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RefWorks
Reference Manager
BibTeX
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-
1.
Peacock SJ, 2006. Melioidosis. Curr Opin Infect Dis 16: 421–428.
-
2.
Chua KL, Chan YY, Gan YH, 2003. Flagella are virulence determinants of Burkholderia pseudomallei. Infect Immun 71: 1622–1629.
-
3.
Tay ST, Cheah PC, Puthucheary SD, 2010. Sequence polymorphism and PCR–restriction fragment length polymorphism analysis of the flagellin gene of Burkholderia pseudomallei. J Clin Microbiol 48: 1464–1467.
-
4.
Cheng AC, Currie BJ, 2005. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev 18: 383–416.
-
5.
Winstanley C, Hales BA, Corkill JE, Gallagher MJ, Hart CA, 1998. Flagellin gene variation between clinical and environmental isolates of Burkholderia pseudomallei contrasts with the invariance among clinical isolates. J Med Microbiol 47: 689–694.
-
6.
Department of Statistics, Malaysia, 2010. Population and Housing Census of Malaysia: Population Distribution and Basic Demographic Characteristics, 2010. Available at: http://www.statistics.gov.my/portal/download_Population/files/census2010/Taburan_Penduduk_dan_Ciri-ciri_Asas_Demografi.pdf. Accessed June 9, 2014.
-
7.
Chrispal A, Rajan SJ, Sathyendra S, 2010. The clinical profile and predictors of mortality in patients with melioidosis in South India. Trop Doct 40: 36–38.
-
8.
Chan KPW, Low JGH, Raghuram J, Fook-Chong SM, Kurup A, 2005. Clinical characteristics and outcome of severe melioidosis requiring intensive care. Chest 128: 3674–3678.
-
9.
Puthucheary SD, Parasakthi N, Lee MK, 1992. Septicaemic melioidosis: a review of 50 cases from Malaysia. Trans R Soc Trop Med Hyg 86: 683–685.
-
10.
How SH, Ng KH, Jamalludin AR, Rathor Y, 2005. Melioidosis in Pahang, Malaysia. Med J Malaysia 60: 606–613.
-
11.
Zanariah H, Chandran LR, Wan Mohamad WB, Wan Nazaimoon WM, Letchuman GR, Jamaiyah H, Fatanah I, Nurain MN, Helen Tee GH, Mohd Rodi I, 2008. Prevalence of diabetes mellitus in Malaysia in 2006 – results of the Third National Health and Morbidity Survey (NHMS III). Diabetes Res Clin Pract 79: S21.
-
12.
Hong CY, Chia KS, Hughes K, Ling SL, 2004. Ethnic differences among Chinese, Malay and Indian patients with type 2 diabetes mellitus in Singapore. Singapore Med J 45: 154–160.
-
13.
Rolim DB, Vilar DCFL, de Góes Cavalcanti LP, Freitas LB, Inglis TJ, Nobre Rodrigues JL, Nagao-Dias AT, 2011. Burkholderia pseudomallei antibodies in individuals living in endemic regions in northeastern Brazil. Am J Trop Med Hyg 84: 302–305.
-
14.
Tan AL, Ang BSP, Ong YY, 1990. Melioidosis: epidemiology and antibiogram of cases in Singapore. Singapore Med J 31: 335–337.
-
15.
Cheng AC, Jacups SP, Anstey NM, Currie BJ, 2003. Proposed scoring system for predicting mortality in melioidosis. Trans R Soc Trop Med Hyg 97: 577–581.
-
16.
Ramsay SC, Ketheesan N, Norton R, Watson AM, LaBrooy J, 2002. Peripheral blood lymphocyte subsets in acute human melioidosis. Eur J Clin Microbiol Infect Dis 21: 566–568.
-
17.
Santanirand P, Harley VS, Dance DA, Drasar BS, Bancroft GJ, 1999. Obligatory role of gamma interferon for host survival in a murine model of infection with Burkholderia pseudomallei. Infect Immun 67: 3593–3600.
-
18.
Simpson AJ, Smith MD, Weverling GJ, Suputtamongkol Y, Angus BJ, Chaowagul W, White NJ, van Deventer SJ, Prins JM, 2000. Prognostic value of cytokine concentrations (tumor necrosis factor-alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis. J Infect Dis 181: 621–625.
-
19.
How SH, Liam CK, 2006. Melioidosis: a potentially life-threatening infection. Med J Malaysia 61: 386–395.
-
20.
