Prevention of Malaria during Pregnancy: Assessing the Effect of the Distribution of IPTp Through the National Policy in Benin

Agnès Le Port Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France; Faculté de Pharmacie, Université Paris Descartes, Paris, France; Institut des Sciences Biomédicales Appliquées (ISBA), Cotonou, Benin; Faculté des Sciences de la Santé (FSS), Cotonou, Benin

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Gilles Cottrell Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France; Faculté de Pharmacie, Université Paris Descartes, Paris, France; Institut des Sciences Biomédicales Appliquées (ISBA), Cotonou, Benin; Faculté des Sciences de la Santé (FSS), Cotonou, Benin

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Célia Dechavanne Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France; Faculté de Pharmacie, Université Paris Descartes, Paris, France; Institut des Sciences Biomédicales Appliquées (ISBA), Cotonou, Benin; Faculté des Sciences de la Santé (FSS), Cotonou, Benin

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Valérie Briand Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France; Faculté de Pharmacie, Université Paris Descartes, Paris, France; Institut des Sciences Biomédicales Appliquées (ISBA), Cotonou, Benin; Faculté des Sciences de la Santé (FSS), Cotonou, Benin

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Aziz Bouraima Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France; Faculté de Pharmacie, Université Paris Descartes, Paris, France; Institut des Sciences Biomédicales Appliquées (ISBA), Cotonou, Benin; Faculté des Sciences de la Santé (FSS), Cotonou, Benin

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José Guerra Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France; Faculté de Pharmacie, Université Paris Descartes, Paris, France; Institut des Sciences Biomédicales Appliquées (ISBA), Cotonou, Benin; Faculté des Sciences de la Santé (FSS), Cotonou, Benin

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Isabelle Choudat Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France; Faculté de Pharmacie, Université Paris Descartes, Paris, France; Institut des Sciences Biomédicales Appliquées (ISBA), Cotonou, Benin; Faculté des Sciences de la Santé (FSS), Cotonou, Benin

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Achille Massougbodji Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France; Faculté de Pharmacie, Université Paris Descartes, Paris, France; Institut des Sciences Biomédicales Appliquées (ISBA), Cotonou, Benin; Faculté des Sciences de la Santé (FSS), Cotonou, Benin

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Benjamin Fayomi Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France; Faculté de Pharmacie, Université Paris Descartes, Paris, France; Institut des Sciences Biomédicales Appliquées (ISBA), Cotonou, Benin; Faculté des Sciences de la Santé (FSS), Cotonou, Benin

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Florence Migot-Nabias Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France; Faculté de Pharmacie, Université Paris Descartes, Paris, France; Institut des Sciences Biomédicales Appliquées (ISBA), Cotonou, Benin; Faculté des Sciences de la Santé (FSS), Cotonou, Benin

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André Garcia Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France; Faculté de Pharmacie, Université Paris Descartes, Paris, France; Institut des Sciences Biomédicales Appliquées (ISBA), Cotonou, Benin; Faculté des Sciences de la Santé (FSS), Cotonou, Benin

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Michel Cot Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France; Faculté de Pharmacie, Université Paris Descartes, Paris, France; Institut des Sciences Biomédicales Appliquées (ISBA), Cotonou, Benin; Faculté des Sciences de la Santé (FSS), Cotonou, Benin

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DOI:
https://doi.org/10.4269/ajtmh.2011.10-0319
Volume/Issue:
Volume 84: Issue 2
Page(s):
270–275
Restricted access
Get Permissions

The efficiency of malaria prevention during pregnancy was compared between three studies in Benin for malaria infection of the placenta (MIP) and low birth weight (LBW). The first was carried out when chloroquine prophylaxis was still recommended, the second was an intermittent preventive treatment in pregnancy (IPTp) clinical trial comparing sulfadoxine pyrimetamine (SP) versus mefloquine, and the third was an observational study after SP-IPTp national implementation. We showed an association between the use of IPTp and the reduction of LBW (10% with national IPTp and 8.7% in IPTp trial versus 15.7% in pre-trial study). The effect on MIP was better in the trial (2.9% versus 11.2% and 16.7% for national IPTp and pre-trial studies, respectively). In spite of a good overall compliance with the national IPTp (with 84% of women taking at least one dose of SP), there are still failures in adherence to the directly observed therapy (DOT) scheme and needs for better training of health staff.

Author Notes

*Address correspondence to Agnès Le Port, IRD/UMR 216, Mère et Enfant Face aux Infections Tropicales, Faculté des Sciences Pharmaceutiques, Université Paris Descartes, 4 avenue de l'Observatoire, 75270 Paris Cedex 06, France. E-mail: agnesleport@yahoo.fr

Financial support: The following institutions provided support: Agence Nationale de la Recherche (ANR), Institut de Recherche pour le Développement (IRD), Ministère de la Recherche et des Technologies, France, Fondation de France, and Fondation Mérieux.

Authors' addresses: Agnès Le Port, Célia Dechavanne, Valérie Briand, José Guerra, Isabelle Choudat, Florence Migot-Nabias, André Garcia, and Michel Cot, IRD/UMR 216, Mère et Enfant Face aux Infections Tropicales, Faculté des Sciences Pharmaceutiques, Université Paris, Paris, France, E-mails: Agnes.Leport@ird.fr, celia_dv@yahoo.fr, valerie.briand@gmail.com, jose8293@hotmail.com, isa.chou@gmail.com, Florence.Migot-Nabias@ird.fr, Andre.Garcia@ird.fr, and Michel.Cot@ird.fr. Gilles Cottrell, IRD, UMR216, Mère et Enfant Face aux Infections Tropicales, Cotonou, Benin, E-mail: Gilles.Cottrell@ird.fr. Aziz Bouraima and Benjamin Fayomi, Institut des Sciences Biolomédicales Appliquées (ISBA), Université d'Abomey Calavi Champ de Foire, Cotonou, E-mails: azlesage@yahoo.fr and bfayomi2@yahoo.fr. Achille Massougbodji, Faculté des Sciences de la Santé (FSS), UER de Parasitologie, Université de Cotonou, Cotonou, Bénin, E-mail: massougbodjiachille@yahoo.fr.

Copyright:
©The American Society of Tropical Medicine and Hygiene 2011
Received:
03 Jun 2010
|
Accepted:
10 Sep 2010
|
Published Online:
04 Feb 2011
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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