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Gametocytocidal Activity of the Antimalarial α/β Arteether against Plasmodium cynomolgi B
Renu Tripathi
Renu Tripathi
Central Drug Research Institute, Central Institute of Medicinal and Aromatic Plants, Lucknow, India
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G. P. Dutta
G. P. Dutta
Central Drug Research Institute, Central Institute of Medicinal and Aromatic Plants, Lucknow, India
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R. A. Vishwakarma
R. A. Vishwakarma
Central Drug Research Institute, Central Institute of Medicinal and Aromatic Plants, Lucknow, India
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A new sesquiterpene lactone α/β arteether (a 30:70 mixture of enantiomers), which possesses very high blood schizontocidal activity, has been evaluated for gametocytocidal/sporontocidal action against Plasmodium cynomolgi B infection in the rhesus monkey. This paper reports gametocytocidal action of this new antimalarial drug at 2.5–5 mg/kg (single im dose) against P. cynomolgi B as shown by the complete absence of mosquito infectivity. No sporontocidal action was demonstrable in the vector at a dose of up to 20–50 mg/kg im.
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| Past two years | Past Year | Past 30 Days | |
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