Ruangsupanth S, Limwattananon C, Limwattananon S, Chaiyakum A, Sakolchai S, Pongrithsakda V, Susaengrat W, 2004. Appropriate use of antibiotics and patient outcomes in melioidosis. Malay J Pharm Sci 2: 9–20.
-
21.
Vlieghe E, Kruy L, De Smet B, Kham C, Veng CH, Phe T, Koole O, Thai S, Lynen L, Jacobs J, 2011. Melioidosis, Phnom Penh, Cambodia. Emerg Infect Dis 17: 1289–1292.
-
22.
Waiwarawooth J, Jutiworukul K, Joraka W, 2008. Epidemiology and clinical outcome of melioidosis at Chonburi Hospital, Thailand. J Infect Dis Antimicrob Agents 25: 1–11.
-
23.
Haase A, Smith-Vaughan H, Melder A, Wood Y, Janmaat A, Gilfedder J, Kemp D, Currie B, 1995. Subdivision of Burkholderia pseudomallei ribotypes into multiple types by random amplified polymorphic DNA analysis provides new insights into epidemiology. J Clin Microbiol 33: 1687–1690.
-
24.
Cheng AC, Day NPJ, Mayo MJ, Gal D, Currie BJ, 2005. Burkholderia pseudomallei strain type, based on pulsed-field gel electrophoresis, does not determine disease presentation in melioidosis. Microbes Infect 7: 104–109.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 119 | 97 | 10 |
| Full Text Views | 305 | 8 | 1 |
| PDF Downloads | 103 | 9 | 1 |
Predictors of Severe Disease in Melioidosis Patients in Kuala Lumpur, Malaysia
Ardita Dewi Roslani Mohd Roslani
Ardita Dewi Roslani Mohd Roslani
Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
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Sun Tee Tay
Sun Tee Tay
Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
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Savithri D. Puthucheary
Savithri D. Puthucheary
Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
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Devi V. Rukumani
Devi V. Rukumani
Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
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I-Ching Sam
I-Ching Sam
Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
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The predictors of severe disease or death were determined for 85 melioidosis patients in Kuala Lumpur, Malaysia. Most of the patients were male, > 40 years old, and diabetic. Severe disease or death occurred in 28 (32.9%) cases. Lower lymphocyte counts and positive blood cultures were significant independent predictors of severe disease, but age, presentations with pneumonia, inappropriate empirical antibiotics, or flagellin types of the infecting isolates were not. Knowledge of local predictors of severe disease is useful for clinical management.
Author Notes
Financial support: The study was funded by PPP Grant P0042/2009B and High-Impact Research Grant E000013-20001 from University Malaya.
Authors' addresses: Ardita Dewi Roslani Mohd Roslani, Sun Tee Tay, Devi V. Rukumani, and I-Ching Sam, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia, E-mails: ardita@ummc.edu.my, tayst@um.edu.my, rukumani@ummc.edu.my, and jicsam@ummc.edu.my. Savithri D. Puthucheary, Medical Education, Research and Evaluation Department, Duke-National University of Singapore Graduate Medical School, Singapore, E-mail: savithiri.puthucheary@duke-nus.edu.sg.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Peacock SJ, 2006. Melioidosis. Curr Opin Infect Dis 16: 421–428.
-
2.
Chua KL, Chan YY, Gan YH, 2003. Flagella are virulence determinants of Burkholderia pseudomallei. Infect Immun 71: 1622–1629.
-
3.
Tay ST, Cheah PC, Puthucheary SD, 2010. Sequence polymorphism and PCR–restriction fragment length polymorphism analysis of the flagellin gene of Burkholderia pseudomallei. J Clin Microbiol 48: 1464–1467.
-
4.
Cheng AC, Currie BJ, 2005. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev 18: 383–416.
-
5.
Winstanley C, Hales BA, Corkill JE, Gallagher MJ, Hart CA, 1998. Flagellin gene variation between clinical and environmental isolates of Burkholderia pseudomallei contrasts with the invariance among clinical isolates. J Med Microbiol 47: 689–694.
-
6.
Department of Statistics, Malaysia, 2010. Population and Housing Census of Malaysia: Population Distribution and Basic Demographic Characteristics, 2010. Available at: http://www.statistics.gov.my/portal/download_Population/files/census2010/Taburan_Penduduk_dan_Ciri-ciri_Asas_Demografi.pdf. Accessed June 9, 2014.
-
7.
Chrispal A, Rajan SJ, Sathyendra S, 2010. The clinical profile and predictors of mortality in patients with melioidosis in South India. Trop Doct 40: 36–38.
