| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 291 | 137 | 19 |
| Full Text Views | 327 | 0 | 0 |
| PDF Downloads | 81 | 0 | 0 |
Increased serum levels of interferon-gamma and interleukin-12 during human brucellosis.
K Ahmed
K Ahmed
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Japan.
Search for other papers by K Ahmed in
Current site
Google Scholar
PubMed
Search for other papers by K Ahmed in
Current site
Google Scholar
PubMed
K A Al-Matrouk
K A Al-Matrouk
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Japan.
Search for other papers by K A Al-Matrouk in
Current site
Google Scholar
PubMed
Search for other papers by K A Al-Matrouk in
Current site
Google Scholar
PubMed
G Martinez
G Martinez
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Japan.
Search for other papers by G Martinez in
Current site
Google Scholar
PubMed
Search for other papers by G Martinez in
Current site
Google Scholar
PubMed
K Oishi
K Oishi
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Japan.
Search for other papers by K Oishi in
Current site
Google Scholar
PubMed
Search for other papers by K Oishi in
Current site
Google Scholar
PubMed
V O Rotimi
V O Rotimi
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Japan.
Search for other papers by V O Rotimi in
Current site
Google Scholar
PubMed
Search for other papers by V O Rotimi in
Current site
Google Scholar
PubMed
T Nagatake
T Nagatake
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Japan.
Search for other papers by T Nagatake in
Current site
Google Scholar
PubMed
Search for other papers by T Nagatake in
Current site
Google Scholar
PubMed
Brucellosis is a zoonotic disease that often becomes chronic with a high rate of recurrence. To understand the cytokines induced during this infection we determined the levels of interleukin (IL)-1beta, IL-2, IL-4, IL-8, IL-12, tumor necrosis factor-of (TNF-alpha) and interferon-gamma (IFN-gamma) in serum of patients with brucellosis and compared with those without brucellosis and controls. Control sera were taken from healthy persons residing in an area that was not endemic for brucellosis. The levels of IL-1, IL-2, IL-4, and TNF-alpha were not detectable in all the sera from patients. There was no difference in the level of IL-8 in patients with brucellosis and those without this disease. However, IL-8 was significantly higher in these two groups of patients compared with the controls. Significantly higher levels of IL-12 and IFN-alpha were found in the serum of patients with brucellosis compared with patients without brucellosis and controls. These data indicate that there is induction of Thl type cytokines during human brucellosis.
Author Notes
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 291 | 137 | 19 |
| Full Text Views | 327 | 0 | 0 |
| PDF Downloads | 81 | 0 | 0 |