ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Pukkila-Worley R, Mylonakis E, 2008. Epidemiology and management of cryptococcal meningitis: developments and challenges. Expert Opin Pharmacother 9: 551–560.
-
2.
Pappas PG, 2013. Cryptococcal infections in non-HIV-infected patients. Trans Am Clin Climatol Assoc 124: 61–79.
-
3.
Petrou P, Moscovici S, Leker RR, Itshayek E, Gomori JM, Cohen JE, 2012. Ventriculoperitoneal shunt for intracranial hypertension in cryptococcal meningitis without hydrocephalus. J Clin Neurosci 19: 1175–1176.
-
4.
Luo FL, Tao YH, Wang YM, Li H, 2015. Clinical study of 23 pediatric patients with cryptococcosis. Eur Rev Med Pharmacol Sci 19: 3801–3810.
-
5.
Tunlayadechanont S, Viranuvatti K, Phuapradit P, Sathapatayavong B, Tantirittisak T, Boongird P, 1997. Cryptococcal meningitis in patients with non-HIV and HIV infection: a clinical study. Neurol J Southeast Asia 2: 45–50.
-
6.
Wang H, Ling C, Chen C, He HY, Luo L, Ning XJ, 2014. Evaluation of ventriculoperitoneal shunt in the treatment of intracranial hypertension in the patients with cryptococcal meningitis: a report of 12 cases. Clin Neurol Neurosurg 124: 156–160.
-
7.
Dincer A, Ozek MM, 2011. Radiologic evaluation of pediatric hydrocephalus. Childs Nerv Syst 27: 1543–1562.
-
8.
Pople IK, 2002. Hydrocephalus and shunts: what the neurologist should know. J Neurol Neurosurg Psychiatry 73 (Suppl 1): i17–i22.
-
9.
Cherian J, Atmar RL, Gopinath SP, 2016. Shunting in cryptococcal meningitis. J Neurosurg 125: 177–186.
-
10.
Denning DW, Armstrong RW, Lewis BH, Stevens DA, 1991. Elevated cerebrospinal fluid pressures in patients with cryptococcal meningitis and acquired immunodeficiency syndrome. Am J Med 91: 267–272.
-
11.
Bicanic T, et al. 2009. Relationship of cerebrospinal fluid pressure, fungal burden and outcome in patients with cryptococcal meningitis undergoing serial lumbar punctures. AIDS 23: 701–706.
-
12.
Perfect JR, et al. 2010. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of America. Clin Infect Dis 50: 291–322.
-
13.
Woodworth GF, McGirt MJ, Williams MA, Rigamonti D, 2005. The use of ventriculoperitoneal shunts for uncontrollable intracranial hypertension without ventriculomegally secondary to HIV-associated cryptococcal meningitis. Surg Neurol 63: 529–531.
-
14.
Liliang PC, et al. 2003. Shunt surgery for hydrocephalus complicating cryptococcal meningitis in human immunodeficiency virus negative patients. Clin Infect Dis 37: 673–678.
-
15.
Richardson PM, Mohandas A, Arumugasamy N, 1976. Cerebral cryptococcosis in Malaysia. J Neurol Neurosurg Psychiatry 39: 330–337.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 322 | 279 | 34 |
| Full Text Views | 347 | 19 | 1 |
| PDF Downloads | 128 | 13 | 1 |
Predictive Model for Permanent Shunting in Cryptococcal meningitis
Woralux Phusoongnern
Woralux Phusoongnern
Division of Neurosurgery, Department of Surgery, Khon Kaen University, Khon Kaen, Thailand;
Search for other papers by Woralux Phusoongnern in
Current site
Google Scholar
PubMed
Search for other papers by Woralux Phusoongnern in
Current site
Google Scholar
PubMed
Siriluck Anunnatsiri
Siriluck Anunnatsiri
Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand;
Search for other papers by Siriluck Anunnatsiri in
Current site
Google Scholar
PubMed
Search for other papers by Siriluck Anunnatsiri in
Current site
Google Scholar
PubMed
Kittisak Sawanyawisuth
Kittisak Sawanyawisuth
Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand;
Research Center in Back, Neck Other Joint Pain and Human Performance (BNOJPH), Khon Kaen University, Khon Kaen, Thailand;
Non-communicable Diseases Research Group, Khon Kaen University, Khon Kaen, Thailand
Search for other papers by Kittisak Sawanyawisuth in
Current site
Google Scholar
PubMed
Research Center in Back, Neck Other Joint Pain and Human Performance (BNOJPH), Khon Kaen University, Khon Kaen, Thailand;
Non-communicable Diseases Research Group, Khon Kaen University, Khon Kaen, Thailand
Search for other papers by Kittisak Sawanyawisuth in
Current site
Google Scholar
PubMed
Amnat Kitkhuandee
Amnat Kitkhuandee
Division of Neurosurgery, Department of Surgery, Khon Kaen University, Khon Kaen, Thailand;
Search for other papers by Amnat Kitkhuandee in
Current site
Google Scholar
PubMed
Search for other papers by Amnat Kitkhuandee in
Current site
Google Scholar
PubMed
Cryptococcal meningitis may have long-term morbidity and requires a permanent cerebrospinal fluid shunt. This study aimed to evaluate the risk factors and create a predictive model for permanent shunt treatment in cryptococcal meningitis patients. This was a retrospective analytical study conducted at Khon Kaen University. The study period was from January 2005 to December 2015. We enrolled all adult patients diagnosed with cryptococcal meningitis. Risk factors predictive for permanent shunting treatment were analyzed by multivariate logistic regression analysis. There were 341 patients diagnosed with cryptococcal meningitis. Of those, 64 patients (18.7%) were treated with permanent shunts. There were three independent factors associated with permanent shunt treatment. The presence of hydrocephalus had the highest adjusted odds ratio at 56.77. The resulting predictive model for permanent shunt treatment (y) is (−3.85) + (4.04 × hydrocephalus) + (2.13 × initial cerebrospinal fluid (CSF) opening pressure (OP) > 25 cm H2O) + (1.87 × non-human immune deficiency vrus (HIV)). In conclusion, non-HIV status, initial CSF OP greater than or equal to 25 cm H2O, and the presence of hydrocephalus are indicators of the future necessity for permanent shunt therapy.