-
8.
Chan KPW, Low JGH, Raghuram J, Fook-Chong SM, Kurup A, 2005. Clinical characteristics and outcome of severe melioidosis requiring intensive care. Chest 128: 3674–3678.
-
9.
Puthucheary SD, Parasakthi N, Lee MK, 1992. Septicaemic melioidosis: a review of 50 cases from Malaysia. Trans R Soc Trop Med Hyg 86: 683–685.
-
10.
How SH, Ng KH, Jamalludin AR, Rathor Y, 2005. Melioidosis in Pahang, Malaysia. Med J Malaysia 60: 606–613.
-
11.
Zanariah H, Chandran LR, Wan Mohamad WB, Wan Nazaimoon WM, Letchuman GR, Jamaiyah H, Fatanah I, Nurain MN, Helen Tee GH, Mohd Rodi I, 2008. Prevalence of diabetes mellitus in Malaysia in 2006 – results of the Third National Health and Morbidity Survey (NHMS III). Diabetes Res Clin Pract 79: S21.
-
12.
Hong CY, Chia KS, Hughes K, Ling SL, 2004. Ethnic differences among Chinese, Malay and Indian patients with type 2 diabetes mellitus in Singapore. Singapore Med J 45: 154–160.
-
13.
Rolim DB, Vilar DCFL, de Góes Cavalcanti LP, Freitas LB, Inglis TJ, Nobre Rodrigues JL, Nagao-Dias AT, 2011. Burkholderia pseudomallei antibodies in individuals living in endemic regions in northeastern Brazil. Am J Trop Med Hyg 84: 302–305.
-
14.
Tan AL, Ang BSP, Ong YY, 1990. Melioidosis: epidemiology and antibiogram of cases in Singapore. Singapore Med J 31: 335–337.
-
15.
Cheng AC, Jacups SP, Anstey NM, Currie BJ, 2003. Proposed scoring system for predicting mortality in melioidosis. Trans R Soc Trop Med Hyg 97: 577–581.
-
16.
Ramsay SC, Ketheesan N, Norton R, Watson AM, LaBrooy J, 2002. Peripheral blood lymphocyte subsets in acute human melioidosis. Eur J Clin Microbiol Infect Dis 21: 566–568.
-
17.
Santanirand P, Harley VS, Dance DA, Drasar BS, Bancroft GJ, 1999. Obligatory role of gamma interferon for host survival in a murine model of infection with Burkholderia pseudomallei. Infect Immun 67: 3593–3600.
-
18.
Simpson AJ, Smith MD, Weverling GJ, Suputtamongkol Y, Angus BJ, Chaowagul W, White NJ, van Deventer SJ, Prins JM, 2000. Prognostic value of cytokine concentrations (tumor necrosis factor-alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis. J Infect Dis 181: 621–625.
-
19.
How SH, Liam CK, 2006. Melioidosis: a potentially life-threatening infection. Med J Malaysia 61: 386–395.
-
20.
Ruangsupanth S, Limwattananon C, Limwattananon S, Chaiyakum A, Sakolchai S, Pongrithsakda V, Susaengrat W, 2004. Appropriate use of antibiotics and patient outcomes in melioidosis. Malay J Pharm Sci 2: 9–20.
-
21.
Vlieghe E, Kruy L, De Smet B, Kham C, Veng CH, Phe T, Koole O, Thai S, Lynen L, Jacobs J, 2011. Melioidosis, Phnom Penh, Cambodia. Emerg Infect Dis 17: 1289–1292.
-
22.
Waiwarawooth J, Jutiworukul K, Joraka W, 2008. Epidemiology and clinical outcome of melioidosis at Chonburi Hospital, Thailand. J Infect Dis Antimicrob Agents 25: 1–11.
-
23.
Haase A, Smith-Vaughan H, Melder A, Wood Y, Janmaat A, Gilfedder J, Kemp D, Currie B, 1995. Subdivision of Burkholderia pseudomallei ribotypes into multiple types by random amplified polymorphic DNA analysis provides new insights into epidemiology. J Clin Microbiol 33: 1687–1690.
-
24.
Cheng AC, Day NPJ, Mayo MJ, Gal D, Currie BJ, 2005. Burkholderia pseudomallei strain type, based on pulsed-field gel electrophoresis, does not determine disease presentation in melioidosis. Microbes Infect 7: 104–109.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 119 | 97 | 10 |
| Full Text Views | 305 | 8 | 1 |
| PDF Downloads | 103 | 9 | 1 |