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The Effects of Hemoglobin Genotype and Abo Blood Group on the Formation of Rosettes by Plasmodium falciparum-Infected Red Blood Cells
Rachanee Udomsangpetch
Rachanee Udomsangpetch
Department of Pathobiology, Faculty of Science, Mahidol University, Medical Research Council Laboratories, Department of Immunology, University of Stockholm, Bangkok, Thailand
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James Todd
James Todd
Department of Pathobiology, Faculty of Science, Mahidol University, Medical Research Council Laboratories, Department of Immunology, University of Stockholm, Bangkok, Thailand
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Johan Carlson
Johan Carlson
Department of Pathobiology, Faculty of Science, Mahidol University, Medical Research Council Laboratories, Department of Immunology, University of Stockholm, Bangkok, Thailand
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Brian M. Greenwood
Brian M. Greenwood
Department of Pathobiology, Faculty of Science, Mahidol University, Medical Research Council Laboratories, Department of Immunology, University of Stockholm, Bangkok, Thailand
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The mechanisms by which the hemoglobin genotype AS protect against severe malaria are not fully understood. We have investigated the possibility that protection might be achieved through an inability of red blood cells (RBC) with the AS genotype to form rosettes with RBC infected by Plasmodium falciparum. No evidence was obtained to support this hypothesis because RBC with the AS genotype formed rosettes with wild isolates of P. falciparum as readily as RBC with the AA genotype. However, the previous finding that parasitized RBC form rosettes more readily with RBC belonging to group A or B than with RBC belonging to group O was confirmed even in fresh clinical isolates.
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| Past two years | Past Year | Past 30 Days | |
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