Lymphadenopathy Associated with Leishmania braziliensis Cutaneous Infection

Aldina Barral Servico de Imunologia (HUPES-FAMED), Universidade Federal da Bahia, Fundacao Oswaldo Cruz, Salvador-Bahia, Brazil

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Manoel Barral-Netto Servico de Imunologia (HUPES-FAMED), Universidade Federal da Bahia, Fundacao Oswaldo Cruz, Salvador-Bahia, Brazil

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Roque Almeida Servico de Imunologia (HUPES-FAMED), Universidade Federal da Bahia, Fundacao Oswaldo Cruz, Salvador-Bahia, Brazil

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Amelia Ribeiro De Jesus Servico de Imunologia (HUPES-FAMED), Universidade Federal da Bahia, Fundacao Oswaldo Cruz, Salvador-Bahia, Brazil

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Gabriel Grimaldi Jr Servico de Imunologia (HUPES-FAMED), Universidade Federal da Bahia, Fundacao Oswaldo Cruz, Salvador-Bahia, Brazil

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Eduardo M. Netto Servico de Imunologia (HUPES-FAMED), Universidade Federal da Bahia, Fundacao Oswaldo Cruz, Salvador-Bahia, Brazil

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Ilma Santos Servico de Imunologia (HUPES-FAMED), Universidade Federal da Bahia, Fundacao Oswaldo Cruz, Salvador-Bahia, Brazil

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Olivia Bacellar Servico de Imunologia (HUPES-FAMED), Universidade Federal da Bahia, Fundacao Oswaldo Cruz, Salvador-Bahia, Brazil

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Edgar M. Carvalho Servico de Imunologia (HUPES-FAMED), Universidade Federal da Bahia, Fundacao Oswaldo Cruz, Salvador-Bahia, Brazil

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DOI:
https://doi.org/10.4269/ajtmh.1992.47.587
Volume/Issue:
Volume 47: Issue 5
Page(s):
587–592
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Lymph node involvement by Leishmania during human cutaneous leishmaniasis was reported more than 90 years ago, but the importance of certain Leishmania strains in such dissemination remains largely speculative. We have examined 36 consecutively untreated cutaneous leishmaniasis patients early in their disease; 66.7% had enlarged lymph nodes. Patients with enlarged lymph nodes had higher anti-Leishmania immune responses than patients without such involvement, both at the IgG antibody level (mean ± SD optical density at 492 nm = 0.163 ± 0.089 versus 0.098 ± 0.086; P = 0.009) and in skin test responses (12.4 ± 1O.2 mm versus 5.7 ± 7.3; P = 0.03). Thirteen (62%) of 21 lymph node cultures and 16 (53%) of 30 cultures from cutaneous sites were positive for Leishmania. Eleven of 13 isolates from lymph nodes were characterized by a panel of monoclonal antibodies, and all were typed as L. braziliensis. Our findings stress the importance of L. braziliensis as an agent involved in the early invasion of the lymphatic system.

Author Notes

Copyright:
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene 1992
Published Online:
Nov 1992
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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