchez-Margalet V, 2013. Effective treatment of pulmonary tuberculosis restores plasma leptin levels. Eur Cytokine Netw 24: 157–161.
-
27.
Yuksel I, Sencan M, Dokmetas HS, Dokmetas I, Ataseven H, Yonem O, 2003. The relation between serum leptin levels and body fat mass in patients with active lung tuberculosis. Endocr Res 29: 257–264.
-
28.
Mexitalia M, Dewi YO, Pramono A, Anam MS, 2017. Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children. Korean J Pediatr 60: 118–123.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1034 | 922 | 87 |
| Full Text Views | 473 | 8 | 2 |
| PDF Downloads | 144 | 12 | 2 |