Seroepidemiologic Studies of Humoral Immune Response to the Plasmodium falciparum Antigens in Thailand

Pirom Kamol-Ratanakul World Health Organization Collaborating Centre on the Biological Characterization of Malaria Parasites, Chulalongkorn University, Department of Immunology, Stockholm University, Bangkok, Thailand

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Nanthinee Chirakalwasarn World Health Organization Collaborating Centre on the Biological Characterization of Malaria Parasites, Chulalongkorn University, Department of Immunology, Stockholm University, Bangkok, Thailand

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Somrat Lertmaharit World Health Organization Collaborating Centre on the Biological Characterization of Malaria Parasites, Chulalongkorn University, Department of Immunology, Stockholm University, Bangkok, Thailand

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Bodi Dhanamun World Health Organization Collaborating Centre on the Biological Characterization of Malaria Parasites, Chulalongkorn University, Department of Immunology, Stockholm University, Bangkok, Thailand

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Tada Seublinwong World Health Organization Collaborating Centre on the Biological Characterization of Malaria Parasites, Chulalongkorn University, Department of Immunology, Stockholm University, Bangkok, Thailand

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Rachanee Udomsangpetch World Health Organization Collaborating Centre on the Biological Characterization of Malaria Parasites, Chulalongkorn University, Department of Immunology, Stockholm University, Bangkok, Thailand

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Hedvig Perlmann World Health Organization Collaborating Centre on the Biological Characterization of Malaria Parasites, Chulalongkorn University, Department of Immunology, Stockholm University, Bangkok, Thailand

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Peter Perlmann World Health Organization Collaborating Centre on the Biological Characterization of Malaria Parasites, Chulalongkorn University, Department of Immunology, Stockholm University, Bangkok, Thailand

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Sodsri Thaithong World Health Organization Collaborating Centre on the Biological Characterization of Malaria Parasites, Chulalongkorn University, Department of Immunology, Stockholm University, Bangkok, Thailand

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DOI:
https://doi.org/10.4269/ajtmh.1992.47.554
Volume/Issue:
Volume 47: Issue 5
Page(s):
554–561
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We have investigated seroreactivity against Plasmodium falciparum crude parasite antigens, the P. falciparum ring-infected erythrocyte surface antigen (Pf155/RESA), as well as against two synthetic peptides (EENV)6 and (EENVEHDA)3 that represent important epitopes of Pf155/RESA. The study population consisted of 421 children and adult Thais living in an area with moderate malaria transmission. We related these serologic findings to some important epidemiologic baseline data collected in the study area. The parasite rate in study subjects was 18.76%. Sixty-two percent were seropositive to crude P. falciparum antigens, 30.3% to the Pf155/RESA antigen, 23.05% to (EENV)6, and 20.17% to (EENVEHDA)3. Antibody responses to crude P. falciparum antigens and to Pf155/RESA were age dependent and increased with exposure. There was evidence that Pf155/RESA antibodies might play a role in protective immunity in this population. Since Pf155/RESA is a potential vaccine candidate antigen, the information obtained from these field studies will provide some seroepidemiologic baseline data for subsequent vaccine trials.

Author Notes

Copyright:
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene 1992
Published Online:
Nov 1992
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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