A CASE-CONTROL AUDITORY EVALUATION OF PATIENTS TREATED WITH ARTEMETHER-LUMEFANTRINE

Stephen Toovey Royal Free and University College Medical School, London, United Kingdom

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Author Notes

  • 1

    Kager PA, Schultz MJ, Zijlstra EE, van den Berg B, van Boxtel C, 1994. Arteether administration in humans: preliminary studies of pharmacokinetics, safety and tolerance. Trans R Soc Trop Med Hyg 88 :53–54.

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  • 2

    Toovey S, Jamieson A, 2004. Audiometric changes associated with the treatment of uncomplicated falciparum malaria with co-artemether. Trans R Soc Trop Med Hyg 98 :261–267.

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  • 3

    Toovey S, 2006. Effects of weight, age, and time on artemether-lumefantrine associated ototoxicity and evidence of irreversibility. Travel Med Infect Dis 4 :71–76.

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  • 4

    Claessen FA, van Boxtel CJ, Perenboom RM, Tange RA, Wetsteijn JC, Kager PA, 1998. Quinine pharmacokinetics: ototoxic and cardiotoxic effects in healthy Caucasian subjects and in patients with falciparum malaria. Trop Med Int Health 3 :482–489.

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  • 5

    Tange RA, Dreschler WA, Claessen FA, Perenboom RM, 1997. Ototoxic reactions of quinine in healthy persons and patients with Plasmodium falciparum infection. Auris Nasus Larynx 24 :131–136.

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  • 6

    Hutagalung R, Htoo H, Nwee P, Arunkamomkiri J, Zwang J, Carrara VI, Ashley E, Singhasivanon P, White NJ, Nosten F, 2006. A case-control auditory evaluation of patients treated with artemether-lumefantrine. Am J Trop Med Hyg 74 :211–214.

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  • 7

    Kissinger E, Hien TT, Hung NT, Nam ND, Tuyen NL, Dinh BV, Mann C, Phu NH, Loc PP, Simpson JA, White NJ, Farrar JJ, 2000. Clinical and neurophysiological study of the effects of multiple doses of artemisinin on brain-stem function in Vietnamese patients. Am J Trop Med Hyg 63 :48–55.

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  • 8

    van Vugt M, Angus BJ, Price RN, Mann C, Simpson JA, Poletto C, Htoo SE, Looareesuwan S, White NJ, Nosten F, 2000. A case-control auditory evaluation of patients treated with artemisinin derivatives for multidrug-resistant Plasmodium falciparum malaria. Am J Trop Med Hyg 62 :65–69.

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  • 9

    Toovey S, 2005. Reply to comment on: audiometric changes associated with the treatment of uncomplicated falciparum malaria with co-artemether. Trans R Soc Trop Med Hyg 99 :314–315.

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  • 10

    Toovey S, 2005. Reply to comment on: Audiometric changes associated with the treatment of uncomplicated falciparum malaria with co-artemether. Trans R Soc Trop Med Hyg 99 :316–317.

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  • 11

    Hien TT, Turner GD, Mai NT, Phu NH, Bethell D, Blakemore WF, Cavanagh JB, Dayan A, Medana I, Weller RO, Day NP, White NJ, 2003. Neuropathological assessment of artemether-treated severe malaria. Lancet 362 :295–296.

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  • 12

    Schmuck G, Roehrdanz E, Haynes RK, Kahl R, 2002. Neurotoxic mode of action of artemisinin. Antimicrob Agents Chemother 46 :821–827.

  • 13

    White NJ, Dondorp AM, Nosten F, Day NPJ, 2006. Artesunate versus quinine for severe falciparum malaria—authors’ reply. Lancet 367 :111–112.

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  • 14

    Franco-Paredes C, Dismukes R, Nicolls D, Kozarsky PE, 2005. Reply to Newton et al. Clin Infect Dis 41 :1688–1689.

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