Drug-Free Holidays: Pre-Travel versus During Travel Malaria Chemoprophylaxis

G. Dennis Shanks Army Malaria Institute, Brisbane, Queensland, Australia; Walter Reed Army Institute of Research, Silver Spring, Maryland; University of Alabama at Birmingham, Birmingham, Alabama; The Toronto Hospital, Toronto, Ontario, Canada; London School of Hygiene and Tropical Medicine, London, United Kingdom; World Health Organization Collaborating Centre for Travelers’ Health, University of Zurich, Zurich, Switzerland

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Alan J. Magill Army Malaria Institute, Brisbane, Queensland, Australia; Walter Reed Army Institute of Research, Silver Spring, Maryland; University of Alabama at Birmingham, Birmingham, Alabama; The Toronto Hospital, Toronto, Ontario, Canada; London School of Hygiene and Tropical Medicine, London, United Kingdom; World Health Organization Collaborating Centre for Travelers’ Health, University of Zurich, Zurich, Switzerland

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David O. Freedman Army Malaria Institute, Brisbane, Queensland, Australia; Walter Reed Army Institute of Research, Silver Spring, Maryland; University of Alabama at Birmingham, Birmingham, Alabama; The Toronto Hospital, Toronto, Ontario, Canada; London School of Hygiene and Tropical Medicine, London, United Kingdom; World Health Organization Collaborating Centre for Travelers’ Health, University of Zurich, Zurich, Switzerland

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Jay S. Keystone Army Malaria Institute, Brisbane, Queensland, Australia; Walter Reed Army Institute of Research, Silver Spring, Maryland; University of Alabama at Birmingham, Birmingham, Alabama; The Toronto Hospital, Toronto, Ontario, Canada; London School of Hygiene and Tropical Medicine, London, United Kingdom; World Health Organization Collaborating Centre for Travelers’ Health, University of Zurich, Zurich, Switzerland

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David J. Bradley Army Malaria Institute, Brisbane, Queensland, Australia; Walter Reed Army Institute of Research, Silver Spring, Maryland; University of Alabama at Birmingham, Birmingham, Alabama; The Toronto Hospital, Toronto, Ontario, Canada; London School of Hygiene and Tropical Medicine, London, United Kingdom; World Health Organization Collaborating Centre for Travelers’ Health, University of Zurich, Zurich, Switzerland

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Robert Steffen Army Malaria Institute, Brisbane, Queensland, Australia; Walter Reed Army Institute of Research, Silver Spring, Maryland; University of Alabama at Birmingham, Birmingham, Alabama; The Toronto Hospital, Toronto, Ontario, Canada; London School of Hygiene and Tropical Medicine, London, United Kingdom; World Health Organization Collaborating Centre for Travelers’ Health, University of Zurich, Zurich, Switzerland

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Although efficacious forms of malaria chemoprophylaxis currently exist, many travelers to malaria-endemic areas fail to use them effectively. We suggest that taking antimalarial medications prior to travel may prevent more malaria by improving compliance. Treatment regimens of antimalarial drugs taken prior to travel could protect persons for up to one month of exposure. We urge additional testing of pre-travel malaria chemoprophylaxis regimens.

Author Notes

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    Davis TM, Hung TY, Sim IK, Karunajeewa HA, Ilett KF, 2005. Piperaquine: a resurgent antimalarial drug. Drugs 65 :75–87.

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