SEROPREVALENCE OF CHIKUNGUNYA VIRUS INFECTION ON GRANDE COMORE ISLAND, UNION OF THE COMOROS, 2005

KIBET SERGON Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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ALI AHMED YAHAYA Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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JENNIFER BROWN Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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SAID A. BEDJA Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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MOHAMMED MLINDASSE Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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NAPHTALI AGATA Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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YOKOUIDE ALLARANGER Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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MAMADOU D. BALL Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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ANN M. POWERS Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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VICTOR OFULA Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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CLAYTON ONYANGO Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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LIMBASO S. KONONGOI Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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ROSEMARY SANG Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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M. KARIUKI NJENGA Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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ROBERT F. BREIMAN Epidemiology and Laboratory Training Program, Nairobi, Kenya; Ministry of Health, Moroni, Comoros; Centers for Disease Control and Prevention, Fort Collins, Colorado; World Health Organization, African Regional Office, Brazzaville, Republic of Congo; World Health Organization, Moroni, Comoros; Kenya Medical Research Institute, Nairobi, Kenya; International Emerging Infections Program–Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya

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An outbreak of Chikungunya virus (CHIKV) illness associated with high fever combined with prolonged and severe arthralgias occurred on Grande Comore Island from January through May 2005; 5,202 cases were reported. A seroprevalence study was conducted to define the extent of transmission on the island. We conducted a cross-sectional survey using a multistage sampling technique. A total of 481 households were sampled. In each household, one resident was selected randomly for interview and blood collection. We administered questionnaires and tested 331 sera for CHIKV-specific IgM and IgG antibodies by capture enzyme-linked immunosorbent assay. Infection with CHIKV infection (seropositivity) was defined as presence of IgG and/or IgM antibodies to CHIKV. A total of 331 (69%) of 481 survey participants consented to blood collection. Antibodies to CHIKV were detected in 63% of sera; IgM antibodies were found in 60% of specimens and IgG antibodies were detected in 27% of specimens. Extrapolation of the findings to the entire Grande Comore population suggested that nearly 215,000 people were infected with CHIKV during the outbreak. A total of 79% of the seropositive persons were hospitalized or stayed at home in bed for a mean of 6 days (range = 1–30 days); 52% missed work or school for a mean of 7 days (range = 1–40 days). The findings suggest that CHIKV was broadly transmitted during the outbreak with a high attack rate. Although not fatal during this outbreak, CHIKV infection caused significant morbidity and decreased economic productivity.

Author Notes

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