Author Notes
Authors’ addresses: Woralux Phusoongnern and Amnat Kitkhuandee, Khon Kaen University Faculty of Medicine, Surgery, Khon Kaen, Thailand, E-mails: woraluxgee@gmail.com and amnaki@kku.ac.th. Siriluck Anunnatsiri, Faculty of Medicine, Khon Kaen University, Medicine, Khon Kaen, Thailand, E-mail: asiril@kku.ac.th. Kittisak Sawanyawisuth, Khon Kaen University, Research Center in Back, Neck Other Joint Pain and Human performance (BNOJPH), Khon Kaen University Faculty of Medicine, Surgery, and Sleep Apnea Research Group, Khon Kaen University, Khon Kaen, Thailand, E-mail: kittisak@kku.ac.th.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Pukkila-Worley R, Mylonakis E, 2008. Epidemiology and management of cryptococcal meningitis: developments and challenges. Expert Opin Pharmacother 9: 551–560.
-
2.
Pappas PG, 2013. Cryptococcal infections in non-HIV-infected patients. Trans Am Clin Climatol Assoc 124: 61–79.
-
3.
Petrou P, Moscovici S, Leker RR, Itshayek E, Gomori JM, Cohen JE, 2012. Ventriculoperitoneal shunt for intracranial hypertension in cryptococcal meningitis without hydrocephalus. J Clin Neurosci 19: 1175–1176.
-
4.
Luo FL, Tao YH, Wang YM, Li H, 2015. Clinical study of 23 pediatric patients with cryptococcosis. Eur Rev Med Pharmacol Sci 19: 3801–3810.
-
5.
Tunlayadechanont S, Viranuvatti K, Phuapradit P, Sathapatayavong B, Tantirittisak T, Boongird P, 1997. Cryptococcal meningitis in patients with non-HIV and HIV infection: a clinical study. Neurol J Southeast Asia 2: 45–50.
-
6.
Wang H, Ling C, Chen C, He HY, Luo L, Ning XJ, 2014. Evaluation of ventriculoperitoneal shunt in the treatment of intracranial hypertension in the patients with cryptococcal meningitis: a report of 12 cases. Clin Neurol Neurosurg 124: 156–160.
-
7.
Dincer A, Ozek MM, 2011. Radiologic evaluation of pediatric hydrocephalus. Childs Nerv Syst 27: 1543–1562.
-
8.
Pople IK, 2002. Hydrocephalus and shunts: what the neurologist should know. J Neurol Neurosurg Psychiatry 73 (Suppl 1): i17–i22.
-
9.
Cherian J, Atmar RL, Gopinath SP, 2016. Shunting in cryptococcal meningitis. J Neurosurg 125: 177–186.
-
10.
Denning DW, Armstrong RW, Lewis BH, Stevens DA, 1991. Elevated cerebrospinal fluid pressures in patients with cryptococcal meningitis and acquired immunodeficiency syndrome. Am J Med 91: 267–272.
-
11.
Bicanic T, et al. 2009. Relationship of cerebrospinal fluid pressure, fungal burden and outcome in patients with cryptococcal meningitis undergoing serial lumbar punctures. AIDS 23: 701–706.
-
12.
Perfect JR, et al. 2010. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of America. Clin Infect Dis 50: 291–322.
-
13.
Woodworth GF, McGirt MJ, Williams MA, Rigamonti D, 2005. The use of ventriculoperitoneal shunts for uncontrollable intracranial hypertension without ventriculomegally secondary to HIV-associated cryptococcal meningitis. Surg Neurol 63: 529–531.
-
14.
Liliang PC, et al. 2003. Shunt surgery for hydrocephalus complicating cryptococcal meningitis in human immunodeficiency virus negative patients. Clin Infect Dis 37: 673–678.
-
15.
Richardson PM, Mohandas A, Arumugasamy N, 1976. Cerebral cryptococcosis in Malaysia. J Neurol Neurosurg Psychiatry 39: 330–337.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 322 | 279 | 34 |
| Full Text Views | 347 | 19 | 1 |
| PDF Downloads | 128 | 13 | 1 |